scholarly journals Biphasic parapharyngeal synovial sarcoma : A cytologic and immunocytologic report of a case

CytoJournal ◽  
2006 ◽  
Vol 3 ◽  
pp. 20 ◽  
Author(s):  
Bijan Khademi ◽  
Yahya Daneshbod ◽  
Shahrzad Negahban ◽  
Khosrow Daneshbod ◽  
Massud Kaviani ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Spindle Cell ◽  
Parapharyngeal Space ◽  
Neck Region ◽  
Needle Aspiration ◽  
Cervical Region ◽  
Upper Aerodigestive Tract ◽  
Large Tumor ◽  
Arm Pain ◽  
The Right

Background: Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space. There is no previous cytologic report of synovial sarcoma of parapharynx. The cytologic and immunocytochemical findings of a parapharyngeal biphasic synovial sarcoma together with diagnostic pitfalls are described. Case report: A 21-year-old girl presented with a 6-month history of progressive right arm pain, neck mass and upper aerodigestive tract obstruction. On physical examination there was a large painless mass arising from the right-sided parapharyngeal space causing airway obstruction. Initial magnetic resonance imaging (MRI) revealed a large tumor in the right-sided parapharyngeal space. Fine needle aspiration through cervical region was performed and was reported as benign spindle cell tumor. Smears were cellular and composed mostly of tight and loose clusters of spindle cells. Epitheloid cells could also be identified intermingled with them. She underwent near total resection of the tumor. Pathologic report disclosed the diagnosis of synovial sarcoma. She then received postoperative adjuvant external radiotherapy. Conclusion: Due to rarity of this tumor in this region and nonspecific cytologic features, we could not differentiate this tumor from the other more common spindle cell neoplasms. Considering synovial sarcoma in this region and immunocytochemistry can be helpful in rendering a correct initial diagnosis of this tumor.

scholarly journals Synovial sarcoma: case report

2017 ◽  
Vol 65 (3) ◽  
pp. 260-264
Author(s):  
Isabella Lima Arrais RIBEIRO ◽  
Larissa Cavalcanti MONTEIRO ◽  
Ana Carolina Rodrigues de MELO ◽  
Tácio Candeia LYRA ◽  
Julio Cesar Campos FERREIRA FILHO ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Synovial Sarcoma ◽  
Fibrous Tissue ◽  
Treatment Protocol ◽  
Neck Region ◽  
Cervical Region ◽  
Histopathological Analysis ◽  
Parotid Region ◽  
Synovial Sarcomas

ABSTRACT Introduction: Synovial sarcomas are rare and aggressive neoplasms located in the head and neck region and usually occurs in young adults. Presentation of case: This report presents a case of synovial sarcoma in a 15-year-old male patient who sought medical treatment for painful symptoms and associated dysphagia. The lesion was nodular, extensive, localized in the parotid region, and extended to the left cervical region. The patient was treated in a referral hospital with a treatment protocol that initially included chemotherapy for six months and surgery to attempt to excise the lesion, but the surgery was ineffective because removal could have damaged important vital structures. The Computed Tomography scan showed a hypodense area with diffuse growth and no involvement of the facial bones and the histopathological analysis revealed pleomorphic and oval spindle cells with rounded epithelial cells that formed nests surrounded by fibrous tissue. The Immunohistochemistry analysis was conclusive for the diagnosis of a high-grade SS in the parotid and left cervical regions. The medical team opted for palliative treatment with cervical radiotherapy. The patient remained hospitalized for four months after the surgery and died after 15 months since the diagnosis for compromise of airway by fast tumor growth. Conclusion: The synovial sarcoma, when diagnosed late may reduce the survival of patients because of the complications that tumor growth can bring to the prognosis and quality of life.

scholarly journals Inflammatory Myofibroblastic Tumour of the Skull Base

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Jean-Philippe Maire ◽  
Sandrine Eimer ◽  
François San Galli ◽  
Valérie Franco-Vidal ◽  
Sigolène Galland-Girodet ◽  
...  
Keyword(s):  
Skull Base ◽  
Cavernous Sinus ◽  
Sella Turcica ◽  
Neck Region ◽  
Conformal Radiotherapy ◽  
Large Tumor ◽  
Sphenoidal Sinus ◽  
Radiological Response ◽  
Inflammatory Myofibroblastic Tumors ◽  
The Right

