scholarly journals Myocardial strain analysis with CMR in cardiotoxicity patients using deformation field analysis: Comparison to healthy volunteers and heart transplant patients

Author(s):  
Abraham Bogachkov ◽  
Kai Lin ◽  
Benjamin H Freed ◽  
Michael Markl ◽  
James C Carr ◽  
...  
2020 ◽  
Author(s):  
Thomas D Ryan ◽  
Hugo R. Martinez ◽  
Ralph Salloum ◽  
Erin Wright ◽  
Lauren Bueche ◽  
...  

Abstract Background: Craniospinal irradiation (CSI) is part of the treatment of central nervous system (CNS) tumors and is associated with cardiovascular disease in adults. Global myocardial strain analysis including longitudinal peak systolic strain (GLS), circumferential peak systolic strain (GCS) and radial peak systolic strain (GRS) can reveal subclinical cardiac dysfunction.Methods: Retrospective, single-center study in patients managed with CSI vs. age-matched controls. Clinical data and echocardiography, including myocardial strain analysis, were collected at early (<12 months) and late ( 12 months) after completion of CSI.Results: Echocardiograms were available in 20 early and 34 late patients. Patients at the late time point were older (21.7±10.4 vs. 13.3 9.6 years), and further out from CSI (13.1±8.8 vs. 0.2±0.3 years). Standard echocardiographic parameters were normal for all subjects. For the early time, CSI vs. control: GLS was -16.8 3.6% vs. -21.3 4.0% (p=0.0002), GCS was -22.5 5.2% vs. -21.3 3.4% (p=0.28), and GRS was 21.8 11.0% vs. 26.9 7.7% (p=0.07). At the late time point, CSI vs. control: GLS was -16.2 5.4% vs. -21.6 3.7% (p<0.0001), GCS was -20.9 6.8% vs. -21.9 3.5% (p=0.42), and GRS was 22.5 10.0% vs. 27.3 8.3% (p=0.03). Radiation type (proton vs. photon), and radiation dose (<30 Gy vs. 30 Gy) did not impact any parameter.Conclusions: Subclinical cardiac systolic dysfunction by GLS is present both early and late after CSI. These results argue for inclusion of baseline cardiovascular assessment and early initiation of longitudinal follow-up post CSI.


Author(s):  
M.J. Ledesma-Carbayo ◽  
A. Santos ◽  
J. Kybic ◽  
P. Mahia-Casado ◽  
M.A. Garcia-Feernandez ◽  
...  

2017 ◽  
Vol 27 (11) ◽  
pp. 4661-4671 ◽  
Author(s):  
Julian A. Luetkens ◽  
Ulrike Schlesinger-Irsch ◽  
Daniel L. Kuetting ◽  
Darius Dabir ◽  
Rami Homsi ◽  
...  

2006 ◽  
Vol 7 ◽  
pp. S42-S42
Author(s):  
G DISALVO ◽  
E PIEGARI ◽  
G PACILEO ◽  
B CASTALDI ◽  
P GOLINO ◽  
...  

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