scholarly journals Genome-wide association study reveals novel loci for litter size and its variability in a Large White pig population

BMC Genomics ◽  
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
E. Sell-Kubiak ◽  
N. Duijvesteijn ◽  
M. S. Lopes ◽  
L. L. G. Janss ◽  
E. F. Knol ◽  
...  
Keyword(s):  
Association Study ◽  
Litter Size ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Large White ◽  
Genome Wide ◽  
Large White Pig

scholarly journals Genome-wide association study for reproductive traits in a Large White pig population

2018 ◽  
Vol 49 (2) ◽  
pp. 127-131 ◽  
Author(s):  
Y. Wang ◽  
X. Ding ◽  
Z. Tan ◽  
K. Xing ◽  
T. Yang ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Reproductive Traits ◽  
Genome Wide Association ◽  
Large White ◽  
Genome Wide ◽  
Large White Pig

A genome‐wide association study reveals additive and dominance effects on growth and fatness traits in large white pigs

2021 ◽  
Vol 52 (5) ◽  
pp. 749-753
Author(s):  
W. Yang ◽  
J. Wu ◽  
J. Yu ◽  
X. Zheng ◽  
H. Kang ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Large White ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 732 ◽  
Author(s):  
Zhang ◽  
Chen ◽  
Ye ◽  
He ◽  
Huang ◽  
...  
Keyword(s):  
Association Study ◽  
Candidate Genes ◽  
Litter Size ◽  
Production Efficiency ◽  
Genome Wide Association Study ◽  
Reproductive Traits ◽  
Genome Wide Association ◽  
Litter Weight ◽  
Genome Wide ◽  
A Genome

In the pig industry, reproductive traits constantly influence the production efficiency. To identify markers and candidate genes underlying porcine reproductive traits, a genome-wide association study (GWAS) was performed in a Duroc pig population. In total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, and four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. The results showed that 20 potential SNPs reached the level of suggestive significance and were associated with these traits of interest. Several important candidate genes, including TXN2, KCNA1, ENSSSCG00000003546, ZDHHC18, MAP2K6, BICC1, FAM135B, EPHB2, SEMA4D, ST3GAL1, KCTD3, FAM110A, TMEM132D, TBX3, and FAM110A, were identified and might compose the underlying genetic architecture of porcine reproductive traits. These findings help to understand the genetic basis of porcine reproductive traits and provide important information for molecular breeding in pigs.

scholarly journals Genome-wide identification of a regulatory mutation in BMP15 controlling prolificacy in sheep

2019 ◽  
Author(s):  
Louise Chantepie ◽  
Loys Bodin ◽  
Julien Sarry ◽  
Florent Woloszyn ◽  
Florence Plisson-Petit ◽  
...  
Keyword(s):  
Association Study ◽  
Litter Size ◽  
X Chromosome ◽  
Genome Wide Association Study ◽  
Ovulation Rate ◽  
Genome Wide Association ◽  
Heterozygous State ◽  
Sheep Population ◽  
Massif Central ◽  
Genome Wide

AbstractThe search for the genetic determinism of prolificacy variability in sheep has evidenced several major mutations in genes playing a crucial role in the control of ovulation rate. In the Noire du Velay (NV) sheep population, a recent genetic study has evidenced the segregation of such a mutation named FecLL. However, based on litter size (LS) records of FecLL non-carrier ewes, the segregation of a second prolificacy major mutation was suspected in this population. In order to identify this mutation, we have combined case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing and functional analyses. A new single nucleotide polymorphism (OARX:50977717T>A, NC_019484) located on the X chromosome upstream of the BMP15 gene was evidenced highly associated with the prolificacy variability (P =1.93E-11). The variant allele was called FecXN and shown to segregate also in the Blanche du Massif Central (BMC) sheep population. In both NV and BMC, the FecXN allele frequency was estimated close to 0.10, and its effect on LS was estimated at +0.20 lamb per lambing at heterozygous state. Homozygous FecXN carrier ewes were fertile with increased prolificacy in contrast to numerous mutations affecting BMP15. At the molecular level, FecXN was shown to decrease BMP15 promoter activity and to impact BMP15 expression in oocyte. This regulatory action was proposed as the causal mechanism for the FecXN mutation to control ovulation rate and prolificacy in sheep.Author SummaryIn the genetic etiology of women infertility syndromes, a focus was done on the oocyte-expressed BMP15 and GDF9 genes harboring several mutations associated with ovarian dysfunctions. In sheep also, mutations in these two genes are known to affect the ovarian function leading to sterility or, on the opposite, increasing ovulation rate and litter size constituting the prolificacy trait genetically selected in this species. Through a genome-wide association study with the prolificacy phenotype conducted in the French Noire du Velay sheep breed, we describe a novel mutation located in the regulatory region upstream of the BMP15 gene on the X chromosome. This mutation increases litter size by +0.2 lamb per lambing at the heterozygous state, possibly through an inhibition of BMP15 expression within the oocyte. Our findings suggest a novel kind of BMP15 variant responsible for high prolificacy, in contrast to all other BMP15 variants described so far in the coding sequence.

scholarly journals Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 434
Author(s):  
Wilber Hernández-Montiel ◽  
Mario Alberto Martínez-Núñez ◽  
Julio Porfirio Ramón-Ugalde ◽  
Sergio Iván Román-Ponce ◽  
Rene Calderón-Chagoya ◽  
...  
Keyword(s):  
Association Study ◽  
Candidate Genes ◽  
Litter Size ◽  
Genome Wide Association Study ◽  
Transforming Growth Factor ◽  
Genome Wide Association ◽  
Reproductive Process ◽  
Genome Wide ◽  
Pelibuey Sheep ◽  
A Genome

The Pelibuey sheep has adaptability to climatic variations, resistance to parasites, and good maternal ability, whereas some ewes present multiple births, which increases the litter size in farm sheep. The litter size in some wool sheep breeds is associated with the presence of mutations, mainly in the family of the transforming growth factor β (TGF-β) genes. To explore genetic mechanisms underlying the variation in litter size, we conducted a genome-wide association study in two groups of Pelibuey sheep (multiparous sheep with two lambs per birth vs. uniparous sheep with a single lamb at birth) using the OvineSNP50 BeadChip. We identified a total of 57 putative SNPs markers (p < 3.0 × 10−3, Bonferroni correction). The candidate genes that may be associated with litter size in Pelibuey sheep are CLSTN2, MTMR2, DLG1, CGA, ABCG5, TRPM6, and HTR1E. Genomic regions were also identified that contain three quantitative trait loci (QTLs) for aseasonal reproduction (ASREP), milk yield (MY), and body weight (BW). These results allowed us to identify SNPs associated with genes that could be involved in the reproductive process related to prolificacy.

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