scholarly journals Deep learning-based pancreas volume assessment in individuals with type 1 diabetes

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Raphael Roger ◽  
Melissa A. Hilmes ◽  
Jonathan M. Williams ◽  
Daniel J. Moore ◽  
Alvin C. Powers ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Deep Learning ◽  
Volume Measurement ◽  
Training Data ◽  
Human Pancreas ◽  
Abdominal Magnetic Resonance Imaging ◽  
Clinical Databases ◽  
Mri Scans ◽  
Pancreas Volume

AbstractPancreas volume is reduced in individuals with diabetes and in autoantibody positive individuals at high risk for developing type 1 diabetes (T1D). Studies investigating pancreas volume are underway to assess pancreas volume in large clinical databases and studies, but manual pancreas annotation is time-consuming and subjective, preventing extension to large studies and databases. This study develops deep learning for automated pancreas volume measurement in individuals with diabetes. A convolutional neural network was trained using manual pancreas annotation on 160 abdominal magnetic resonance imaging (MRI) scans from individuals with T1D, controls, or a combination thereof. Models trained using each cohort were then tested on scans of 25 individuals with T1D. Deep learning and manual segmentations of the pancreas displayed high overlap (Dice coefficient = 0.81) and excellent correlation of pancreas volume measurements (R2 = 0.94). Correlation was highest when training data included individuals both with and without T1D. The pancreas of individuals with T1D can be automatically segmented to measure pancreas volume. This algorithm can be applied to large imaging datasets to quantify the spectrum of human pancreas volume.

scholarly journals Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset

Diabetes Care ◽  
2018 ◽  
Vol 42 (2) ◽  
pp. 248-257 ◽  
Author(s):  
John Virostko ◽  
Jon Williams ◽  
Melissa Hilmes ◽  
Chris Bowman ◽  
Jordan J. Wright ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Disease Onset ◽  
First Year ◽  
Pancreas Volume

scholarly journals Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Brittany S. Bruggeman ◽  
Martha Campbell-Thompson ◽  
Stephanie L. Filipp ◽  
Matthew J. Gurka ◽  
Mark A. Atkinson ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Substance Use ◽  
Type 1 Diabetes ◽  
Chronic Pancreatitis ◽  
Fatty Infiltration ◽  
Organ Donors ◽  
Human Pancreas ◽  
Islet Amyloid ◽  
Control Organ

Access to human pancreas samples from organ donors has greatly advanced our understanding of type 1 diabetes pathogenesis; however, previous studies have shown that donors have a high rate of substance use, and its impact on pancreatic histopathology in this disease is not well described. One-hundred-thirty-one type 1 diabetes and 111 control organ donor pancreata from persons 12-89 years of age (mean 29.8 ± 15.5 years) within the Network for Pancreatic Organ donors with Diabetes (nPOD) were examined for insulin positivity, insulitis, amyloid staining, acute and chronic pancreatitis, and chronic exocrine changes (acinar atrophy, fibrosis, fatty infiltration, or periductal fibrosis); findings were compared by history of substance use. A secondary analysis compared exocrine pancreatic histopathologic findings in type 1 diabetes versus control organ donors regardless of substance use history. We observed a high but congruent rate of substance use in type 1 diabetes and control organ donors (66.4% and 64% respectively). Among donors with type 1 diabetes (but not controls), islet amyloid (OR 9.96 [1.22, 81.29]) and acute pancreatitis (OR 3.2 [1.06, 9.63]) were more common in alcohol users while chronic exocrine changes (OR 8.86 [1.13, 69.31]) were more common in cocaine users. Substance use impacted the pancreata of donors with type 1 diabetes more than controls. Overall, despite similar rates of substance use, acute pancreatitis (15.3% versus 4.5%, p=0.0061), chronic pancreatitis (29.8% versus 9.9%, p=0.0001), and chronic exocrine changes (73.3% versus 36.9%, p<0.0001) were more common in type 1 diabetes donors than controls. Alcohol and/or cocaine use in type 1 diabetes organ donors increases exocrine pancreas pathology and islet amyloid deposition but does not affect insulitis or insulin positivity. Exocrine pathology in type 1 diabetes donors is common, and further study of the pathophysiology of these changes is needed.

