Association of dietary fat composition with kidney function decline in patients with type 2 diabetes

Abstract Context While inflammation has been associated with kidney function in long-standing diabetes, its possible association in newly diagnosed diabetes is unknown. Objective To investigate cross-sectional and prospective associations between biomarkers of inflammation and kidney function in recent-onset diabetes. Methods The study included individuals with type 1 and type 2 diabetes with known diabetes duration of <1 year from the German Diabetes Study. Baseline serum concentrations of 74 biomarkers were measured using proximity extension assay technology and their associations with estimated glomerular filtration rate (eGFR) and kidney function decline over 5 years were tested using multiple linear and logistic regression analysis. Results The cross-sectional analysis included 165 individuals with type 1 diabetes and 291 with type 2 diabetes. Baseline eGFR was higher in type 1 compared with type 2 diabetes (102 ± 15 vs 90 ± 16 mL/min/1.73 m2; P < 0.0001). After full adjustment for covariates and multiple testing, 7 biomarkers were associated with lower baseline eGFR in type 1 diabetes and 24 were associated with lower baseline eGFR in type 2 diabetes. Among these biomarkers, 6 biomarkers (CD5, CCL23, CST5, IL-10RB, PD-L1, TNFRSF9) were inversely associated with eGFR in both diabetes types. The prospective analysis did not detect associations between inflammatory biomarkers and kidney function decline. No evidence of an interaction between diabetes type and inflammatory biomarkers was found. Conclusion Several biomarkers of inflammation associate with lower baseline eGFR in recent-onset type 1 and type 2 diabetes, but do not associate with kidney function loss during the first 5 years after the diagnosis of diabetes.

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FP518PROGRESSIVE KIDNEY FUNCTION DECLINE: THE PARADIGM OF BIOPSY-PROVEN DIABETIC KIDNEY DISEASE IN A CHINESE COHORT WITH TYPE 2 DIABETES

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz106.fp518 ◽

2019 ◽

Vol 34 (Supplement_1) ◽

Author(s):

Yiting Wang

Keyword(s):

Type 2 Diabetes ◽

Kidney Disease ◽

Kidney Function ◽

Diabetic Kidney Disease ◽

Diabetic Kidney ◽

Chinese Cohort ◽

Kidney Function Decline

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Rate of Decline in Kidney Function and Age-of-Onset or Duration of Type 2 Diabetes

10.21203/rs.3.rs-289704/v1 ◽

2021 ◽

Author(s):

Oyunchimeg Buyadaa ◽

Agus Salim ◽

Jedidiah I Morton ◽

Dianna J Magliano ◽

Jonathan E Shaw

Keyword(s):

Type 2 Diabetes ◽

Kidney Function ◽

Estimated Glomerular Filtration Rate ◽

Middle Age ◽

Age Of Onset ◽

Duration Of Diabetes ◽

Rate Of Decline ◽

Kidney Function Decline ◽

Egfr Decline

Abstract The association between rate of kidney function decline and age-of-onset or duration of type 2 diabetes has not been well investigated. We aimed to examine whether rates of estimated glomerular filtration rate (eGFR) decline differ by age-of-onset or duration in people with type 2 diabetes. Using the Action to Control Cardiovascular Risk in Diabetes study dataset rates of eGFR decline were calculated using a joint-longitudinal-survival model and were compared among groups defined by the age-of-onset (0–39, 40–49, 50–59, 60–69 and > 70 years) and 5-year diabetes duration intervals. Changes in renal function were evaluated using median of 6 (interquartile range: 3–10) eGFR measurements per person. eGFR decline was the slowest in those with an age-at-diagnosis of 50 − 59 years or those with duration of diabetes < 5 years. The rates of eGFR decline were significantly greater in those with an age-of-onset < 40 years or those with duration of diabetes > 20 years compared to those diagnosed at 50 − 59 or those with duration of diabetes < 5 years (-1.98 vs -1.61 ml/min/year; -1.82 vs -1.52 ml/min/year; respectively (p < 0.001). Those with youngest age-of-onset or longest duration of type 2 diabetes had more rapid declines in eGFR compared to those diagnosed at middle age or those with shorter duration of diabetes.

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