scholarly journals Synovial sarcoma: case report

2017 ◽  
Vol 65 (3) ◽  
pp. 260-264
Author(s):  
Isabella Lima Arrais RIBEIRO ◽  
Larissa Cavalcanti MONTEIRO ◽  
Ana Carolina Rodrigues de MELO ◽  
Tácio Candeia LYRA ◽  
Julio Cesar Campos FERREIRA FILHO ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Synovial Sarcoma ◽  
Fibrous Tissue ◽  
Treatment Protocol ◽  
Neck Region ◽  
Cervical Region ◽  
Histopathological Analysis ◽  
Parotid Region ◽  
Synovial Sarcomas

ABSTRACT Introduction: Synovial sarcomas are rare and aggressive neoplasms located in the head and neck region and usually occurs in young adults. Presentation of case: This report presents a case of synovial sarcoma in a 15-year-old male patient who sought medical treatment for painful symptoms and associated dysphagia. The lesion was nodular, extensive, localized in the parotid region, and extended to the left cervical region. The patient was treated in a referral hospital with a treatment protocol that initially included chemotherapy for six months and surgery to attempt to excise the lesion, but the surgery was ineffective because removal could have damaged important vital structures. The Computed Tomography scan showed a hypodense area with diffuse growth and no involvement of the facial bones and the histopathological analysis revealed pleomorphic and oval spindle cells with rounded epithelial cells that formed nests surrounded by fibrous tissue. The Immunohistochemistry analysis was conclusive for the diagnosis of a high-grade SS in the parotid and left cervical regions. The medical team opted for palliative treatment with cervical radiotherapy. The patient remained hospitalized for four months after the surgery and died after 15 months since the diagnosis for compromise of airway by fast tumor growth. Conclusion: The synovial sarcoma, when diagnosed late may reduce the survival of patients because of the complications that tumor growth can bring to the prognosis and quality of life.

scholarly journals Pediatric Synovial Sarcoma in the Retropharyngeal Space: A Rare and Unusual Presentation

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Sanjay Vaid ◽  
Neelam Vaid ◽  
Sanjay Desai ◽  
Varada Vaze
Keyword(s):  
Head And Neck ◽  
Synovial Sarcoma ◽  
Pediatric Population ◽  
Neck Region ◽  
Retropharyngeal Space ◽  
Imaging Findings ◽  
Head And Neck Region ◽  
English Medical Literature ◽  
Synovial Sarcomas ◽  
First Time

Synovial sarcomas in the head and neck are extremely rare tumors, especially in the pediatric population. 3–5% of synovial sarcomas occur in the head and neck region displaying varied imaging and histopathological features resulting in frequent misdiagnosis. These tumors have a poor prognosis; hence early diagnosis and accurate classification based on imaging, histopathology, and immunohistochemistry are critical for prompt treatment. To the best of our knowledge, imaging findings of pediatric retropharyngeal lipomatous synovial sarcoma have not been reported to date in English medical literature. We report, for the first time, a rare case of retropharyngeal lipomatous synovial sarcoma in a ten-year-old child and discuss the case-specific imaging findings in our patient using magnetic resonance imaging and computed tomography.

Synovial sarcoma of the frontal sinus

2005 ◽  
Vol 103 (6) ◽  
pp. 1077-1080 ◽  
Author(s):  
Gary L. Gallia ◽  
Daniel M. Sciubba ◽  
Christine L. Hann ◽  
Siva P. Raman ◽  
William H. Westra ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Frontal Sinus ◽  
Neck Region ◽  
Common Site ◽  
Soft Tissue Lesion ◽  
Head And Neck Region ◽  
Content Type ◽  
Synovial Sarcomas ◽  
Fine Print

✓ Synovial sarcoma is a soft-tissue lesion occurring predominantly in the extremities of young adults. Although the head and neck region is the second most common site of involvement, synovial sarcoma has rarely been reported in the paranasal sinus. The authors present a case of synovial sarcoma arising from the frontal sinus and review the literature of synovial sarcomas arising from the paranasal sinuses.