Inflammatory myofibroblastic tumors (IMTs) are rare benign clinical and pathological entities. IMTs have been described in the lungs, abdomen, retroperitoneum, and extremities but rarely in the head and neck region. A 38-year-old man presented with headache, right exophthalmia, and right 6th nerve palsy. A CT scan revealed enlargement of the right cavernous sinus and osteolytic lesions of the right sphenoid and clivus. MR imaging showed a large tumor of the skull base which was invading the sella turcica, right cavernous sinus, and sphenoidal sinus. A biopsy was performed and revealed an IMT. Corticosteroids were given for 3 months but were inefficient. In the framework of our pluridisciplinary consultation, fractionated conformal radiotherapy (FRT) was indicated at a low dose; 20 Gy in 10 fractions of 2 Gy over 12 days were delivered. Clinical response was complete 3 months after FRT. Radiological response was subtotal 6 months after FRT. Two years later, the patient is well.

scholarly journals Spindle Cell Lipoma of the Parapharyngeal Space: First Report of a Case

2001 ◽  
Vol 80 (4) ◽  
pp. 244-250 ◽  
Author(s):  
Ingo Baumann ◽  
Florian Dammann ◽  
Hans Peter Horny ◽  
Peter Karl Plinkert
Keyword(s):  
Spindle Cell ◽  
Parapharyngeal Space ◽  
Subcutaneous Tissue ◽  
Resonance Imaging ◽  
Spindle Cell Lipoma ◽  
Lipomatous Tumor ◽  
Pharyngeal Muscles ◽  
Parapharyngeal Tumor ◽  
The Right ◽  
Total Parotidectomy

Spindle cell lipomas are usually located in the subcutaneous tissue of the back, shoulders, and neck. To our knowledge, the presence of such a tumor in the parapharyngeal space has not yet been described. We evaluated a 45-year-old man with a tender swelling of the right parotid area that had reached the submandibular area. Clinical examination and magnetic resonance imaging revealed the presence of a tumor that coated the parotid area laterally and extended into the center of the parapharyngeal space, thus causing a dislocation of the pharyngeal muscles and mucosa. We performed a total parotidectomy and submandibulectomy on the right side and extirpated the parapharyngeal tumor. We were able to spare the facial nerve, and no facial paralysis occurred. Histologic examination revealed an atypical lipomatous tumor with a remarkably large portion of spindles.

Neck exploration for a huge synovial sarcoma, case report and literature review

2020 ◽  
pp. 1-8
Author(s):  
Ahmed Siddique Ammar ◽  
Rizwan Khalid
Keyword(s):  
Neck Dissection ◽  
Synovial Sarcoma ◽  
Radical Neck Dissection ◽  
Needle Aspiration ◽  
Cervical Lymph Nodes ◽  
Posterior Triangle ◽  
Surgical Ward ◽  
Functional Neck Dissection ◽  
Needle Aspiration Cytology ◽  
The Right

Abstract A 47-year-old woman presented in the outpatient department of EAST Surgical ward of MAYO Hospital Lahore, Pakistan, on February 2019 with complaint of swelling in the front section of the neck since five months which increased gradually in size and had been causing pain since two months. She had no comorbidities and insignificant family history. Examination revealed a 23×20 cm mass on the right side of the posterior triangle of the neck. Fine Needle Aspiration Cytology (FNAC) was inconclusive and CT of the neck showed a huge mass on the right side of the neck with cervical lymph nodes. Exploration was planned, and modified radical neck dissection Type III (Also known as Functional Neck dissection) was performed. The biopsy revealed synovial sarcoma of the neck. The patient’s post-operative condition was satisfactory and she was discharged on the fifth post-operative day. Continuous...

scholarly journals Evaluation of conditional treatment effects of adjuvant treatments on patients with synovial sarcoma using Bayesian subgroup analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sung Wook Seo ◽  
Jisoo Kim ◽  
Jihye Son ◽  
Sungbin Lim
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
High Risk ◽  
Propensity Score ◽  
Synovial Sarcoma ◽  
Treatment Effects ◽  
Spindle Cell ◽  
Large Tumor ◽  
Subgroup Analyses ◽  
Risk Patients

