Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma

Hepatitis C virus (HCV) infection is a worldwide health problem and is one of the main causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Despite recent improvements, effective treatments for HCC are still missing and new tools for early detection are needed. Non-coding RNAs (ncRNAs) have emerged as important regulators of gene expression and key players in human carcinogenesis, including HCC. Aberrant expression of ncRNAs is associated with HCC metastasis, invasion, dissemination, and recurrence. This review will focus on the recent advances in ncRNA expression profiles, their dysregulation in HCV-related HCC, and the clinical perspective of ncRNA signatures for the early detection of HCC.

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Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma

FEBS Letters ◽

10.1016/s0014-5793(03)01345-0 ◽

2003 ◽

Vol 555 (3) ◽

pp. 583-590 ◽

Cited By ~ 26

Author(s):

Toshimasa Okada ◽

Norio Iizuka ◽

Hisafumi Yamada-Okabe ◽

Naohide Mori ◽

Takao Tamesa ◽

...

Keyword(s):

Gene Expression ◽

Hepatocellular Carcinoma ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Gene Expression Profile ◽

Expression Profile ◽

P53 Status

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Obesity and recurrence-free survival in patients with hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C

Annals of Gastroenterological Surgery ◽

10.1002/ags3.12183 ◽

2018 ◽

Vol 2 (4) ◽

pp. 319-326 ◽

Cited By ~ 4

Author(s):

Hiroji Shinkawa ◽

Shogo Tanaka ◽

Shigekazu Takemura ◽

Tokuji Ito ◽

Takanori Aota ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Sustained Virological Response ◽

Chronic Hepatitis C ◽

Virological Response ◽

Interferon Therapy ◽

Recurrence Free Survival ◽

Free Survival

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Optimum initiation-time of direct-acting antivirals for hepatitis C after curative ablation of hepatocellular carcinoma improves neoplastic recurrence-free survival

International Journal of Cancer and Biomedical Research ◽

10.21608/jcbr.2021.64062.1182 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Ahmed Elhadidy ◽

Ahmed Selim ◽

Mohamed Sarhan ◽

Mohamed Mabrouk ◽

Heba Samier ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Hepatitis C ◽

Recurrence Free Survival ◽

Initiation Time ◽

Direct Acting Antivirals ◽

Free Survival ◽

Direct Acting

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Association between Cluster of Differentiation 24 (CD24) Polymorphism, Talin-1 gene expression and Hepatocellular Carcinoma prevalence in Egyptian population

Archives of Medical Science ◽

10.5114/aoms/140451 ◽

2021 ◽

Author(s):

Mohamed Hafez ◽

Lina Jamil ◽

Lubna Jamil ◽

Sherine Ibrahim

Keyword(s):

Gene Expression ◽

Hepatocellular Carcinoma ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Genetic Polymorphism ◽

Fragment Length Polymorphism ◽

Significant Determinant ◽

Pcr Rflp ◽

Cluster Of Differentiation ◽

Restriction Fragment Length

IntroductionBackground: Hepatitis C is considered as one of the most popular diseases in Egypt. Our aim is to clarify the association between Cluster of Differentiation 24 (CD24) polymorphism, Talin-1 gene expression and the prevalence of hepatocellular carcinoma in Egyptian Hepatitis C virus patients.Material and methodsThe link between CD24 polymorphism rs8734 and the prevalence of hepatocellular carcinoma was assessed between 200 control subjects and 400 hepatitis C virus patients (HCV), patients were classified as follows; 200 patients with HCV and 200 with HCV and hepatocellular carcinoma (HCC) by histopathological assessment and PCR-restriction fragment length polymorphism (PCR-RFLP).ResultsResults: The hepatitis c patients with HCC showed significant increase in alpha fetoprotein (AFP) and Talin-1 gene expression compared to patients with HCV as well as in healthy volunteers. Furthermore, the frequencies of CD 24 170 CT/TT genotype were significantly higher in HCV patients without complications (60%) when compared to CC genotype (40%) (OR= 6 at X2= 14.41, P = 0.0007), and in HCV with HCC patients (90%) when compared to CC genotype (10%) (OR= 36 at X2= 14.41, P = 0.0007).ConclusionsThese data suggests that CD24 genetic polymorphism rs8734 and Talin-1 gene expression may be a significant determinant for the prevalence of hepatocellular carcinoma in HCV patients.

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