scholarly journals Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jing Li ◽  
Gang Chen ◽  
Mingmin Zhang ◽  
Shenghao Tu ◽  
Chao Chen

Abstract Background The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 has spread rapidly worldwide and disease spread is currently increasing. Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive therapy on COVID-19 infection are lacking. Case presentation We report two cases of COVID-19 infection in renal transplant recipients with variable clinical presentations. The first patient presented with mild respiratory symptoms and a stable clinical course. The second patient had more severe clinical characteristics and presented with severe pneumonia and multi-organ failure. Both patients received a combination therapy including antiviral treatment and reduced immunosuppression therapy and finally recovered. Conclusions We report COVID-19 infection in two renal transplant recipients with a favorable outcome but different clinical courses, which may provide a reference value for treating such patients.

2020 ◽  
Author(s):  
Jing Li ◽  
Gang Chen ◽  
chao chen

Abstract Background: The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 has spread rapidly worldwide and disease spread is currently increasing. The clinical picture of transplant recipients and the effect of the anti-rejection immunosuppressive regimens on the clinical course of COVID-19 are lacking.Case presentation: We report two cases of COVID-19infection in renal transplant recipients with variable clinical presentations. The first patient presented with mild respiratory symptoms and a stableclinical course. The second patient had more severe clinical characteristics and presented with severe pneumonia and multi-organ failure. Both patients received a combination therapy including antiviral treatment and reducedimmunosuppressiontherapy and finally recovered.Conclusions: We report COVID-19 infectionin two renal transplant recipients with a favorable outcome but different clinical courses, which may provide a reference valuefor treating such patients. Additional data are needed to gain a better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity, and outcome of COVID-19in solid organ transplant recipients.


2003 ◽  
pp. 994-998 ◽  
Author(s):  
Maria T. Sartori ◽  
Paolo Rigotti ◽  
Francesco Marchini ◽  
Luca Spiezia ◽  
Nicola Baldan ◽  
...  

2014 ◽  
Vol 40 (6) ◽  
pp. 914-915 ◽  
Author(s):  
Guo-wei Tu ◽  
Min-jie Ju ◽  
Yi-jun Zheng ◽  
Du-ming Zhu ◽  
Ming Xu ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document