scholarly journals Early verrucous cell carcinoma of the esophagus: a case report and endoscopic and histologic features

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lianjun Di ◽  
Xinglong Wu ◽  
Zhenyu Chen ◽  
Jianhong Zhu ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Early Detection ◽  
Cell Carcinoma ◽  
Poor Prognosis ◽  
Narrow Band Imaging ◽  
Early Esophageal Cancer ◽  
Carcinoma Of The Esophagus ◽  
White Light Endoscopy ◽  
Swallowing Dysfunction ◽  
History Of ◽  
Excessive Alcohol

Abstract Background Verrucous cell carcinoma of the esophagus (VCCE) is an extremely rare tumor and generally detected at advanced stage. Despite of its slow growth and well differentiation, it has very poor prognosis with high mortality. Therefore, early detection is a critical to improve patients’ survival. However, no early cases of VCCE have been reported and the endoscopic features of early VCCE are not well described. We herein report the endoscopic and histologic features of an early VCCE. Case presentation A 54-year-old man with a history of excessive alcohol and tobacco use was admitted to our hospital because of chronic persistent swallowing dysfunction for six months. White light endoscopy revealed a flat lesion covered with scattered leukoplakia in the middle esophagus. Magnifying endoscopy with narrow-band imaging showed tiny irregular papillary microsurface structure. The lesion was considered as early esophageal cancer and completely resected with endoscopic submucosal dissection. Histological examination confirmed that the lesion was early VCCE which was limited within the mucosal lamina propria (m2). Conclusion VCCE is rare with poor prognosis. This is a report of early VCCE and description of its endoscopic features which will contribute to early detection of these cancers.

scholarly journals Rare presentation of a squamous cell carcinoma originating from gastric compartment 1 in an alpaca

2020 ◽  
Vol 89 (5) ◽  
pp. 279-283
Author(s):  
K. Rosiers ◽  
M. Strubbe ◽  
T. Flahou ◽  
H. Versnaeyen ◽  
R. Ducatelle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Large Firm ◽  
Histological Investigation ◽  
Rare Presentation ◽  
Dorsal Wall ◽  
History Of ◽  
Progressive Weakness

A twenty-year-old, male, intact alpaca with a history of anorexia, progressive weakness and recumbency was euthanized because of a poor prognosis and clinical deterioration. The animal was submitted for necropsy at the pathology department of Dierengezondheidszorg Vlaanderen (DGZ) diagnostic lab. A full necropsy was performed and showed a large firm white mass measuring 18x8x10 cm attached to the dorsal wall of gastric compartment 1 (C1) and expanding to the abdominal aorta. Miliary small white metastatic nodules were present on the pleura and peritoneum (carcinomatosis). Multiple small white metastatic nodules were also present in the parenchyma of the liver. On histological investigation, this neoplasia was characterized as squamous cell carcinoma (SCC).

scholarly journals Role of narrow band imaging in the detection of mucosal lesions of head and neck

2020 ◽  
Vol 6 (9) ◽  
pp. 1678
Author(s):  
Pranay Bhandari ◽  
Kavita Sachdeva
Keyword(s):  
Early Detection ◽  
Head And Neck ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Early Stage ◽  
Early Screening ◽  
White Light Endoscopy ◽  
Promising Tool ◽  
Mucosal Lesions

<p class="abstract"><strong>Background: </strong>Head and neck mucosal lesions are difficult to diagnose at early stage; therefore, they usually present at an advance phase. Narrow Band imaging (NBI) first came to use around 2005 and became one of the most used technologies for image enhanced endoscopy.</p><p class="abstract"><strong>Material and method: </strong>In order to identify best method for early detection of mucosal lesion of head and neck, we examined patients with suspected lesions first under white light endoscopy then under NBI endoscopy. Patients under-went biopsy thereafter, and results were compared. Our aim was to evaluate the role of NBI as a screening tool in the early detection of mucosal lesions of head and neck.</p><p class="abstract"><strong>Result:</strong> It was observed that NBI is useful tool in identifying mucosal lesions of head and neck early. 71 patients were included in our study and it was observed that NBI endoscopy shows 100% sensitivity, 96.36% specificity and 97.18% accuracy in identifying benign lesions. It shows 100% sensitivity, 94.74% specificity and 98.59% accuracy in identifying malignant lesions.</p><p class="abstract"><strong>Conclusion:</strong> In our study we came to conclusion that NBI is very promising tool for early screening purposes of mucosal lesions of head and neck which were missed in routine examination.</p>

Mo1033 Natural History of Superficial Head and Neck Squamous Cell Carcinoma Under Follow-Up Endoscopic Observation With Narrow Band Imaging

2016 ◽  
Vol 83 (5) ◽  
pp. AB436
Author(s):  
Hiroshi Nakamura ◽  
Tomonori Yano ◽  
Satoshi Fujii ◽  
Tomohiro Kadota ◽  
Toshifumi Tomioka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Endoscopic Observation ◽  
History Of

