scholarly journals Genetic Reduction of Chronic Muscle Pain in Mice Lacking Calcium/Calmodulin-Stimulated Adenylyl Cyclases

2006 ◽  
Vol 2 ◽  
pp. 1744-8069-2-7 ◽  
Author(s):  
Kunjumon I Vadakkan ◽  
Hansen Wang ◽  
Shanelle W Ko ◽  
Evelyn Zastepa ◽  
Michele J Petrovic ◽  
...  
Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Der-Sheng Han ◽  
Cheng-Han Lee ◽  
Yih-Dar Shieh ◽  
Chu-Ting Chang ◽  
Min-Hsuan Li ◽  
...  

Pain ◽  
2016 ◽  
Vol 157 (2) ◽  
pp. 387-398 ◽  
Author(s):  
Rasna Sabharwal ◽  
Lynn Rasmussen ◽  
Kathleen A. Sluka ◽  
Mark W. Chapleau

2010 ◽  
Vol 30 (31) ◽  
pp. 10360-10368 ◽  
Author(s):  
W.-K. Chen ◽  
I. Y. Liu ◽  
Y.-T. Chang ◽  
Y.-C. Chen ◽  
C.-C. Chen ◽  
...  

2007 ◽  
Vol 8 (5) ◽  
pp. 422-429 ◽  
Author(s):  
Takeshi Yokoyama ◽  
Yumi Maeda ◽  
Katherine M. Audette ◽  
Kathleen A. Sluka

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e11131 ◽  
Author(s):  
James P. Lund ◽  
Somayeh Sadeghi ◽  
Tuija Athanassiadis ◽  
Nadia Caram Salas ◽  
François Auclair ◽  
...  

2013 ◽  
Vol 114 (6) ◽  
pp. 725-733 ◽  
Author(s):  
Kathleen A. Sluka ◽  
James M. O'Donnell ◽  
Jessica Danielson ◽  
Lynn A. Rasmussen

Chronic musculoskeletal pain is a significant health problem and is associated with increases in pain during acute physical activity. Regular physical activity is protective against many chronic diseases; however, it is unknown if it plays a role in development of chronic pain. The current study induced physical activity by placing running wheels in home cages of mice for 5 days or 8 wk and compared these to sedentary mice without running wheels in their home cages. Chronic muscle pain was induced by repeated intramuscular injection of pH 4.0 saline, exercise-enhanced pain was induced by combining a 2-h fatiguing exercise task with a low-dose muscle inflammation (0.03% carrageenan), and acute muscle inflammation was induced by 3% carrageenan. We tested the responses of the paw (response frequency) and muscle (withdrawal threshold) to nociceptive stimuli. Because the rostral ventromedial medulla (RVM) is involved in exercise-induced analgesia and chronic muscle pain, we tested for changes in phosphorylation of the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor in the RVM. We demonstrate that regular physical activity prevents the development of chronic muscle pain and exercise-induced muscle pain by reducing phosphorylation of the NR1 subunit of the NMDA receptor in the central nervous system. However, regular physical activity has no effect on development of acute pain. Thus physical inactivity is a risk factor for development of chronic pain and may set the nervous system to respond in an exaggerated way to low-intensity muscle insults.


2009 ◽  
Vol 29 (2) ◽  
pp. 115-118
Author(s):  
Junichiro TAMAKI ◽  
Masayoshi TSURUOKA ◽  
Dan WANG ◽  
Masako MAEDA ◽  
Bunsho HAYASHI ◽  
...  

2019 ◽  
Vol 46 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Birgitte Ahlsen ◽  
Eivind Engebretsen ◽  
David Nicholls ◽  
Anne Marit Mengshoel

A patient-centred approach has gained increasing interest in medicine and other health sciences. Whereas there are discussions about the meaning of a patient-centred approach and what the concept entails, little is known about how the patient as a person is understood in patient-centred care. This article investigates understandings of the patient as a self in patient-centred care through physiotherapy of patients with chronic muscle pain. The material consists of interviews with five Norwegian physiotherapists working in a rehabilitation clinic. Drawing on Kristeva’s discussion of subjectivity in medical discourse, the study highlights two different treatment storylines that were closely entwined. One storyline focuses on open singular healing processes in which the treatment was based on openness to a search for meaning and sharing. In this storyline, the “person“ at the centre of care was not essentialised in terms of biological mechanisms, but rather considered as a vulnerable, irrational and moving self. By contrast, the second storyline focused on goal-oriented interventions aimed at restoring the patient to health. Here, the person in the centre of the treatment was shaped according to model narratives about “the successful patient”; the empowered, rational, choosing and self-managing individual. As such, the findings revealed two conflicting concepts of the individual patient inherent in patient-centred care. On the one hand, the patient is seen as being a person in constant movement, and on the other, they are captured by more standardised terms designed to focus on a more stable notion of outcome of illness. Therefore, our study suggests that the therapists’ will to recognise the individual in patient-centred care had a counterpart involving a marginalisation of the singular.


Sign in / Sign up

Export Citation Format

Share Document