scholarly journals Primary soft palate biphasic synovial sarcoma - case report and literature review

2021 ◽  
Vol 11 (44) ◽  
pp. 174-180
Author(s):  
Ionut Tanase ◽  
Mihaela Neagu ◽  
George Dascalescu
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Synovial Sarcoma ◽  
Soft Palate ◽  
Postoperative Radiotherapy ◽  
Neck Region ◽  
Complete Removal ◽  
Head And Neck Region ◽  
Pleomorphic Sarcoma ◽  
Synovial Sarcomas

Abstract BACKGROUND. Synovial sarcomas of the soft tissue are a particular type of sarcomas that rarely appear in the head and neck region. CASE REPORT AND COMMENTS. We present the case of a 27-year-old patient diagnosed in 2017 with soft palate biphasic synovial sarcoma who presented with recurrent microepistaxis, nasal obstruction, left cephalalgia and aural fullness in the left ear. The clinical examination showed a tumor with approximately 4/6 cm in diameter, covered with sero-sanguinolent secretions, pulsating in nature, completely obstructing the left choana. The surgical treatment consisted of complete removal of the tumor under endoscopic guidance with electrocauterization of the insertion area, without further postoperative radiotherapy. The histopathological aspect was suggestive for pleomorphic sarcoma, poorly differentiated, confirming the local recurrence of the tumor. The patient also presented lung metastasis from undifferentiated malignant tumor. CONCLUSION. The particularity of this case is represented by the extremely rare occurrence of synovial sarcoma in the head and neck region, especially at the level of the soft palate. Complete resection of the tumor with negative margins represent the mainstay of treatment, associated with adjuvant radiotherapy, with an important role in improving disease-specific survival.

scholarly journals Biphasic parapharyngeal synovial sarcoma : A cytologic and immunocytologic report of a case

CytoJournal ◽  
2006 ◽  
Vol 3 ◽  
pp. 20 ◽  
Author(s):  
Bijan Khademi ◽  
Yahya Daneshbod ◽  
Shahrzad Negahban ◽  
Khosrow Daneshbod ◽  
Massud Kaviani ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Spindle Cell ◽  
Parapharyngeal Space ◽  
Neck Region ◽  
Needle Aspiration ◽  
Cervical Region ◽  
Upper Aerodigestive Tract ◽  
Large Tumor ◽  
Arm Pain ◽  
The Right

Background: Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space. There is no previous cytologic report of synovial sarcoma of parapharynx. The cytologic and immunocytochemical findings of a parapharyngeal biphasic synovial sarcoma together with diagnostic pitfalls are described. Case report: A 21-year-old girl presented with a 6-month history of progressive right arm pain, neck mass and upper aerodigestive tract obstruction. On physical examination there was a large painless mass arising from the right-sided parapharyngeal space causing airway obstruction. Initial magnetic resonance imaging (MRI) revealed a large tumor in the right-sided parapharyngeal space. Fine needle aspiration through cervical region was performed and was reported as benign spindle cell tumor. Smears were cellular and composed mostly of tight and loose clusters of spindle cells. Epitheloid cells could also be identified intermingled with them. She underwent near total resection of the tumor. Pathologic report disclosed the diagnosis of synovial sarcoma. She then received postoperative adjuvant external radiotherapy. Conclusion: Due to rarity of this tumor in this region and nonspecific cytologic features, we could not differentiate this tumor from the other more common spindle cell neoplasms. Considering synovial sarcoma in this region and immunocytochemistry can be helpful in rendering a correct initial diagnosis of this tumor.

scholarly journals The First Ever Reported Case of Primary Synovial Sarcoma of Scalp

