Introduction. Oral squamous cell carcinoma is the sixth most common carcinoma
in the world. Annually, it accounts for 5% of all newly discovered cancers.
The most important prognostic factor is the stage of the disease. The tumor,
node, and metastasis staging system has been the cornerstone for clinical
classification of oral squamous cell carcinoma. Material and Methods. The
study included 65 patients with oral squamous cell carcinoma who underwent
surgery at the Clinic of Maxillofacial Surgery of the Clinical Center of
Vojvodina in Novi Sad. The tumor, node, and metastasis status was determined
according to 7th and 8th edition of the tumor, node, and metastasis
classification. Results. Statistical differences between the 7th and 8th
edition of tumor, node, and metastasis classification were examined. There
was also a change in the nodal status; in 20% of patients there was a
transition from N1 to N2, as a result of a more precise definition of nodal
status in patients with oral carcinoma. Conclusion. This research has
pointed out the significance of tumor size as a predictive factor in oral
squamous cell carcinoma, which indicates the importance of its local control
(for surgical and radiological treatment). The 8th edition of the tumor,
node, and metastasis classification for oral cavity cancers made a
significant shift by clearly defining depth of tumor invasion into the tumor
status.
Comprehensive analysis of spread through air spaces in lung adenocarcinoma and squamous cell carcinoma using the 8th edition AJCC/UICC staging system