scholarly journals Role of dexamethasone in the para-vertebral block for pediatric patients undergoing aortic coarctation repair. randomized, double-blinded controlled study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Amany H. Saleh ◽  
Passaint F. Hassan ◽  
Mohamed Elayashy ◽  
Hamza M. Hamza ◽  
Mona H. Abdelhamid ◽  
...  
Keyword(s):  
Aortic Coarctation ◽  
Pediatric Patients ◽  
Controlled Study ◽  
Coarctation Repair ◽  
Double Blinded

Impact of Obesity on Left Ventricular Geometry and Function in Pediatric Patients after Successful Aortic Coarctation Repair

2011 ◽  
Vol 28 (8) ◽  
pp. 907-912 ◽  
Author(s):  
Giovanni Di Salvo ◽  
Simona Gala ◽  
Biagio Castaldi ◽  
Luca Baldini ◽  
Giuseppe Limongelli ◽  
...  
Keyword(s):  
Aortic Coarctation ◽  
Pediatric Patients ◽  
Left Ventricular ◽  
Left Ventricular Geometry ◽  
Ventricular Geometry ◽  
Coarctation Repair ◽  
And Function

scholarly journals Application of intravenous lidocaine in patients undergoing operative hysteroscopy: a randomized, double-blind, controlled study

2019 ◽  
Author(s):  
Huaxin Wang ◽  
Xuan Peng ◽  
Yeda Xiao ◽  
Bo Zhao ◽  
Liying Zhan
Keyword(s):  
Controlled Study ◽  
Intravenous Lidocaine ◽  
Double Blind ◽  
Operative Hysteroscopy ◽  
Throat Pain ◽  
Equivalent Rate ◽  
Operative Recovery ◽  
Double Blinded ◽  
Blinded Trial

Abstract Background The role of intraoperative intravenous lidocaine infusion has been previously evaluated for pain relief, inflammatory response, and post-operative recovery, including in endoscopic surgery. The present study is a randomized double-blinded trial in which we evaluated whether intravenous lidocaine infusion would reduce postoperative pain, propofol requirement and remifentanil consumption in patients undergoing hysteroscopy surgery. Methods Eighty-five patients scheduled to undergo elective operative hysteroscopy surgery under general anesthesia were randomized into two groups. Group L included patients who received an intravenous lidocaine bolus 1.5mg/kg over 3 min followed by a continuous infusion at the rate of 2 mg/kg/h until surgery completed, and Group C received 0.9% normal saline solution at an equivalent rate. The depth of anesthesia was monitored using the Narcotrend, which was based on measurement of the patient’s cerebral electrical activity. Primary outcome of the study was postoperative hypogastric pain evaluating by visual analogue scale (VAS). Secondary outcomes include propofol requirement and remifentanil requirement. Results VAS score of Group L was significantly lower than Group C at postoperative 0.5 h, 4 h, respectively (P < 0.05), while no obvious difference was found at postoperative 24 h. There was no difference between groups in propofol requirement, but Group L required less dosage of remifentanil than Group C (P < 0.05). Moreover, the incidence of throat pain was significantly lower in Group L. No adverse events associated with lidocaine was discovered. Conclusions Administration of intravenous lidocaine infusion as an adjuvant alleviated short-term postoperative hypogastric pain and throat pain, and reduced remifentanil requirement in patients undergoing operative hysteroscopy surgery.

scholarly journals The role of oxytocin in modulating self-other distinction brain: a pharmacological fMRI study

2021 ◽  
Author(s):  
Yuanchen Wang ◽  
Ruien Wang ◽  
Haiyan Wu
Keyword(s):  
Left Hemisphere ◽  
Face Perception ◽  
The Self ◽  
Controlled Study ◽  
Neural Basis ◽  
Fmri Study ◽  
Fmri Analysis ◽  
Double Blinded ◽  
Better Than

The self-other distinction is crucial in human social cognition and social interaction. Studies have found that oxytocin (OT) sharpens the self-other perceptual boundary but with mixed results. Further, little is known if the effect of OT on self-resemblance face perception exists, especially on its neural basis. Moreover, it is unclear if OT would influence the judgment in self-other discrimination when the other is a child or an adult. In the current double-blinded, placebo-controlled study, we investigated the effect of OT on self-face perception at both behavioral and neural levels. We morphed their faces with either an adult, a child, or a stranger face of either an adult or child. After being treated by either OT or placebo (PL), participants reported whether a morphed face resembles themselves while being scanned with fMRI. Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. fMRI results showed that the OT group exhibited generally increased activities in the visual area and IFG for self-morphed faces. Such difference was more pronounced in the adult face compared to child face conditions. Multivariate fMRI analysis revealed that the OT group showed better classification between self-morphed versus other-morphed faces, indicating that OT increased self-other distinction, especially for adult faces and in the left hemisphere. Our study shows the significant effect of OT on self-referential brain processes, providing evidence for the potential OT's effect on a left hemisphere self network

scholarly journals Investigation of Risperidone Treatment Associated With Enhanced Brain Activity in Patients Who Stutter

2021 ◽  
Vol 15 ◽  
Author(s):  
Gerald A. Maguire ◽  
Bo Ram Yoo ◽  
Shahriar SheikhBahaei
Keyword(s):  
Serotonin Receptor ◽  
Brain Activity ◽  
Controlled Study ◽  
Positron Emission ◽  
Pre Treatment ◽  
Double Blinded ◽  
The Brain ◽  
Risperidone Treatment ◽  
Neuroimaging Techniques

Stuttering is a childhood onset fluency disorder that leads to impairment in speech. A randomized, double-blinded placebo-controlled study was conducted with 10 adult subjects to observe the effects of risperidone (a dopamine receptor 2/serotonin receptor 2 antagonist) on brain metabolism, using [18F] deoxyglucose as the marker. At baseline and after 6 weeks of taking risperidone (0.5–2.0 mg/day) or a placebo pill, participants were assigned to a solo reading aloud task for 30 min and subsequently underwent a 90-min positron emission tomography scan. Paired t-tests were performed to compare the pre-treatment vs. post-treatment in groups. After imaging and analysis, the blind was broken, which revealed an equal number of subjects of those on risperidone and those on placebo. There were no significant differences in the baseline scans taken before medication randomization. However, scans taken after active treatment demonstrated higher glucose uptake in the specific regions of the brain for those in the risperidone treatment group (p &lt; 0.05). Risperidone treatment was associated with increased metabolism in the left striatum, which consists of the caudate and putamen, and the Broca’s area. The current study strengthens previous research that suggests the role of elevated dopamine activity and striatal hypometabolism in stuttering. We propose that the mechanism of risperidone’s action in stuttering, in part, involves increased metabolism of striatal astrocytes. We conclude that using neuroimaging techniques to visualize changes in the brain of those who stutter can provide valuable insights into the pathophysiology of the disorder and guide the development of future interventions.

Sign in / Sign up

Export Citation Format

Share Document