chronic muscle pain
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2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Geun Joo Choi ◽  
Hyun Kang ◽  
Oh Haeng Lee ◽  
Eun Jin Ahn ◽  
Fletcher A. White ◽  
...  

Abstract Background Rubus occidentalis, also known as black raspberry, contains several bioactive components that vary depending on the maturity of the fruit. The goal of this study was to evaluate the efficacy of immature Rubus occidentalis extract(iROE) on acid-induced hyperalgesia, investigate the mechanism involved, and compare the antihyperalgesic effect of immature and mature ROEs. Methods In adult male Sprague-Dawley rats, chronic muscle pain was induced via two injections of acidic saline into one gastrocnemius muscle. To evaluate the dose response, the rats were injected intraperitoneally with 0.9% saline or iROE (10, 30, 100, or 300 mg/kg) following hyperalgesia development. To evaluate the mechanism underlying iROE-induced analgesia, the rats were injected intraperitoneally with saline, yohimbine 2 mg/kg, dexmedetomidine 50 μg/kg, prazosin 1 mg/kg, atropine 5 mg/kg, mecamylamine 1 mg/kg, or naloxone 5 mg/kg 24 h after hyperalgesia development, followed by iROE 300 mg/kg administration. To compare immature versus mature ROE, the rats were injected with mature ROE 300 mg/kg and immature ROE 300 mg/kg after hyperalgesia development. For all experiments, the mechanical withdrawal threshold(MWT) was evaluated using von Frey filaments before the first acidic saline injection, 24 h after the second injection, and at various time points after drug administration. Data were analysed using multivariate analysis of variance(MANOVA) and the linear mixed-effects model(LMEM). We compared the MWT at each time point using analysis of variance with the Bonferroni correction. Results The iROE 300 mg/kg injection resulted in a significant increase in MWT compared with the control, iROE 30 mg/kg, and iROE 100 mg/kg injections at ipsilateral and contralateral sites. The iROE injection together with yohimbine, mecamylamine, or naloxone significantly decreased the MWT compared with iROE alone, whereas ROE together with dexmedetomidine significantly increased the MWT. According to MANOVA, the effects of immature and mature ROEs were not significantly different; however, the LMEM presented a significant difference between the two groups. Conclusions Immature R. occidentalis showed antihyperalgesic activity against acid-induced chronic muscle pain, which may be mediated by the α2-adrenergic, nicotinic cholinergic, and opioid receptors. The iROE displayed superior tendency regarding analgesic effect compared to mature ROE.


2021 ◽  
Vol 29 (1) ◽  
Author(s):  
Monavar Hadizadeh ◽  
Abbas Rahimi ◽  
Mohammad Javaherian ◽  
Meysam Velayati ◽  
Jan Dommerholt

Abstract Introduction Myofascial pain syndrome (MPS) is one of the most common disorders causing chronic muscle pain. Almost one-third of patients with musculoskeletal complaints meet the MPS criteria. The aim of this study is to evaluate the effectiveness of intramuscular electrical stimulation (IMES) in patients with MPS through a systematic review method. Methods PubMed, Scopus, Embase, ProQuest, PEDro, Web of Science, and CINAHL were systematically searched to find out the eligible articles without language limitations from 1990 to December 30, 2020. All relevant randomized controlled trials that compared the effectiveness of IMES with sham-IMES, dry needling, or exercise therapy in patients with MPS were included. Full texts of the selected studies were critically appraised using Revised Cochrane risk-of-bias tool for randomized trials (RoB2). Results Six studies (out of 397) had met our inclusion criteria (involving 158 patients) and were entered to the systematic review. Outcome measures examined in these studies included pain, range of motion, pressure pain threshold, biochemical factors, disability, and amount of analgesic use. In the most studies, it has been shown that IMES is more effective than the control group in improving some outcome measurements such as pain. Conclusion There is preliminary evidence from a few small trials suggesting the efficacy of IMES for the care of myofascial pain syndrome. The data support the conduct of larger trials investigating the efficacy of IMES.


Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Der-Sheng Han ◽  
Cheng-Han Lee ◽  
Yih-Dar Shieh ◽  
Chu-Ting Chang ◽  
Min-Hsuan Li ◽  
...  

Author(s):  
Łukasz Radzimiński ◽  
Zbigniew Jastrzębski ◽  
Guillermo F. López-Sánchez ◽  
Andrzej Szwarc ◽  
Henryk Duda ◽  
...  

