scholarly journals Protocol for the adolescent hayfever trial: cluster randomised controlled trial of an educational intervention for healthcare professionals for the management of school-age children with hayfever

Trials ◽  
2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Victoria S Hammersley ◽  
Samantha Walker ◽  
Rob Elton ◽  
Aziz Sheikh
Keyword(s):  
Randomised Controlled Trial ◽  
Educational Intervention ◽  
Healthcare Professionals ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
School Age Children ◽  
School Age ◽  
Cluster Randomised ◽  
Randomised Controlled

scholarly journals A cluster-randomised controlled trial comparing school and community-based deworming for soil transmitted helminth control in school-age children: the CoDe-STH trial protocol

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Naomi E. Clarke ◽  
Dinh Ng-Nguyen ◽  
Rebecca J. Traub ◽  
Archie C. A. Clements ◽  
Kate Halton ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Primary Schools ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
Trial Registration ◽  
School Age Children ◽  
School Age ◽  
School Based ◽  
Cluster Randomised ◽  
Randomised Controlled

Abstract Background Current guidelines and targets for soil-transmitted helminth (STH) control focus on school-based deworming for school-age children, given the high risk of associated morbidity in this age group. However, expanding deworming to all age groups may achieve improved STH control among both the community in general and school-age children, by reducing their risk of reinfection. This trial aims to compare school-based targeted deworming with community-wide mass deworming in terms of impact on STH infections among school-age children. Methods The CoDe-STH (Community Deworming against STH) trial is a cluster-randomised controlled trial (RCT) in 64 primary schools in Dak Lak province, Vietnam. The control arm will receive one round of school-based targeted deworming with albendazole, while in the intervention arm, community-wide mass deworming with albendazole will be implemented alongside school-based deworming. Prevalence of STH infections will be measured in school-age children at baseline and 12 months following deworming. The primary outcome is hookworm prevalence in school-age children at 12 months, by quantitative PCR. Analysis will be intention-to-treat, with outcomes compared between study arms using generalised linear and non-linear mixed models. Additionally, cost-effectiveness of mass and targeted deworming will be calculated and compared, and focus group discussions and interviews will be used to assess acceptability and feasibility of deworming approaches. Individual based stochastic models will be used to predict the impact of mass and targeted deworming strategies beyond the RCT timeframe to assess the likelihood of parasite population ‘bounce-back’ if deworming is ceased due to low STH prevalence. Discussion The first large-scale trial comparing mass and targeted deworming for STH control in South East Asia will provide key information for policy makers regarding the optimal design of STH control programs. Trial registration ACTRN12619000309189.

scholarly journals Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention

2020 ◽  
Vol 70 (699) ◽  
pp. e684-e695
Author(s):  
Rick T van Uum ◽  
Roderick P Venekamp ◽  
Nicolaas PA Zuithoff ◽  
Alies Sjoukes ◽  
Alma C van de Pol ◽  
...  
Keyword(s):  
Pain Management ◽  
Randomised Controlled Trial ◽  
Educational Intervention ◽  
Controlled Trial ◽  
Acute Otitis Media ◽  
Intervention Group ◽  
Cluster Randomised Controlled Trial ◽  
Cluster Randomised ◽  
Randomised Controlled ◽  
Analgesic Use

BackgroundPain management in acute otitis media (AOM) is often suboptimal, potentially leading to unnecessary discomfort, GP reconsultation, and antibiotic prescribing.AimTo assess the effectiveness of a GP-targeted educational intervention to improve pain management in children with AOM.Design and settingPragmatic, cluster randomised controlled trial (RCT). GPs in 37 practices (intervention n = 19; control n = 18) across the Netherlands recruited 224 children with GP-confirmed AOM and ear pain (intervention n = 94; control n = 130) between February 2015 and May 2018.MethodGPs in practices allocated to the intervention group were trained (online and face-to-face) to discuss pain management with parents using an information leaflet, and prompted to prescribe weight-appropriate dosed paracetamol. Ibuprofen was additionally prescribed if pain control was still insufficient. GPs in the control group provided usual care.ResultsMean ear pain scores over the first 3 days were similar between groups (4.66 versus 4.36; adjusted mean difference = −0.05; 95% confidence intervals [CI] = −0.93 to 0.83), whereas analgesic use, in particular ibuprofen, was higher in the intervention group. The total number of antibiotic prescriptions during the 28-day follow-up was similar (mean rate 0.43 versus 0.47; adjusted rate ratio [aRR] 0.97; 95% CI = 0.68 to 1.38). Parents of children in the intervention group were more likely to reconsult for AOM-related complaints (mean rate 0.70 versus 0.41; aRR 1.73; 95% CI = 1.14 to 2.62).ConclusionAn intervention aimed at improving pain management for AOM increases analgesic use, particularly ibuprofen, but does not provide symptomatic benefit. GPs are advised to carefully weigh the potential benefits of ibuprofen against its possible harms.

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