scholarly journals Houttuynia cordata Thunb extract modulates G0/G1 arrest and Fas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells

2013 ◽  
Vol 20 (1) ◽  
pp. 18 ◽  
Author(s):  
Yuh-Fung Chen ◽  
Jai-Sing Yang ◽  
Wen-Shin Chang ◽  
Shih-Chang Tsai ◽  
Shu-Fen Peng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Human Lung ◽  
Apoptotic Cell ◽  
Death Receptor ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
G1 Arrest ◽  
Houttuynia Cordata ◽  
Houttuynia Cordata Thunb

Extract from the Leaves of Toona sinensis Roemor Exerts Potent Antiproliferative Effect on Human Lung Cancer Cells

2002 ◽  
Vol 30 (02n03) ◽  
pp. 307-314 ◽  
Author(s):  
Hui-Chiu Chang ◽  
Wen-Chun Hung ◽  
Ming-Shyan Huang ◽  
Hseng-Kuang Hsu
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Apoptotic Cell ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Lung Fibroblasts ◽  
Human Lung Cancer ◽  
Toona Sinensis

Recent study indicated that the components of Toona sinensis Roemor have potent anti-inflammatory and analgesic effects. These components have also been reported to inhibit the growth of boils in vivo. In this study, we investigated the effect of crude extract from the leaves of Toona sinensis Roemor on the proliferation of A549 lung cancer cells. We found that the extract effectively blocked cell cycle progression by inhibiting the expression of cyclin D1 and E in A549 cells. Additionally, incubation of the extract led to activation of caspase-3-like proteases and apoptotic cell death. Conversely, the extract did not show any significant cytotoxic effect on primarily cultured human foreskin fibroblasts or MRC-5 human lung fibroblasts. Therefore, antiproliferative action of the extract is specific for tumor cells. Our results suggest that the components of Toona sinensis Roemor have potent anticancer effects in vitro and identification of the useful components in the extract may lead to the development of a novel class of anticancer drugs.

Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells

2011 ◽  
Vol 55 (2) ◽  
pp. 300-309 ◽  
Author(s):  
Cheng-Yun Jin ◽  
Cheol Park ◽  
Hye Jin Hwang ◽  
Gi-Young Kim ◽  
Byung Tae Choi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Human Lung ◽  
Death Receptor ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Death Receptor 5 ◽  
Induced Apoptosis

scholarly journals Ursolic Acid Induces Apoptotic Cell Death Through AIF and Endo G Release Through a Mitochondria-dependent Pathway in NCI-H292 Human Lung Cancer Cells In Vitro

In Vivo ◽  
2019 ◽  
Vol 33 (2) ◽  
pp. 383-391 ◽  
Author(s):  
CHIUNG-JU CHEN ◽  
YUNG-LUEN SHIH ◽  
MING-YANG YEH ◽  
NIEN-CHIEH LIAO ◽  
HSUEH-YU CHUNG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Human Lung ◽  
Apoptotic Cell ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Dependent Pathway
Sign in / Sign up

Export Citation Format

Share Document