scholarly journals N-acetylcysteine (NAC) decreases liver lactate levels in septic shock patients shown by magnetic resonance spectroscopy

Critical Care ◽  
10.1186/cc73 ◽  
1997 ◽  
Vol 1 (Suppl 1) ◽  
pp. P084
Author(s):  
C Spies ◽  
A Schilling ◽  
JO Heidenreich ◽  
R Öhring ◽  
C Brodel ◽  
...  
Keyword(s):  
Septic Shock ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Lactate Levels

scholarly journals Magnetic resonance spectroscopy of atypical diffuse pontine masses

2003 ◽  
Vol 15 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Mark D. Krieger ◽  
Stefan Blüml ◽  
J. Gordon McComb
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mr Imaging ◽  
Resonance Spectroscopy ◽  
Prognostic Information ◽  
Original Diagnosis ◽  
Dismal Prognosis ◽  
Diffuse Pontine Glioma ◽  
Lactate Levels ◽  
Elevated Lipid

Object Diffuse pontine gliomas in children carry a dismal prognosis, with a mean survival of less than 1 year despite therapy. The diagnosis is based on the characteristic changes demonstrated on traditional magnetic resonance (MR) imaging. A few typically MR imaging–appearing pontine masses, however, do not behave in the expected fashion, which calls the original diagnosis into question. Methods The authors conducted a retrospective review of data obtained in 42 children (age 6 months–13 years) in whom diffuse pontine glioma had been diagnosed at their institution. Five of these patients (12%) survived longer than expected (> 8 months). There were no differences in these patients in terms of demographics, presentation, traditional imaging findings, or treatment compared with the group as a whole. Magnetic resonance spectroscopy, however, demonstrated two distinct patterns not seen in typical diffuse pontine gliomas. In two patients elevated lipid and lactate levels were shown, with decreased levels of choline, myoinositol, and n-acetyl-aspartate (NAA). In the other patients strikingly elevated choline/creatinine ratios and myoinositol levels were observed in comparison with typical pontine tumors. Conclusions These MR spectroscopy patterns demonstrated in this retrospective study seem to convey prognostic information and may lead to an expansion of this diagnostic tool.

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