Abstract Background The impact of adjuvant chemotherapy or radiation therapy on the survival of patients with synovial sarcoma (SS), which is a rare soft-tissue sarcoma, remains controversial. Bayesian statistical approaches and propensity score matching can be employed to infer treatment effects using observational data. Thus, this study aimed to identify the individual treatment effects of adjuvant therapies on the overall survival of SS patients and recognize subgroups of patients who can benefit from specific treatments using Bayesian subgroup analyses. Methods We analyzed data from patients with SS obtained from the surveillance, epidemiology, and end results (SEER) public database. These data were collected between 1984 and 2014. The treatment effects of chemotherapy and radiation therapy on overall survival were evaluated using propensity score matching. Subgroups that could benefit from radiation therapy or chemotherapy were identified using Bayesian subgroup analyses. Results Based on a stratified Kaplan–Meier curve, chemotherapy exhibited a positive average causal effect on survival in patients with SS, whereas radiation therapy did not. The optimal subgroup for chemotherapy includes the following covariates: older than 20 years, male, large tumor (longest diameter > 5 cm), advanced stage (SEER 3), extremity location, and spindle cell type. The optimal subgroup for radiation therapy includes the following covariates: older than 20 years, male, large tumor (longest diameter > 5 cm), early stage (SEER 1), extremity location, and biphasic type. Conclusion In this study, we identified high-risk patients whose variables include age (age > 20 years), gender, tumor size, tumor location, and poor prognosis without adjuvant treatment. Radiation therapy should be considered in the early stages for high-risk patients with biphasic types. Conversely, chemotherapy should be considered for late-stage high-risk SS patients with spindle cell types.

Primary monophasic breast synovial sarcoma in a female patient

2021 ◽  
Vol 14 (8) ◽  
pp. e242313
Author(s):  
Quan Do ◽  
Vatsala Katiyar ◽  
Andrea Breaux ◽  
Vikas Singh
Keyword(s):  
Synovial Sarcoma ◽  
Soft Tissues ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
Neck Region ◽  
Fusion Transcript ◽  
Spindle Cell Carcinoma ◽  
Head And Neck Region ◽  
Immunohistochemistry Staining ◽  
Uncommon Location

Synovial sarcoma (SS) is a rare soft tissue sarcoma usually arising in the deep soft tissues of the limbs, trunk, and head and neck region. Due to its rarity, diagnosis can be difficult to establish, especially when it involves an uncommon location like the breast. In this case report, we describe a young woman who was found to have primary SS of the breast. Initial immunohistochemistry staining was focally positive for cytokeratin and S100 and she was misdiagnosed with atypical spindle cell carcinoma. Due to the unusual presentation, further testing was performed which showed TLE1 and epithelial membrane antigen positivity, establishing the diagnosis of SS of the breast. A FISH was later sent out and was positive for SS18-SSX fusion transcript. This case highlights the importance of considering rare histopathology in breast lesions and using additional staining and cytogenetics to confirm diagnosis.

Primary Intravascular Synovial Sarcoma: Case Report

2012 ◽  
Vol 15 (5) ◽  
pp. 297 ◽  
Author(s):  
Osman Nuri Tuncer ◽  
Ozan Erbasan ◽  
İlhan Golbasi
Keyword(s):  
Synovial Sarcoma ◽  
Spindle Cell ◽  
English Literature ◽  
Superior Vena ◽  
Vena Cava ◽  
Soft Tissue Sarcomas ◽  
Chromosomal Translocation ◽  
Cell Tumor ◽  
The Right

Synovial sarcoma (SS), a mesenchymal spindle cell tumor, displays variable epithelial differentiation, including glandular formation, and features a specific chromosomal translocation, t(X;18)(p11;q11). SS accounts for 5% to 10% of soft-tissue sarcomas. These tumors occur mostly in the joints, especially near the knee, but they also occur in other locations. Primary intravascular SS (IVSS) are extremely rare; only 6 well-documented cases have been reported in the English literature. We describe a new case of primary IVSS of the superior vena cava (SVC) in a 16-year-old boy. A transthoracic echocardiogram confirmed a large (4.8 ◊ 4.6 cm) circumscribed mass filling the right atrium, as well as a moderate pericardial effusion. The mass extended from the SVC to the tricuspid valve but did not prevent valve coaptation. Surgery via a transatrial approach revealed a huge mass (8 to 12 cm) attached to the SVC via a 5-mm pedicle. The tumor was excised, and the patient experienced an uneventful postoperative course. Fluorescence in situ hybridization analysis revealed the presence of the SS-specific translocation.

scholarly journals Multiple Retroperitoneal Paragangliomas: An Uncommon Entity

2017 ◽  
Vol 9 (1) ◽  
pp. 20-23
Author(s):  
Ashu Singh ◽  
Deep Shikha ◽  
Shipra Agarwal ◽  
Shyam Lata Jain ◽  
NS Hadke
Keyword(s):  
Case Reports ◽  
English Literature ◽  
Neck Region ◽  
Needle Aspiration ◽  
Neuroendocrine Neoplasm ◽  
Familial Association ◽  
Retroperitoneal Tumors ◽  
The Right ◽  
The Masses ◽  
Enhanced Computed Tomography

