Relationship between insulin administration and substrates oxidation during continuous aerobic exercise in adolescents with type 1 diabetes mellitus

Aims Elevated sex hormone-binding globulin (SHBG) concentrations have been described in patients with type 1 diabetes mellitus (T1DM), probably due to low portal insulin concentrations. We aimed to investigate whether the route of insulin administration, continuous intraperitoneal insulin infusion (CIPII), or subcutaneous (SC), influences SHBG concentrations among T1DM patients. Methods Post hoc analysis of SHBG in samples derived from a randomized, open-labeled crossover trial was carried out in 20 T1DM patients: 50% males, mean age 43 (±13) years, diabetes duration 23 (±11) years, and hemoglobin A1c (HbA1c) 8.7 (±1.1) (72 (±12) mmol/mol). As secondary outcomes, testosterone, 17-β-estradiol, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were analyzed. Results Estimated mean change in SHBG was −10.3nmol/L (95% CI: −17.4, −3.2) during CIPII and 3.7nmol/L (95% CI: −12.0, 4.6) during SC insulin treatment. Taking the effect of treatment order into account, the difference in SHBG between therapies was −6.6nmol/L (95% CI: −17.5, 4.3); −12.7nmol/L (95% CI: −25.1, −0.4) for males and −1.7nmol/L (95% CI: −24.6, 21.1) for females, respectively. Among males, SHBG and testosterone concentrations changed significantly during CIPII; −15.8nmol/L (95% CI: −24.2, −7.5) and −8.3nmol/L (95% CI: −14.4, −2.2), respectively. The difference between CIPII and SC insulin treatment was also significant for change in FSH 1.2U/L (95% CI: 0.1, 2.2) among males. Conclusions SHBG concentrations decreased significantly during CIPII treatment. Moreover, the difference in change between CIPII and SC insulin therapy was significant for SHBG and FSH among males. These findings support the hypothesis that portal insulin administration influences circulating SHBG and sex steroids.

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A model of poorly controlled type 1 diabetes mellitus and its treatment with aerobic exercise training

Diabetes & Metabolism ◽

10.1016/j.diabet.2013.02.004 ◽

2013 ◽

Vol 39 (3) ◽

pp. 226-235 ◽

Cited By ~ 18

Author(s):

C.W.J. Melling ◽

K.N. Grisé ◽

C.P. Hasilo ◽

B. Fier ◽

K.J. Milne ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Exercise Training ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Aerobic Exercise Training

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Differences in plasma apelin and visfatin levels between patients with type 1 diabetes mellitus and healthy subjects and response after acute hyperglycemia and insulin administration

HORMONES ◽

10.14310/horm.2002.1376 ◽

2012 ◽

Vol 11 (4) ◽

pp. 444-450 ◽

Cited By ~ 9

Author(s):

Kleopatra Alexiadou ◽

Alexander Kokkinos ◽

Stavros Liatis ◽

Despoina Perrea ◽

Nicholas Katsilambros ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Healthy Subjects ◽

Insulin Administration ◽

Acute Hyperglycemia ◽

Plasma Apelin

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Differences in parental involvement in the care of children and adolescents with type 1 diabetes mellitus on multiple daily insulin injections versus continuous subcutaneous insulin infusion

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2015-0030 ◽

2016 ◽

Vol 29 (3) ◽

Cited By ~ 1

Author(s):

Ayse Pinar Cemeroglu ◽

Scott Timmer ◽

Zaahir Turfe ◽

Alan T. Davis ◽

Tracy J. Koehler ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Parental Involvement ◽

Type 1 Diabetes Mellitus ◽

Diabetes Care ◽

Continuous Subcutaneous Insulin Infusion ◽

Insulin Infusion ◽

Subcutaneous Insulin ◽

Insulin Administration

AbstractAssessing the degree of involvement of caregivers for children with type 1 diabetes mellitus (T1DM) in their diabetes care, differences in the degree of involvement based on the method of insulin administration (multiple daily injections: MDI/continuous subcutaneous insulin infusion: CSII), and its effect on glycemic control.: This was a cross-sectional study with T1DM patients, ages 6–13 years using a six question survey derived from the Diabetes Family Responsibility Questionnaire (DFRQ). All caregivers (n=140) and participants between ages 11 and 13 (n=60) completed the survey.Significant differences between MDI and CSII caregiver responses were found for responsibility for giving insulin boluses, as well as for rotation of infusion/injection sites (p<0.001 and p=0.03, respectively). A sub-analysis of caregiver responses for caregiver versus child responsibility for giving infusion boluses (excluding shared responsibility) showed that 36% of children in the CSII group had primary responsibility for giving insulin boluses, compared to 17% in the MDI group (p<0.001). The median agreement for all questions combined between participants and caregivers for ages 11–13 (n=60 pairs) was “poor” (κ=0.18). No significant effect of parental involvement on last 2-year average HbACaregiver reported diabetes care responsibility (mostly parent, mostly child, shared between parent and child) varies for certain aspects of diabetes related care for children ages 6–13, depending upon the mode of insulin administration. Based on the reported degree of parental collaboration, HbA

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Effects of a home-based aerobic exercise programme in children with type 1 diabetes mellitus

Journal of Clinical Nursing ◽

10.1111/j.1365-2702.2010.03533.x ◽

2011 ◽

Vol 20 (5-6) ◽

pp. 681-691 ◽

Cited By ~ 14

Author(s):

Ching-Hsiang Wong ◽

Yi-Chien Chiang ◽

Jackson Pui Man Wai ◽

Fu-Sung Lo ◽

Chao-Hsing Yeh ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Exercise Programme ◽

Home Based

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Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs.061302 ◽

2019 ◽

Vol 6 (13) ◽

pp. 331-345 ◽

Cited By ~ 2

Author(s):

Mayane Oliveira Rebouças da Silveira ◽

Liliany Souza de Brito Amaral ◽

Samira Itana de Souza ◽

Halanna Rocha Ferraz ◽

Jéssica Alves Dias ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Renal Function ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Diabetic Rats ◽

Ovariectomized Rats ◽

And Oxidative Stress

This study evaluated the aerobic exercise effects of moderate and progressive intensity on renal function and structure, and oxidative stress in ovariectomized rats with type 1 diabetes mellitus induced by streptozotocin (STZ). Eighteen Wistar rats were divided into 3 groups: OSC - ovariectomized and sedentary control rats; OSD - ovariectomized and sedentary diabetic rats; and OTD - ovariectomized and trained diabetic rats. After induction of diabetes, the OTD group was submitted to eight weeks of exercise. Twenty-four hours after the last training session urine samples were collected. Blood samples and kidneys were collected after euthanasia for renal function analysis, histology, morphometry and oxidative stress. Our results have shown a reduction of the weight gain, increase of kidney weight and postprandial glycemia in diabetic rats. However, exercise decreased glycosuria and prevented the proteinuria in OTD group rats. Focal segmental glomerulosclerosis (FSGS), juxtamedullary glomerular tuft area, tubulointerstitial lesions (TIL), brush border loss and tubular cell debridement were reduced in OTD rats. In addition, exercise training decreased urinary and plasma concentrations of thiobarbituric acid reactive substance (TBARS). Our results demonstrate the beneficial effect of progressive aerobic exercise on proteinuria, glycosuria, and renal structure in ovariectomized diabetic rats, which may be mediated in part by reduction of oxidative stress.

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