Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema

2017 ◽  
Vol 27 (11) ◽  
pp. 4661-4671 ◽  
Author(s):  
Julian A. Luetkens ◽  
Ulrike Schlesinger-Irsch ◽  
Daniel L. Kuetting ◽  
Darius Dabir ◽  
Rami Homsi ◽  
...  
Keyword(s):  
Feature Tracking ◽  
Acute Myocarditis ◽  
Myocardial Strain ◽  
Strain Analysis ◽  
Diagnostic Value ◽  
Myocardial Oedema ◽  
Myocardial Strain Analysis

scholarly journals CMR-derived myocardial strain analysis differentiates ischemic and dilated cardiomyopathy - A propensity score-matched study

2021 ◽  
Author(s):  
Julia Vietheer ◽  
Lehmann Lena ◽  
Claudia Unbehaun ◽  
Ullrich Fischer-Rasokat ◽  
Jan Sebastian Wolter ◽  
...  
Keyword(s):  
Propensity Score ◽  
Dilated Cardiomyopathy ◽  
Propensity Score Matching ◽  
Feature Tracking ◽  
Global Longitudinal Strain ◽  
Myocardial Strain ◽  
Radial Strain ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Myocardial Strain Analysis

Abstract Purpose Left ventricular (LV) longitudinal, circumferential, and radial motion can be measured using feature tracking of cardiac magnetic resonance (CMR) images. The aim of our study was to detect differences in LV mechanics between patients with dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) who were matched using a propensity score-based model. Methods Between April 2017 and October 2019, 1224 patients were included in our CMR registry, among them 141 with ICM and 77 with DCM. Propensity score matching was used to pair patients based on their indexed end-diastolic volume (EDVi), ejection fraction (EF), and septal T1 relaxation time. Feature tracking provided six parameters for global longitudinal, circumferential, and radial strain with corresponding strain rates. Results Propensity score matching yielded 72 patients in each group (DCM mean age 58.6 ± 11.6 years, 15 females; ICM mean age 62.6 ± 13.2 years, 11 females, p = 0.084 and 0.44 respectively; LV-EF 32.2 ± 13.5% vs. 33.8 ± 12.1%, p = 0.356; EDVi 127.2 ± 30.7 ml/m² vs. 121.1 ± 41.8 ml/m², p = 0.251; native T1 values 1165 ± 58 ms vs. 1167 ± 70 ms, p = 0.862). There was no difference in global longitudinal strain between DCM and ICM patients (-10.9 ± 5.5% vs. -11.2 ± 4.7%, p = 0.72), whereas in DCM patients there was a significant reduction in global circumferential strain (-10.0 ± 4.5% vs. -12.2 ± 4.7%, p = 0.002) and radial strain (17.1 ± 8.51 vs. 21.2 ± 9.7%, p = 0.039). Conclusion Our data suggest that ICM and DCM patients have inherently different myocardial mechanics, even if phenotypes are similar. The ability to discriminate these two conditions may aid in developing additional prognostic and therapeutic strategies in the future.

scholarly journals CMR-derived myocardial strain analysis differentiates ischemic and dilated cardiomyopathy—a propensity score-matched study

2021 ◽  
Author(s):  
Julia Vietheer ◽  
Lena Lehmann ◽  
Claudia Unbehaun ◽  
Ulrich Fischer-Rasokat ◽  
Jan Sebastian Wolter ◽  
...  
Keyword(s):  
Propensity Score ◽  
Dilated Cardiomyopathy ◽  
Propensity Score Matching ◽  
Feature Tracking ◽  
Global Longitudinal Strain ◽  
Myocardial Strain ◽  
Radial Strain ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Myocardial Strain Analysis