ABSTRACT Introduction Paragangliomas are neuroendocrine tumors and occur commonly in head and neck region and less frequently in the retroperitoneum. Multifocal paragangliomas are even rarer and highly suggestive of familial disease. To the best of our search, there are only two case reports of multiple retroperitoneal paragangliomas with no known familial association. This is the third report of this kind in the English literature. Case report A young adult with no significant past or family history presented with abdominal pain and anorexia. Abdominal examination revealed a soft nontender mass in the right hypochondrium. Contrast-enhanced computed tomography showed multiple retroperitoneal mass lesions. A clinicoradiological diagnosis of multicentric Castleman's disease/Lymphoma was made. Guided fine needle aspiration of the mass was suggestive of a neuroendocrine neoplasm. Tru-cut biopsy showed features of paraganglioma. Following this, the masses were excised and the diagnosis of paraganglioma was confirmed. Conclusion Multicentric retroperitoneal paragangliomas without any familial association are very rare with only two case reports in the English literature. Lack of symptoms makes the diagnosis difficult and also makes our case unique. Biopsy from paragangliomas and surgical intervention are known to cause life-threatening complications, such as profuse bleeding and abrupt changes in blood pressure. Hence, paragangliomas should be considered as a possibility, even if a remote one, in case of multicentric retroperitoneal tumors. This case also highlights the importance of cytology in the early diagnosis of retroperitoneal masses. How to cite this article Singh A, Shikha D, Agarwal S, Khurana N, Jain SL, Hadke NS. Multiple Retroperitoneal Paragangliomas: An Uncommon Entity. World J Endoc Surg 2017;9(1):20-23.

scholarly journals Pediatric extramammary myofibroblastoma in the head and neck region: a case report

2020 ◽  
Vol 6 (5) ◽  
pp. 995
Author(s):  
Sunil K. C. ◽  
B. Y. Praveen Kumar ◽  
Varna Ravindran M. K. ◽  
Kiran Mali
Keyword(s):  
Soft Tissues ◽  
Spindle Cell ◽  
Neck Region ◽  
Lateral Border ◽  
Marked Variability ◽  
Spindle Cell Tumours ◽  
Mesenchymal Neoplasm ◽  
Spindle Cell Tumour ◽  
Benign Tumours ◽  
The Right

<p>A rare form of mesenchymal neoplasm that typically presents in older men and women is mammary myofibroblastoma. Even so rarely, these benign tumours may occur outside of the breasts in soft tissues; which then are called mammary-type myofibroblastoma. There can be marked variability in the histological composition of these benign spindle cell tumours. Along the milk line is the commonest presentation of these extramammary myofibroblastoma. Here we have an 8 years old female patient presented to the department of otorhinolaryngology with a painless, fusiform swelling over the right lateral aspect of tongue in the past 6 months. Intra oral examination revealed a non-tender, non-ulcerated fusiform shaped mass approximately 3×2 cm firm in consistency arising from the right lateral border of the tongue. FNAC was done which showed spindle cell tumour tongue. The lesion was diagnosed as mammary type myofibroblastoma on immunohistochemistry.</p>

scholarly journals A Unique Case of a Sublingual-Space Schwannoma Arising from the Mylohyoid Nerve

2010 ◽  
Vol 89 (7) ◽  
pp. E31-E33 ◽  
Author(s):  
Kavita Malhotra Pattani ◽  
Kevin Dowden ◽  
Cherie-Ann O. Nathan
Keyword(s):  
Spindle Cell ◽  
Needle Aspiration ◽  
Mylohyoid Muscle ◽  
Unique Case ◽  
Aspiration Cytology ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Mylohyoid Nerve ◽  
Needle Aspiration Cytology ◽  
The Right

We describe a unique case of a sublingual-space schwannoma presenting as a painless, 3 × 2-cm enlarging mass in the oral cavity of a 63-year-old man. Computed tomography demonstrated a distinct, well-encapsulated mass in the right side of the floor of the mouth. Findings on fine-needle aspiration cytology were consistent with a pleomorphic adenoma. Transoral excision was performed. Intraoperatively, the mass appeared to involve the nerve to the mylohyoid muscle. Upon removal, the gross tumor measured 4.4 × 3.5 × 2.5 cm. On microscopic examination, the spindle-cell neoplasm was found to be consistent with a schwannoma. Schwannomas of the sublingual space are exceedingly rare. Moreover, to the best of our knowledge, this case represents the first published occurrence of a schwannoma that arose from the mylohyoid nerve.

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