The main purpose of this study is to assess the relations between training loads and selected blood parameters in professional soccer players during a preseason sports camp. Fifteen professional soccer players (age: 24.3 ± 5.25 year; height: 182.6 ± 6.75 cm; weight: 76.4 ± 6.72 kg) participated in the 12-day training camp. All the training sessions and friendly games were accurately analyzed with a GPS system. Blood samples were taken from the players and analyzed before the camp (PRE), in the middle (MID), and one day after the camp (POST). Mean total distance covered by the players during the camp was 85,205 ± 2685 m, high-intensity running 12,454 ± 1873 m, and sprinting 639 ± 219 m. The highest aspartate transaminase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), and C-reactive protein (CRP) values were observed after six days of the camp. The application of intensive training during a 12-day sports camp can be associated with chronic muscle pain with high activity of some blood enzymes (CK, AST) and a high concentration of myoglobin (Mb). During training camps longer than 10 days, it would be necessary to apply, every second or third day, one day of rest, and the training load should not exceed two units every day.


2020 ◽  
Vol 16 (3) ◽  
pp. 403-414
Author(s):  
Carolina Ocanha Jorge ◽  
Graciana de Azambuja ◽  
Beatriz Botasso Gomes ◽  
Hayla Lourenço Rodrigues ◽  
Augusto Ducati Luchessi ◽  
...  

2020 ◽  
Vol 99 (9) ◽  
pp. 1004-1012
Author(s):  
M.K. Chung ◽  
S. Wang ◽  
J. Yang ◽  
I. Alshanqiti ◽  
F. Wei ◽  
...  

Craniofacial muscle pain is highly prevalent in temporomandibular disorders but is difficult to treat. Enhanced understanding of neurobiology unique to craniofacial muscle pain should lead to the development of novel mechanism-based treatments. Herein, we review recent studies to summarize neural pathways of craniofacial muscle pain. Nociceptive afferents in craniofacial muscles are predominantly peptidergic afferents enriched with TRPV1. Signals from peripheral glutamate receptors converge onto TRPV1, leading to mechanical hyperalgesia. Further studies are needed to clarify whether hyperalgesic priming in nonpeptidergic afferents or repeated acid injections also affect craniofacial muscle pain. Within trigeminal ganglia, afferents innervating craniofacial muscles interact with surrounding satellite glia, which enhances the sensitivity of the inflamed neurons as well as nearby uninjured afferents, resulting in hyperalgesia and ectopic pain originating from adjacent orofacial tissues. Craniofacial muscle afferents project to a wide area within the trigeminal nucleus complex, and central sensitization of medullary dorsal horn neurons is a critical factor in muscle hyperalgesia related to ectopic pain and emotional stress. Second-order neurons project rostrally to pathways associated with affective pain, such as parabrachial nucleus and medial thalamic nucleus, as well as sensory-discriminative pain, such as ventral posteromedial thalamic nuclei. Abnormal endogenous pain modulation can also contribute to chronic muscle pain. Descending serotonergic circuits from the rostral ventromedial medulla facilitate activation of second-order neurons in the trigeminal nucleus complex, which leads to the maintenance of mechanical hyperalgesia of inflamed masseter muscle. Patients with temporomandibular disorders exhibit altered brain networks in widespread cortical and subcortical regions. Recent development of methods for neural circuit manipulation allows silencing of specific hyperactive neural circuits. Chemogenetic silencing of TRPV1-expressing afferents or rostral ventromedial medulla neurons attenuates hyperalgesia during masseter inflammation. It is likely, therefore, that further delineation of neural circuits mediating craniofacial muscle hyperalgesia potentially enhances treatment of chronic muscle pain conditions.


2019 ◽  
Vol 13 ◽  
Author(s):  
Chu-Ting Chang ◽  
Sitt Wai Fong ◽  
Cheng-Han Lee ◽  
Yu-Chia Chuang ◽  
Shing-Hong Lin ◽  
...  

2019 ◽  
Vol 46 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Birgitte Ahlsen ◽  
Eivind Engebretsen ◽  
David Nicholls ◽  
Anne Marit Mengshoel

A patient-centred approach has gained increasing interest in medicine and other health sciences. Whereas there are discussions about the meaning of a patient-centred approach and what the concept entails, little is known about how the patient as a person is understood in patient-centred care. This article investigates understandings of the patient as a self in patient-centred care through physiotherapy of patients with chronic muscle pain. The material consists of interviews with five Norwegian physiotherapists working in a rehabilitation clinic. Drawing on Kristeva’s discussion of subjectivity in medical discourse, the study highlights two different treatment storylines that were closely entwined. One storyline focuses on open singular healing processes in which the treatment was based on openness to a search for meaning and sharing. In this storyline, the “person“ at the centre of care was not essentialised in terms of biological mechanisms, but rather considered as a vulnerable, irrational and moving self. By contrast, the second storyline focused on goal-oriented interventions aimed at restoring the patient to health. Here, the person in the centre of the treatment was shaped according to model narratives about “the successful patient”; the empowered, rational, choosing and self-managing individual. As such, the findings revealed two conflicting concepts of the individual patient inherent in patient-centred care. On the one hand, the patient is seen as being a person in constant movement, and on the other, they are captured by more standardised terms designed to focus on a more stable notion of outcome of illness. Therefore, our study suggests that the therapists’ will to recognise the individual in patient-centred care had a counterpart involving a marginalisation of the singular.


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