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Biplab Mishra ◽  
Saurabh Singhal ◽  
Deepak Prakash Bhirud ◽  
Nitesh Kumar ◽  
Saumyaranjan Mallick
Keyword(s):  
Synovial Sarcoma ◽  
Neck Region ◽  
Young Female ◽  
Rare Entity ◽  
Extensive Review ◽  
Diagnostic Challenge ◽  
Primary Case ◽  
Head Region ◽  
Head And Neck Region ◽  
Synovial Sarcomas

Synovial sarcomas are a rare entity with predilection for extremities and joints. The literature suggests that these tumours are rare in the head and neck region. Very few authors have reported their origin in head. Among the ones occurring in the head region, most of them are found to originate from the parotid area. According to our extensive review of available literature, there has been no reported case of the primary case of synovial sarcoma originating from the scalp convexity. We hereby report one such case in a young female which, by far to the best of our knowledge, is the first ever reported case of a synovial sarcoma occurring on the scalp. The tumour is also the largest ever reported in the literature and posed a great surgical and diagnostic challenge to our team. Through this paper, we recommend that synovial sarcoma should be included as a very rare yet possible differential diagnosis for the scalp tumours.

Systematic literature review of clinical outcomes in adults with metastatic or advanced synovial sarcoma

2020 ◽  
Vol 16 (35) ◽  
pp. 2997-3013
Author(s):  
Kentaro Kogushi ◽  
Michael LoPresti ◽  
Shunya Ikeda
Keyword(s):  
Synovial Sarcoma ◽  
High Frequency ◽  
Clinical Evidence ◽  
Systemic Treatment ◽  
Progression Free Survival ◽  
Treatment Modalities ◽  
Free Survival ◽  
New Treatment ◽  
Poor Outcomes

Background: Synovial sarcoma (SS) is a rare, aggressive soft tissue sarcoma with a poor prognosis after metastasis. The objective of this study was to conduct a systematic review of the clinical evidence for therapeutic options for adults with metastatic or advanced SS. Materials & methods: Relevant databases were searched with predefined keywords. Results: Thirty-nine publications reported clinical data for systemic treatment and other interventions. Data on survival outcomes varied but were generally poor (progression-free survival: 1.0–7.7 months; overall survival: 6.7–29.2 months) for adults with metastatic and advanced SS. A high frequency of neutropenia with systemic treatment and low quality of life post-progression were reported. Conclusion: Reported evidence suggests poor outcomes in adults with metastatic and advanced SS and the need for the development of new treatment modalities.

Quality of water from fish farms and histopathological analysis of tilapia ( Oreochromis sp.) in São José de Ribamar and Paço do Lumiar, state of Maranhão, Brazil

2021 ◽  
Author(s):  
Ingrid Tayane Vieira da Silva Nascimento ◽  
Natália Jovita Pereira ◽  
Raquel Soares Martins ◽  
Thiago Anchieta Melo ◽  
Débora Martins Silva Santos ◽  
...  
Keyword(s):  
Histopathological Analysis ◽  
Fish Farms ◽  
Quality Of Water

Primary renal synovial sarcoma presenting with a retroperitoneal bleed

2021 ◽  
Vol 14 (3) ◽  
pp. e237099
Author(s):  
Daanesh Huned ◽  
Juinn Huar Kam ◽  
Lui Shiong Lee ◽  
Raj Vikesh Tiwari
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Synovial Sarcoma ◽  
Soft Tissue Mass ◽  
Renal Angiomyolipoma ◽  
Right Hepatectomy ◽  
Tissue Mass ◽  
Biopsy Confirmation ◽  
Synovial Sarcomas ◽  
Neo Adjuvant Chemotherapy

Synovial sarcomas are most commonly localised in extremities, especially in the lower thigh and knee areas. Comprising less than 1% of all malignancies, retroperitoneal synovial sarcoma is very rare with primary synovial sarcoma of the kidney being even more infrequent and difficult to diagnose. We describe a case report of a renal synovial sarcoma in a young adult who was initially managed as a case of Wunderlich’s syndrome secondary to what was believed to be a ruptured renal angiomyolipoma. After biopsy confirmation, the patient was eventually managed with neo-adjuvant chemotherapy followed by a right radical nephrectomy and right hepatectomy. Despite its rarity, synovial sarcoma should be considered as differential diagnosis of a bleeding retroperitoneal soft tissue mass detected in young adults.