Hypercalcemia related to the poor prognosis of patients with squamous cell carcinoma of the esophagus

1989 ◽  
Vol 42 (4) ◽  
pp. 229-233 ◽  
Author(s):  
Hiroyuki Kuwano ◽  
Hideo Baba ◽  
Hiroyuki Matsuda ◽  
Shinji Ohno ◽  
Masaki Mori ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Carcinoma Of The Esophagus ◽  
The Poor

Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma

Nanoscale ◽  
2021 ◽  
Author(s):  
Qingfu Zhu ◽  
Huang Liu ◽  
Qinsi Yang ◽  
Zheng Ao ◽  
Rui Yang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Early Detection ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Mortality ◽  
Poor Prognosis ◽  
Mortality Rates ◽  
Metabolomic Analysis

Esophageal squamous cell carcinoma (ESCC) is a worldwide malignancy with high mortality rates and poor prognosis due to the lack of effective biomarkers for early detection. Exosomes have been extensively...

scholarly journals A case of esophageal squamous cell carcinoma metastasized to the colonic anastomotic site of right hemicolectomy

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S64-S64
Author(s):  
Y Zhang ◽  
Y Nakanishi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Right Hemicolectomy ◽  
Anastomotic Site ◽  
Carcinoma Of The Esophagus ◽  
History Of ◽  
Poorly Differentiated ◽  
Ileocolonic Anastomosis

Abstract Introduction/Objective Although squamous cell carcinoma of the esophagus rarely metastasizes to the uncommon sites, colonic metastasis from squamous cell carcinoma of the esophagus is extremely rare. There has been no case report of colonic metastasis from squamous cell carcinoma of the esophagus to an anastomotic site of the colon. Methods/Case Report A 73-year-old female with a history of right hemicolectomy for advanced ascending colon cancer in 2006 was referred to our facility for a two-month history of solid food dysphagia. The patient has been followed up in the survivorship clinic for surveillance with no evidence of recurrence for 13 years to date. An esophagogastroduodenoscopy revealed a 7 cm fungating and ulcerated mass in the middle to lower esophagus. The biopsy from the esophageal mass showed a moderately to poorly differentiated squamous cell carcinoma. A colonoscopy showed an end-to-end ileocolonic anastomosis with a 7 mm ulceration in the transverse colon. The biopsy from the ulceration at the anastomotic site showed a moderately to poorly differentiated squamous cell carcinoma. Immunostains performed on both esophageal and colonic biopsies demonstrate that the tumor cells in both esophageal and colonic biopsies are positive for p40, p63, p16, and negative for CK7, CK20, and CDX2. The diagnosis of metastatic esophageal squamous cell carcinoma to the colonic anastomotic site of previous right hemicolectomy was rendered based on the morphology and immunoprofile. A subsequent computed tomography (CT) and positron emission tomography (PET) demonstrated no other distant metastases. Chemotherapy with 5-FU and oxaliplatin has been started. A metastasis to the anastomotic site is extremely rare. Although the anastomotic site might be a good niche for cancer cells to metastasize to, the pathogenesis of a metastasis to the anastomotic site remains unknown. Our case is very intriguing because a metastasis occurred at the anastomosis site, and no other metastasis was found. Results (if a Case Study enter NA) N/A Conclusion We have reported the first case of metastatic esophageal squamous cell carcinoma to the colonic anastomotic site of previous right hemicolectomy in a 73-year-old female. Although the pathogenesis of a metastasis to the anastomotic site remains unknown, the possibility of contribution of surgical trauma to metastasis formation at the ileocolonic anastomosis cannot be completely ruled out.

scholarly journals Malignant and premalignant lesions of the tongue, clinical and histopathological findings for their early detection. Study of two cases

2020 ◽  
Author(s):  
Adel Martinez-Martinez ◽  
Antonio Diaz-Caballero ◽  
Natalia Quintero-Echenique
Keyword(s):  
Squamous Cell Carcinoma ◽  
Alcohol Consumption ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tobacco Consumption ◽  
Premalignant Lesions ◽  
Hpv Dna ◽  
History Of ◽  
Male Patients

  Background: Squamous cell carcinoma affects subjects between the sixth and seventh decade of life. However, there are growing reports on the involvement of young adults. Clinical Cases: Two male patients aged 40 and 55, with no history of tobacco consumption and occasional alcohol consumption. They presented an exophytic ulcer and a white plaque on the lateral border of the tongue, the first diagnosed as moderately differentiated squamous cell carcinoma without HPV DNA genotypes and the second as leukoplakia without dysplasia. Conclusions: Risk factors commonly associated with potentially malign disorders and oral cancer, such as smoking and alcohol consumption, were not involved in the present cases. Therefore identify clinical, histopathological and molecular findings, allows the early detection of them, improving the prognosis of these patients.

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