scholarly journals Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135663 ◽  
Author(s):  
Tanya C. Burch ◽  
Margaret A. Morris ◽  
Martha Campbell-Thompson ◽  
Alberto Pugliese ◽  
Jerry L. Nadler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Proteomic Analysis ◽  
Human Pancreas ◽  
Unique Signature

scholarly journals Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study

Diabetes Care ◽  
2021 ◽  
Author(s):  
Susan Martin ◽  
Elena P. Sorokin ◽  
E. Louise Thomas ◽  
Naveed Sattar ◽  
Madeleine Cule ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Mendelian Randomization ◽  
Fat Content ◽  
Liver Fat ◽  
Liver And Pancreas ◽  
Pancreas Volume

OBJECTIVE Fat content and volume of liver and pancreas are associated with risk of diabetes in observational studies; whether these associations are causal is unknown. We conducted a Mendelian randomization (MR) study to examine causality of such associations. RESEARCH DESIGN AND METHODS We used genetic variants associated (P < 5 × 10−8) with the exposures (liver and pancreas volume and fat content) using MRI scans of UK Biobank participants (n = 32,859). We obtained summary-level data for risk of type 1 (9,358 cases) and type 2 (55,005 cases) diabetes from the largest available genome-wide association studies. We performed inverse–variance weighted MR as main analysis and several sensitivity analyses to assess pleiotropy and to exclude variants with potential pleiotropic effects. RESULTS Observationally, liver fat and volume were associated with type 2 diabetes (odds ratio per 1 SD higher exposure 2.16 [2.02, 2.31] and 2.11 [1.96, 2.27], respectively). Pancreatic fat was associated with type 2 diabetes (1.42 [1.34, 1.51]) but not type 1 diabetes, and pancreas volume was negatively associated with type 1 diabetes (0.42 [0.36, 0.48]) and type 2 diabetes (0.73 [0.68, 0.78]). MR analysis provided evidence only for a causal role of liver fat and pancreas volume in risk of type 2 diabetes (1.27 [1.08, 1.49] or 27% increased risk and 0.76 [0.62, 0.94] or 24% decreased risk per 1SD, respectively) and no causal associations with type 1 diabetes. CONCLUSIONS Our findings assist in understanding the causal role of ectopic fat in the liver and pancreas and of organ volume in the pathophysiology of type 1 and 2 diabetes.

546-P: Deep Learning Predictions of Diabetic Retinopathy Associated with Progression of Renal Disease in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 546-P
Author(s):  
JOSEPH C. MELLOR ◽  
AMOS J. STORKEY ◽  
HELEN COLHOUN ◽  
PAUL M. MCKEIGUE ◽  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Renal Disease ◽  
Progression Of Renal Disease

349-OR: Pancreas Volume Is Smaller in Individuals with Stage 1 Type 1 Diabetes (T1D) and Correlates with Disease Progression

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 349-OR
Author(s):  
JOHN VIROSTKO ◽  
JONATHAN M. WILLIAMS ◽  
MELISSA A. HILMES ◽  
JORDAN J. WRIGHT ◽  
BRENNA D. HAMMEL ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Disease Progression ◽  
Pancreas Volume ◽  
Stage 1

scholarly journals Pluripotent Stem Cell-Derived Pancreatic Progenitors and β-Like Cells for Type 1 Diabetes Treatment

Physiology ◽  
2018 ◽  
Vol 33 (6) ◽  
pp. 394-402 ◽  
Author(s):  
Rangarajan Sambathkumar ◽  
Adriana Migliorini ◽  
Maria Cristina Nostro
Keyword(s):  
Type 1 Diabetes ◽  
Pluripotent Stem Cells ◽  
Specific Cell ◽  
Human Pancreas ◽  
Cell Replacement Therapy ◽  
Pancreatic Progenitors ◽  
Specific Cell Surface

In this review, we focus on the processes guiding human pancreas development and provide an update on methods to efficiently generate pancreatic progenitors (PPs) and β-like cells in vitro from human pluripotent stem cells (hPSCs). Furthermore, we assess the strengths and weaknesses of using PPs and β-like cell for cell replacement therapy for the treatment of Type 1 diabetes with respect to cell manufacturing, engrafting, functionality, and safety. Finally, we discuss the identification and use of specific cell surface markers to generate safer populations of PPs for clinical translation and to study the development of PPs in vivo and in vitro.

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