AbstractLeft ventricular (LV) longitudinal, circumferential, and radial motion can be measured using feature tracking of cardiac magnetic resonance (CMR) images. The aim of our study was to detect differences in LV mechanics between patients with dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) who were matched using a propensity score-based model. Between April 2017 and October 2019, 1224 patients were included in our CMR registry, among them 141 with ICM and 77 with DCM. Propensity score matching was used to pair patients based on their indexed end-diastolic volume (EDVi), ejection fraction (EF), and septal T1 relaxation time (psmatch2 module L Feature tracking provided six parameters for global longitudinal, circumferential, and radial strain with corresponding strain rates in each group. Strain parameters were compared between matched pairs of ICM and DCM patients using paired t tests. Propensity score matching yielded 72 patients in each group (DCM mean age 58.6 ± 11.6 years, 15 females; ICM mean age 62.6 ± 13.2 years, 11 females, p = 0.084 and 0.44 respectively; LV-EF 32.2 ± 13.5% vs. 33.8 ± 12.1%, p = 0.356; EDVi 127.2 ± 30.7 ml/m2 vs. 121.1 ± 41.8 ml/m2, p = 0.251; native T1 values 1165 ± 58 ms vs. 1167 ± 70 ms, p = 0.862). There was no difference in global longitudinal strain between DCM and ICM patients (− 10.9 ± 5.5% vs. − 11.2 ± 4.7%, p = 0.72), whereas in DCM patients there was a significant reduction in global circumferential strain (− 10.0 ± 4.5% vs. − 12.2 ± 4.7%, p = 0.002) and radial strain (17.1 ± 8.51 vs. 21.2 ± 9.7%, p = 0.039). Our data suggest that ICM and DCM patients have inherently different myocardial mechanics, even if phenotypes are similar. Our data show that GCS is significantly more impaired in DCM patients. This feature may help in more thoroughly characterizing cardiomyopathy patients.

P876Cardiac magnetic resonance based feature-tracking myocardial strain analysis in MINOCA patients

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
L Szabo ◽  
V Horvath ◽  
Z Dohy ◽  
C Czimbalmos ◽  
A Toth ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Feature Tracking ◽  
Acute Myocarditis ◽  
Myocardial Strain ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Healthy Controls ◽  
Regional Heterogeneity ◽  
Significant Difference

Abstract The diagnostic performance of cardiac magnetic resonance (CMR) based deformation imaging (feature tracking - FT) has been demonstrated in various groups of patients including acute myocardial infarction and acute myocarditis. However, the capability of this method to distinguish between patients with the working diagnosis of MINOCA is yet to be tested. We aimed to compare standard CMR parameters and investigate the differential diagnostic value of CMR-FT myocardial strain in pts with the working diagnosis of MINOCA. From our consecutive register of pts with troponin positive acute coronary syndrome (n=234 pts) we enrolled 100 pts (47.7±14 y; 51 male) in this study.Twenty-five pts were selected randomly from each group of acute myocardial infarction (MI), acute myocarditis, Tako-Tsubo cardiomyopathy (TTC) and pts without structural alteration on CMR, and an additional group of healthy control (n=20, 46±8.2 y; 12 male). Standard CMR parameters such as left ventricular ejection fraction (LVEF), end-diastolic (LVEDVi) and end-systolic (LVESVi) volumes, myocardial mass were assessed and compared between the groups. We performed CMR-FT analysis of the left ventricle, including: global longitudinal (GLS), circumferential (GCS), standard deviation (SD) of the peak circumferential (CS) strain furthermore mechanical dispersion (MD), defined as the SD of the time-to-peak circumferential (MDC) strain of the LV segments expressed as percent of the cardiac cycle. LVEF was lower (44±9.1%) and LVESVi (52.5±12.9ml/m2) was higher in TTC pts compared to all other groups (p<0.001). The LVEF, LVEDVi and LVESVi parameters did not show significant difference between MI and myocarditis pts (LVEF 56.5±7% vs 55±6.6%; LVEDVi 85.4±14.8 vs 92.7±10.7ml/m2; LVESVi 37.7±11.4 vs 41.5±9.1ml/m2). GLS and GRS were significantly reduced in TTC pts (−11.4±4.8%; 43.09±12.5%) compared to all other groups (p<0.001). GCS was impaired in pts with TTC, acute myocarditis and MI compared to healthy controls (−14±3.7 vs −18.7±3.7 vs −19.1±3.8 vs −23.2±3.1%, p<0.001), however there was no significant difference between myocarditis and MI pts. SD of the peak CS was lower in myocarditis compared to other groups (p<0.001). MDC was elevated in TTC and MI compared to myocarditis and healthy controls (16.3±5 vs 13.3±3.4 vs 8.1±3.3 vs 9.46±3.5% p<0.05). There was no significant difference between healthy controls and patients without structural alterations in any strain parameter. Strain analysis of a TTC patient Feature tracking analysis may enable differentiation between patients with MINOCA. TTC reduces global myocardial strain of the left ventricle and causes regional heterogeneity of the left ventricular contraction. Although standard volumetric CMR parameters and CMR based global strain values have limited capability to distinguish between MI and myocarditis with preserved ejection fraction, regional heterogeneity, expressible in MDC is significantly elevated in MI compared to myocarditis and healthy controls. Acknowledgement/Funding Project no. NVKP_16-1-2016-0017 has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary

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