Effect of Sucrose on Cisplatin-induced Fatigue-like Behavior in Mice: Comparison With Fructose and Glucose

2021 ◽  
Vol 1 (2) ◽  
pp. 95-102
Author(s):  
KAZUMI YOSHIZAWA ◽  
RUKA KURONO ◽  
HARUKA SATO ◽  
ERIKA ISHIJIMA ◽  
HARUKA NASU ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Anticancer Agents ◽  
Saline Control ◽  
Common Symptom ◽  
Antitumor Effects ◽  
Patients With Cancer ◽  
Cancer Related Fatigue ◽  
Running Activity ◽  
Glucose Intake

Background/Aim: Fatigue is the most common symptom in patients with cancer undergoing radiation therapy or cancer chemotherapy. However, cancer-related fatigue remains undertreated and poorly understood. Materials and Methods: Mice were administered a single dose of cisplatin (10 mg/kg, intraperitoneally) or saline (as a control) and then treated with sucrose, fructose, glucose (each at 500 or 5,000 mg/kg, orally), or saline (control) daily for 4 days. cisplatin-induced fatigue-like behavior was investigated by assessment of running activity on a treadmill. The influence of glucose intake on tumor growth was also examined in Lewis lung carcinoma (LLC)-bearing mice. Results: Administration of sucrose and glucose improved cisplatin-induced fatigue-like behavior in mice, whereas administration of fructose showed only slight antifatigue effects. Although glucose-fed mice showed increased tumor growth, this was balanced out by the powerful cytotoxicity of cisplatin. Conclusion: Sucrose, and especially glucose, may improve patient quality of life during treatment with anticancer agents by preventing fatigue without interfering with the antitumor effects of cisplatin.

scholarly journals Combining chloroquine with RAD001 inhibits tumor growth in a NEN mouse model

2018 ◽  
Vol 25 (6) ◽  
pp. 677-686 ◽  
Author(s):  
Shani Avniel-Polak ◽  
Gil Leibowitz ◽  
Victoria Doviner ◽  
David J Gross ◽  
Simona Grozinsky-Glasberg
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Mtor Inhibitors ◽  
Degradation Pathway ◽  
Neuroendocrine Neoplasms ◽  
Histopathological Analysis ◽  
Anti Cancer ◽  
Subcutaneous Xenograft ◽  
Rheumatic Drug

Patients with neuroendocrine neoplasms (NENs) often require systemic treatment, which is frequently limited by the emergence of drug resistance. mTOR inhibitors (mTORi), such as RAD001 (everolimus), have been shown to inhibit neoplasm progression. mTORi stimulates autophagy, a degradation pathway that might promote the survival of neoplasm cells that are exposed to anti-cancer therapy. Chloroquine (CQ), a well-known anti-malarial and anti-rheumatic drug, suppresses autophagy. Based on our previous results, we hypothesized that CQ may enhance the anti-tumorigenic effects of mTORi by inhibiting autophagy and we aimed to examine the anti-tumorigenic effect of CQ, alone or in combination with RAD001. We established a NEN subcutaneous xenograft mouse model and evaluated the effect of the drugs on tumor growth, mTOR pathway, autophagy and apoptosis. CQ alone and in combination with RAD001 significantly decreased neoplasm volume. Histopathological analysis revealed that the combination of CQ and RAD001 markedly inhibited mTOR activity and neoplasm cell growth, along with accumulation of autophagosomes and increased apoptosis. In conclusion, CQ enhances the anti-tumorigenic effect of RAD001 in vivo by inhibiting autophagy. Clinical trials addressing the effects of CQ therapy on neoplasm progression in patients with NENs, mainly in those treated with mTORi, are warranted.

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