scholarly journals Use of metabolomics for the identification and validation of clinical biomarkers for preterm birth: Preterm SAMBA

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Jose G. Cecatti ◽  
◽  
Renato T. Souza ◽  
Karolina Sulek ◽  
Maria L. Costa ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Clinical Biomarkers ◽  
Birth Preterm

scholarly journals Reducing the impact of preterm birth: Preterm birth commissioning in the United Kingdom

2019 ◽  
Vol 3 ◽  
pp. 100018 ◽  
Author(s):  
Lisa Story ◽  
Nigel A.B. Simpson ◽  
Anna L. David ◽  
Zarko Alfirevic Z ◽  
Phillip R. Bennett ◽  
...  
Keyword(s):  
United Kingdom ◽  
Preterm Birth ◽  
The United Kingdom ◽  
The Impact ◽  
Birth Preterm

Preterm birth

2020 ◽  
pp. 374-388
Author(s):  
Angharad Care ◽  
Zarko Alfirevic
Keyword(s):  
Preterm Birth ◽  
Individual Risk ◽  
Novel Therapies ◽  
Spontaneous Preterm Birth ◽  
Healthcare Settings ◽  
Upper Limit ◽  
Environmental Interactions ◽  
Prediction And Prevention ◽  
Limit Of Viability ◽  
Birth Preterm

This chapter discusses the epidemiology, prediction, prevention, and management of spontaneous preterm birth. Preterm birth is usually defined as delivery at any gestation before 37 completed weeks of pregnancy (<37+0 weeks, <259 days). The lower limit of preterm birth and upper limit of late spontaneous miscarriage are blurred as the limit of viability varies with differences in healthcare settings. This condition remains one of the biggest challenges facing obstetricians globally as a result of continuing high rates of morbidity and mortality. Spontaneous preterm birth is caused by a complex collection of pathophysiology with overlapping environmental interactions and behavioural influences that contribute to individual risk. Much debate exists regarding best prevention therapies and there remains a huge need for novel therapies and interventions for both prediction and prevention

Maternal Cancer During Pregnancy and Risks of Stillbirth and Infant Mortality

2017 ◽  
Vol 35 (14) ◽  
pp. 1522-1529 ◽  
Author(s):  
Donghao Lu ◽  
Jonas F. Ludvigsson ◽  
Karin E. Smedby ◽  
Katja Fall ◽  
Unnur Valdimarsdóttir ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Infant Mortality ◽  
Neonatal Mortality ◽  
Fetal Growth ◽  
Preterm Births ◽  
Positive Association ◽  
Spontaneous Preterm Birth ◽  
Rate Ratios ◽  
Birth Preterm ◽  
Number Of Births

Purpose To examine whether maternal cancer during pregnancy is associated with increased risks of stillbirth and infant mortality. Methods On the basis of nationwide health registers, we conducted a study of 3,947,215 singleton births in Sweden from 1973 through 2012. Exposure was defined as maternal cancer diagnosed during pregnancy (number of births = 984) or during the year after pregnancy (number of births = 2,723). We calculated incidence rate ratios (IRRs) for stillbirth and infant mortality, comparing exposed births to unexposed births. Small-for-gestational-age (SGA) and preterm births were examined as secondary outcomes. Results Maternal cancer diagnosed during pregnancy was positively associated with stillbirth (IRR, 2.5; 95% CI, 1.2 to 5.0), mainly stillbirths assessed as SGA (IRR, 4.9; 95% CI, 2.2 to 11.0), and with preterm SGA births (relative risk 3.0; 95% CI, 2.1 to 4.4). Positive associations of maternal cancer diagnosed during pregnancy or the year after pregnancy were noted for both neonatal mortality (deaths within 0 to 27 days; IRR, 2.7; 95% CI, 1.3 to 5.6 and IRR, 2.0; 95% CI, 1.2 to 3.2, respectively) and preterm birth (IRR, 5.8; 95% CI, 5.3 to 6.5 and IRR, 1.6; 95% CI, 1.4 to 1.8, respectively). The positive association with preterm birth was due to iatrogenic instead of spontaneous preterm birth. Preterm birth explained 89% of the association of maternal cancer during pregnancy with neonatal mortality. Conclusion Maternal cancer during pregnancy is associated with increased risks of rare but fatal outcomes, including stillbirth and neonatal mortality. This may be due to conditions associated with fetal growth restriction and iatrogenic preterm birth. Careful monitoring of fetal growth and cautious decision making on preterm delivery should therefore be reinforced.

