Cardio-metabolic profile is a determinant of carotid artery disease quantified by Magnetic Resonance Imaging

Background Comprehensive hemodynamic impairment mapping using blood oxygenation‐level dependent (BOLD) cerebrovascular reactivity (CVR) can be used to identify hemodynamically relevant symptomatic unilateral carotid artery disease. Methods and Results This prospective cohort study was conducted between February 2015 and July 2020 at the Clinical Neuroscience Center of the University Hospital Zurich, Zurich, Switzerland. One hundred two patients with newly diagnosed symptomatic unilateral internal carotid artery (ICA) occlusion or with 70% to 99% ICA stenosis were included. An age‐matched healthy cohort of 12 subjects underwent an identical BOLD functional magnetic resonance imaging examination. Using BOLD functional magnetic resonance imaging with a standardized CO 2 stimulus, CVR impairment was evaluated. Moreover, embolic versus hemodynamic ischemic patterns were evaluated on diffusion‐weighted imaging. Sixty‐seven patients had unilateral ICA occlusion and 35 patients unilateral 70% to 99% ICA stenosis. Patients with ICA occlusion exhibited lower whole‐brain and ipsilateral hemisphere mean BOLD‐CVR values as compared with healthy subjects (0.12±0.08 versus 0.19±0.04, P =0.004 and 0.09±0.09 versus 0.18±0.04, P <0.001) and ICA stenosis cohort (0.12±0.08 versus 0.16±0.05, P =0.01 and 0.09±0.09 versus 0.15±0.05, P =0.01); however, only 40 (58%) patients of the cohort showed significant BOLD‐CVR impairment. Conversely, there was no difference in mean BOLD‐CVR values between healthy patients and patients with ICA stenosis, although 5 (14%) patients with ICA stenosis showed a significant BOLD‐CVR impairment. No significant BOLD‐CVR difference was discernible between patients with hemodynamic ischemic infarcts versus those with embolic infarct distribution (0.11±0.08 versus 0.13±0.06, P =0.12). Conclusions Comprehensive BOLD‐CVR mapping allows for identification of hemodynamically relevant symptomatic unilateral carotid artery stenosis or occlusion.

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MS537 IMPACT OF PLAQUE HAEMORRHAGE ON PLAQUE STRESS IN PATIENTS WITH CAROTID ARTERY DISEASE – A PATIENT-SPECIFIC MAGNETIC RESONANCE IMAGING STUDY

Atherosclerosis Supplements ◽

10.1016/s1567-5688(10)71037-0 ◽

2010 ◽

Vol 11 (2) ◽

pp. 218

Author(s):

U. Sadat ◽

Z. Teng ◽

V. Young ◽

J. Gillard

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Carotid Artery ◽

Carotid Artery Disease ◽

Imaging Study ◽

Patient Specific ◽

Magnetic Resonance Imaging Study ◽

Resonance Imaging ◽

Artery Disease

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Deformation Measurements by Echocardiography versus Late Enhancement Magnetic Resonance Imaging in Patients with Coronary Artery Disease

European Cardiology Review ◽

10.15420/ecr.2012.8.2.101 ◽

2012 ◽

Vol 8 (2) ◽

pp. 101

Author(s):

Brage H Amundsen ◽

Anders Thorstensen ◽

Asbjørn Støylen ◽

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Keyword(s):

Magnetic Resonance Imaging ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Magnetic Resonance ◽

Late Enhancement ◽

High Temporal Resolution ◽

Resonance Imaging ◽

Deformation Imaging ◽

Artery Disease ◽

Deformation Measurements

The aim of this article is to discuss the present and future potential of deformation imaging by echocardiography and scar visualisation by magnetic resonance imaging (MRI) in patients with coronary artery disease (CAD). The two methods are clearly different: one is concerned with function, the other with morphology. Echocardiography, with its versatility of methods and high applicability, will continue to be the workhorse in cardiac imaging of patients with CAD. Important additional information can be extracted from deformation imaging methods, especially due to the high temporal resolution in tissue Doppler. Deformation measurements in 3D images are still limited by their lower resolution compared with 2D but will continue to improve. The standardisation of image analysis and the collaboration within the echocardiographic community to conduct larger studies will be important tasks in the attempt to establish evidence for the new methods. Late enhancement MRI is a method with unique properties and will continue to be an important alternative in selected patients and settings, as well as an invaluable research tool.

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