scholarly journals Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

2014 ◽  
Vol 15 (1) ◽  
pp. 74 ◽  
Author(s):  
William Spears ◽  
Matthew Furgerson ◽  
John Sweetnam ◽  
Parker Evans ◽  
Marla Gearing ◽  
...  
Keyword(s):  
Cell Death ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Hirano Bodies ◽  
Intracellular Domain

scholarly journals The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Daniel A. Bórquez ◽  
Christian González-Billault
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Molecular Mechanisms ◽  
Precursor Protein ◽  
Amyloid Peptide ◽  
Intracellular Domain ◽  
Multiprotein Complexes ◽  
Amyloid Cascade

Since its proposal in 1994, the amyloid cascade hypothesis has prevailed as the mainstream research subject on the molecular mechanisms leading to the Alzheimer's disease (AD). Most of the field had been historically based on the role of the different forms of aggregation ofβ-amyloid peptide (Aβ). However, a soluble intracellular fragment termed amyloid precursor protein (APP) intracellular domain (AICD) is produced in conjunction with Aβfragments. This peptide had been shown to be highly toxic in both culture neurons and transgenic mice models. With the advent of this new toxic fragment, the centerpiece for the ethiology of the disease may be changed. This paper discusses the potential role of multiprotein complexes between the AICD and its adapter protein Fe65 and how this could be a potentially important new agent in the neurodegeneration observed in the AD.

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

2003 ◽  
Vol 84 (4) ◽  
pp. 864-877 ◽  
Author(s):  
Yuichi Hashimoto ◽  
Osahiko Tsuji ◽  
Takako Niikura ◽  
Yohichi Yamagishi ◽  
Miho Ishizaka ◽  
...  
Keyword(s):  
Cell Death ◽  
Amyloid Precursor Protein ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Precursor Protein

scholarly journals The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

2010 ◽  
Vol 285 (53) ◽  
pp. 41443-41454 ◽  
Author(s):  
Nikolai D. Belyaev ◽  
Katherine A. B. Kellett ◽  
Caroline Beckett ◽  
Natalia Z. Makova ◽  
Timothy J. Revett ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Intracellular Domain ◽  
Dependent Pathway

scholarly journals Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content

2007 ◽  
Vol 102 (4) ◽  
pp. 1264-1275 ◽  
Author(s):  
Runa Hamid ◽  
Ellen Kilger ◽  
Michael Willem ◽  
Neville Vassallo ◽  
Markus Kostka ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Calcium Homeostasis ◽  
Precursor Protein ◽  
Atp Content ◽  
Intracellular Domain ◽  
Cellular Calcium

scholarly journals Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31754 ◽  
Author(s):  
Victoria Lewis ◽  
Isobel J. Whitehouse ◽  
Herbert Baybutt ◽  
Jean C. Manson ◽  
Steven J. Collins ◽  
...  
Keyword(s):  
Protein Expression ◽  
Amyloid Precursor Protein ◽  
Prion Protein ◽  
Cellular Prion Protein ◽  
Precursor Protein ◽  
Intracellular Domain

scholarly journals Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)

2002 ◽  
Vol 277 (16) ◽  
pp. 13389-13393 ◽  
Author(s):  
Dieter Edbauer ◽  
Michael Willem ◽  
Sven Lammich ◽  
Harald Steiner ◽  
Christian Haass
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Insulin Degrading Enzyme ◽  
Intracellular Domain ◽  
Degrading Enzyme ◽  
Β Amyloid

scholarly journals P2-032: Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

2006 ◽  
Vol 2 ◽  
pp. S241-S241
Author(s):  
Rupert Egensperger ◽  
Thorsten Mueller ◽  
Caoimhin G. Concannon ◽  
Manus W. Ward ◽  
Donat Kogel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Intracellular Domain ◽  
Cytoskeletal Dynamics ◽  
Modulation Of Gene Expression
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