Predicting Preterm Birth in Twin Pregnancy: Was the Previous Birth Preterm? A Canadian Experience

2013 ◽  
Vol 35 (9) ◽  
pp. 793-801 ◽  
Author(s):  
Audrey Michaluk ◽  
Marie-Danielle Dionne ◽  
Stephanie Gazdovich ◽  
Danielle Buch ◽  
Thierry Ducruet ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Twin Pregnancy ◽  
Canadian Experience ◽  
Previous Birth ◽  
Birth Preterm

Accuracy of Phosphorylated Insulin-Like Growth Factor Binding Protein-1 in Predicting Preterm Labour

2020 ◽  
Vol 13 (2) ◽  
pp. 134-138
Author(s):  
Elitsa H. Gyokova ◽  
Yordan D. Popov ◽  
Yoana G. Ivanova-Yoncheva ◽  
Kamelia K. Dimitrova ◽  
Klaudia I. Dekova
Keyword(s):  
Preterm Birth ◽  
Growth Factor ◽  
Preterm Labour ◽  
Binding Protein ◽  
Cervical Length ◽  
Morbidity And Mortality ◽  
Premature Delivery ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Clinical Biomarkers

Summary Preterm birth is the most common cause of perinatal morbidity and mortality worldwide. The routine method for predicting premature birth is the measurement of the cervical length. However, to make a better and more precise prognosis, the cervicovaginal fluid (CVF) was widely inspected through many studies. Its content is used nowadays as a diagnostic method for different conditions. One of the clinical biomarkers used to predict preterm labour in the CVF is the phosphorylated insulin-like growth factor binding protein-1 (pIGFBP-1). This study aimed to evaluate the accuracy of pIGFBP-1 as a predictor of preterm labour when used with cervical biometrics. A prospective, cross-sectional study was conducted on pregnant patients, divided into groups: Group A included participants at risk for premature labour, and Group B -women with an uncomplicated pregnancy. All patients underwent a test for pIGFBP-1, followed by a transvaginal measurement of the cervical length. A total of 32 patients were recruited for the study. Their pregnancy outcomes were followed up. In the group of symptomatic patients, the results were positive in 8 patients, and despite the intensive tocolytic therapy given, 5 of them gave preterm birth within 14 days. There were two patients with a cervical length of less than 10 mm. They both had positive results for pIGFBP-1 and gave spontaneous preterm birth within a few hours. The predictive value of pIGFBP-1 in cases with negative results was high. The leading cause for fetal morbidity and mortality in the twenty-first century remains premature delivery. Many investigations are currently carried out, aiming to facilitate preterm labor prediction and quickly estimate a pregnant woman’s ability to carry to time. The patients at highest risk are detected by measuring the cervical length. Newly searched clinical biomarkers such as fetal fibronectin found in the CVF might help predict preterm birth in time.

scholarly journals The association between maternal and offspring preterm birth. Results from a sibling design

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Marcelo Urquia
Keyword(s):  
Preterm Birth ◽  
Fixed Effects ◽  
Estimating Equation ◽  
Adjusted Relative Risk ◽  
Preterm Baby ◽  
Sibling Design ◽  
Quasi Experimental ◽  
History Of ◽  
Intergenerational Patterns ◽  
Birth Preterm

