scholarly journals The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Masatsune Shibutani ◽  
Kiyoshi Maeda ◽  
Hisashi Nagahara ◽  
Hiroshi Ohtani ◽  
Yasuhito Iseki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Significance ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer over age 80: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Hisada ◽  
Yu Takahashi ◽  
Manabu Kubota ◽  
Haruhisa Shimura ◽  
Ei Itobayashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Elderly Patients ◽  
Metastatic Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Prognostic Nutritional Index ◽  
Hazard Ratio ◽  
Elderly Group ◽  
Younger Patients ◽  
Nutritional Index

Abstract Background Colorectal cancer (CRC) is one of the most common cancers in the world. The number of elderly patients with CRC increases due to aging of the population. There are few studies that examined chemotherapy and prognostic factors in metastatic colorectal cancer (mCRC) patients aged ≥ 80 years. We assessed the efficacy of chemotherapy and prognostic factors among patients with mCRC aged ≥ 80 years. Methods We retrospectively analyzed clinical and laboratory findings of 987 patients newly diagnosed with CRC at Asahi General Hospital (Chiba, Japan) between January 2012 and December 2016. The Kaplan–Meier method was used for the overall survival (OS) and the log-rank test was used to identify difference between patients. A multivariate Cox proportional hazard regression analysis was performed to determine the hazard ratios and 95% confidence intervals (CIs) of prognostic factors among super-elderly patients. Results In total, 260 patients were diagnosed with mCRC (super-elderly group: n = 43, aged ≥ 80 years and younger group, n = 217, aged < 80 years). The performance status and nutritional status were worse in the super-elderly group than in the younger group. The OS of super-elderly patients who received chemotherapy was worse than that of younger patients (18.5 vs. 28.8 months; P = 0.052), although the difference was not significant. The OS of patients who received chemotherapy tended to be longer than that of those who did not; however, there were no significant differences in OS in the super-elderly group (18.5 vs. 8.4 months P = 0.33). Multivariate analysis revealed that carcinoembryonic antigen levels ≥ 5 ng/mL (hazard ratio: 2.27; 95% CI 1.09–4.74; P = 0.03) and prognostic nutritional index ≤ 35 (hazard ratio: 8.57; 95% CI 2.63–27.9; P = 0.0003) were independently associated with poor OS in the super-elderly group. Conclusions Patients with mCRC aged ≥ 80 years had lower OS than younger patients even though they received chemotherapy. Carcinoembryonic antigen and prognostic nutritional index were independent prognostic factors in super-elderly patients with mCRC, but chemotherapy was not. Trial registration: retrospectively registered.

scholarly journals Prognostic nutritional index in colorectal cancer.

1988 ◽  
Vol 21 (4) ◽  
pp. 1068-1074 ◽  
Author(s):  
Kimiyoshi SHIMANUKI ◽  
Atushi CHIBA ◽  
Kunihiro ITABASHI ◽  
Hiroshi ASANO ◽  
Osami HAMADA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Prognostic significance of preoperative prognostic nutritional index in hepatocellular carcinoma: a meta-analysis

HPB ◽  
2018 ◽  
Vol 20 (10) ◽  
pp. 888-895 ◽  
Author(s):  
Zhongran Man ◽  
Qing Pang ◽  
Lei Zhou ◽  
Yong Wang ◽  
Xiaosi Hu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

Prognostic value of the preoperative prognostic nutritional index in oldest-old patients with colorectal cancer

Surgery Today ◽  
2019 ◽  
Vol 50 (5) ◽  
pp. 449-459 ◽  
Author(s):  
Tetsuro Tominaga ◽  
Takashi Nonaka ◽  
Makoto Hisanaga ◽  
Akiko Fukuda ◽  
Yukinori Tanoue ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Oldest Old ◽  
Prognostic Nutritional Index ◽  
Old Patients ◽  
Nutritional Index

Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer

2013 ◽  
Vol 37 (11) ◽  
pp. 2688-2692 ◽  
Author(s):  
Yasuhiko Mohri ◽  
Yasuhiro Inoue ◽  
Koji Tanaka ◽  
Junichirou Hiro ◽  
Keiichi Uchida ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Postoperative Outcome ◽  
Prognostic Nutritional Index ◽  
Nutritional Index

scholarly journals Comparison of Systemic Immune-Inflammation Index (SII), Early Warning Score (ANDC) and Prognostic Nutritional Index (PNI) in Hospitalized Patients with Malignancy, and Their Influence on Mortality from COVID-19

2021 ◽  
Author(s):  
Muge Bilge ◽  
Isil Kibar Akilli ◽  
Aylia Yesilova ◽  
Kadriye Kart Yasar
Keyword(s):  
Early Warning ◽  
Prognostic Significance ◽  
Prognostic Nutritional Index ◽  
Biological Indicators ◽  
Early Warning Score ◽  
Hospital Death ◽  
Lymphocyte Ratio ◽  
Nutritional Index ◽  
Mortality Ratio ◽  
Immune Inflammation

Abstract Introduction: COVID-19 pandemic is a serious cause of increased mortality in patients having malignancy. Therefore, to help predict the clinical progression of those patients with COVID-19 who have multiple comorbidities as cancer, we need various indices whose parameters we can easily measure and rapidly calculate. We evaluated several biological indicators based on inflammation and/or nutritional status, such as systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized COVID-19 patients with and without malignancies for a prognostic significance. Methodology: This is a retrospective and observational study on 186 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 75 patients had various malignancies, and the rest (111), having a similar age and comorbidity profile based on propensity score matching, had no malignancy. Results: None of the measures as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (MLR), monocyte to lymphocyte ratio (PLR), SII, PNI or ANDC was found to be significantly different between two groups. Mortality ratio was found to be significantly higher in malignancy group (17,3%). Odds ratio for the mortality, OR:2,39 (%95 CI:1,80 -3,16) was found to be significantly higher for the malignancy group, even though the duration of hospitalization was statistically similar for both groups. PNI was found to be significantly lower for deceased patients compared with survivors in the malignancy group. Contrarily, ANDC was found to be significantly higher for deceased patients in the malignancy group. Conclusions: PNI and ANDC have independent predictive power on determining the in-hospital death in COVID-19 malignancy cases. It is suggested that ANDC seems to be a more sensitive score than SII in COVID-19 cases with malignancies.

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