IntroductionPrevious studies have reported an intergenerational association between maternal and offspring preterm birth (PTB) but the nature of the association remains unclear. Objectives and ApproachThe objective was to revisit the association between maternal and offspring preterm birth using a quasi-experimental sibling design and distinguishing between preterm birth types. We conducted a retrospective intergenerational cohort study of 39,573 women born singleton in Manitoba, Canada (1980-2002) who gave birth to 79,198 singleton infants (1995-2016). To account for familial confounding we defined a matched subcohort of 1033 sister mothers with discordant PTB status and compared offspring PTB rates between 2,499 differentially exposed cousins using log-binomial fixed-effects generalized estimating equation models. PTB was defined as a delivery < 37 gestation weeks, divided into spontaneous and provider-initiated. ResultsIn the population, mothers born preterm were more likely to give birth preterm [Adjusted Relative Risk (ARR): 1.39; 95\% Confidence Interval (CI): 1.25, 1.54]. The intergenerational association was not apparent among births to sisters with discordant PTB status [ARR: 1.02; 95\% CI: 0.77, 1.34]. However, the lack of association in the sibling analyses is explained by the fact that infants whose maternal aunts, but not their mothers, were born preterm had similarly elevated risk of PTB (10\%) than infants whose mothers were born preterm. Intergenerational patterns were observed for spontaneous PTB but not for provider-initiated PTB. Conclusion/ImplicationsThese findings suggest that it is not the fact of having been born preterm that puts women at higher risk of delivering preterm, but the fact of having been born to a mother who ever delivered a preterm baby. Consideration of family history of PTB may better identify women-at-risk.

scholarly journals Relação entre a qualidade da assistência pré-natal e a prematuridade: Uma revisão integrativa

2016 ◽  
Vol 6 (2) ◽  
pp. 01 ◽  
Author(s):  
Vanessa Andréia Wachholz ◽  
Melissa Guterres Costa ◽  
Nalú Pereira da Costa Kerber ◽  
Carla Vitola Gonçalves ◽  
Diego Vasconcelos Ramos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Prenatal Care ◽  
Premature Birth ◽  
Preterm Labor ◽  
High Rate ◽  
Electronic Library ◽  
The Subject ◽  
Birth Preterm

A prematuridade é um dos grandes problemas de saúde pública, por contribuir fortemente para a elevada taxa de morbimortalidade infantil. Possíveis fatores de risco que colaboram para sua ocorrência têm sido investigados, dentre eles a assistência pré-natal, pois a mesma é elencada em virtude de, por meio dela, ser possível prevenir, diagnosticar e tratar eventos indesejáveis que possam resultar em danos para mãe e o recém-nascido. Objetivou-se identificar a produção cientifica sobre a associação entre a prematuridade e a qualidade da assistência pré-natal. Revisão integrativa com coleta de dados realizada de março a junho de 2014 utilizando o descritor trabalho de parto prematuro nas bases de dados Scientific Eletronic Library Online e Literatura Internacional em Ciências da Saúde. Os artigos foram organizados conforme o assunto abordado, sendo criadas três categorias: fatores de risco para o parto prematuro, prevenção ao parto prematuro e assistência pré-natal e parto prematuro. Embora tenham sido encontrados poucos estudos relacionando o parto prematuro e a realização do pré-natal, cabe ressaltar a importância da realização de uma assistência pré-natal adequada, de acordo com o que o Ministério da Saúde preconiza por meio de uma rotina mínima. Ela é importante para detectar e tratar precocemente determinadas complicações que levam, entre outros desfechos indesejáveis, ao parto prematuro. Relationship between the quality of service pre -natal and a prematurity: An integrative reviewAbstract: Prematurity is a one of the major problem of public health, for contributing to the high rate of infant morbidity and mortality. Possible risk factors that collaborate to their occurrence have been investigated, including prenatal assistance, because through it, be possible to prevent, diagnose and treat adverse events that may result in damage to mother and the newborn. The objective identify the scientific production on the association between prematurity and the quality of prenatal care. Integrative review with data collection carried out from March to June 2014 using the descriptor preterm labor in databases Scientific Electronic Library Online and International Literature on Health Sciences. The articles were organized according to the subject matter, being created three categories: risk factors for preterm birth, preterm labor prevention and prenatal care and preterm birth. Although they have been found few studies relating the premature birth and the completion of prenatal care, it is important to stress the importance of a proper prenatal care, according to the Ministry of Health recommends using a minimum routine. It is important to detect and treat early certain complications that lead, among other undesirable outcomes, to premature birth.

Folate Use Before Conception May Avert Preterm Birth

Ob Gyn News ◽  
2008 ◽  
Vol 43 (5) ◽  
pp. 1-4
Author(s):  
PATRICE WENDLING
Keyword(s):  
Preterm Birth
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