scholarly journals Local detection of microvessels in IDH-wildtype glioblastoma using relative cerebral blood volume: an imaging marker useful for astrocytoma grade 4 classification

BMC Cancer ◽  
2022 ◽  
Vol 22 (1) ◽  
Author(s):  
María del Mar Álvarez-Torres ◽  
Elies Fuster-García ◽  
Javier Juan-Albarracín ◽  
Gaspar Reynés ◽  
Fernando Aparici-Robles ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
High Grade Glioma ◽  
High Grade ◽  
Invasive Approach ◽  
Non Invasive ◽  
Relative Cerebral Blood Volume ◽  
Microvascular Proliferation ◽  
Glioma Classification ◽  
Astrocytoma Grade

Abstract Background The microvessels area (MVA), derived from microvascular proliferation, is a biomarker useful for high-grade glioma classification. Nevertheless, its measurement is costly, labor-intense, and invasive. Finding radiologic correlations with MVA could provide a complementary non-invasive approach without an extra cost and labor intensity and from the first stage. This study aims to correlate imaging markers, such as relative cerebral blood volume (rCBV), and local MVA in IDH-wildtype glioblastoma, and to propose this imaging marker as useful for astrocytoma grade 4 classification. Methods Data from 73 tissue blocks belonging to 17 IDH-wildtype glioblastomas and 7 blocks from 2 IDH-mutant astrocytomas were compiled from the Ivy GAP database. MRI processing and rCBV quantification were carried out using ONCOhabitats methodology. Histologic and MRI co-registration was done manually with experts’ supervision, achieving an accuracy of 88.8% of overlay. Spearman’s correlation was used to analyze the association between rCBV and microvessel area. Mann-Whitney test was used to study differences of rCBV between blocks with presence or absence of microvessels in IDH-wildtype glioblastoma, as well as to find differences with IDH-mutant astrocytoma samples. Results Significant positive correlations were found between rCBV and microvessel area in the IDH-wildtype blocks (p < 0.001), as well as significant differences in rCBV were found between blocks with microvascular proliferation and blocks without it (p < 0.0001). In addition, significant differences in rCBV were found between IDH-wildtype glioblastoma and IDH-mutant astrocytoma samples, being 2–2.5 times higher rCBV values in IDH-wildtype glioblastoma samples. Conclusions The proposed rCBV marker, calculated from diagnostic MRIs, can detect in IDH-wildtype glioblastoma those regions with microvessels from those without it, and it is significantly correlated with local microvessels area. In addition, the proposed rCBV marker can differentiate the IDH mutation status, providing a complementary non-invasive method for high-grade glioma classification.

scholarly journals Parametric Response Map As an Imaging Biomarker to Distinguish Progression From Pseudoprogression in High-Grade Glioma

2010 ◽  
Vol 28 (13) ◽  
pp. 2293-2299 ◽  
Author(s):  
Christina Tsien ◽  
Craig J. Galbán ◽  
Thomas L. Chenevert ◽  
Timothy D. Johnson ◽  
Daniel A. Hamstra ◽  
...  
Keyword(s):  
Blood Volume ◽  
Radiation Effects ◽  
Cerebral Blood Volume ◽  
Radiation Therapy Oncology Group ◽  
High Grade Glioma ◽  
Extent Of Resection ◽  
Imaging Biomarker ◽  
High Grade ◽  
Parametric Response ◽  
True Progression

Purpose To assess whether a new method of quantifying therapy-associated hemodynamic alterations may help to distinguish pseudoprogression from true progression in patients with high-grade glioma. Patients and Methods Patients with high-grade glioma received concurrent chemoradiotherapy. Relative cerebral blood volume (rCBV) and blood flow (rCBF) maps were acquired before chemoradiotherapy and at week 3 during treatment on a prospective institutional review board–approved study. Pseudoprogression was defined as imaging changes 1 to 3 months after chemoradiotherapy that mimic tumor progression but stabilized or improved without change in treatment or for which resection revealed radiation effects only. Clinical and conventional magnetic resonance (MR) parameters, including average percent change of rCBV and CBF, were evaluated as potential predictors of pseudoprogression. Parametric response map (PRM), an innovative, voxel-by-voxel method of image analysis, was also performed. Results Median radiation dose was 72 Gy (range, 60 to 78 Gy). Of 27 patients, stable disease/partial response was noted in 13 patients and apparent progression was noted in 14 patients. Adjuvant temozolomide was continued in all patients. Pseudoprogression occurred in six patients. Based on PRM analysis, a significantly reduced blood volume (PRMrCBV) at week 3 was noted in patients with progressive disease as compared with those with pseudoprogression (P < .01). In contrast, change in average percent rCBV or rCBF, MR tumor volume changes, age, extent of resection, and Radiation Therapy Oncology Group recursive partitioning analysis classification did not distinguish progression from pseudoprogression. Conclusion PRMrCBV at week 3 during chemoradiotherapy is a potential early imaging biomarker of response that may be helpful in distinguishing pseudoprogression from true progression in patients with high-grade glioma.

Correlation of Relative Permeability and Relative Cerebral Blood Volume in High-Grade Cerebral Neoplasms

2006 ◽  
Vol 187 (4) ◽  
pp. 1036-1042 ◽  
Author(s):  
James M. Provenzale ◽  
Gerald York ◽  
Marcelo Galvez Moya ◽  
Lauren Parks ◽  
Michael Choma ◽  
...  
Keyword(s):  
Blood Volume ◽  
Relative Permeability ◽  
Cerebral Blood Volume ◽  
High Grade ◽  
Relative Cerebral Blood Volume ◽  
Cerebral Neoplasms

scholarly journals Detection of local microvascular proliferation in IDH wild-type Glioblastoma using relative Cerebral Blood Volume

2021 ◽  
Author(s):  
María del Mar Álvarez-Torres ◽  
Elies Fuster-García ◽  
Javier Juan-Albarracín ◽  
Gaspar Reynés ◽  
Fernando Aparici-Robles ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Statistical Tests ◽  
Dynamic Susceptibility ◽  
Wild Type ◽  
Dynamic Susceptibility Contrast ◽  
Relative Cerebral Blood Volume ◽  
Microvascular Proliferation ◽  
Susceptibility Contrast ◽  
Definition Of

ABSTRACTBackgroundThe microvascular proliferation (MVP) and the microvessel area (MVA) are known as diagnostic and prognostic biomarkers for glioblastoma; nevertheless, its measurement is costly, labor-intense, and invasive. MRI perfusion biomarkers such as such as relative cerebral blood volume (rCBV) may be a feasible alternative to predict MVP and estimate MVA.PurposeThis study aims to evaluate the detection capacity of MRI markers such as rCBV to detect local microvascular proliferation in IDH wild-type glioblastoma. In addition, we aim to analyze the association between rCBV values and the microvessel area in different regions of the tumor.Study typeRetrospective study.Population and subjectsData from 71 tissue blocks belonging to 17 IDH wild-type glioblastoma patients were compiled from the Ivy GAP database.Field Strength/Sequence1.5T or 3.0T. Pregadolinium and postgadolinium-based contrast agent-enhanced T1-weighted MRI, T2- and FLAIR T2-weighted, and dynamic susceptibility contrast (DSC) T2* perfusion.AssessmentWe analyzed preoperative MRIs to establish the association between the maximum and mean relative cerebral blood volume (rCBVmax and rCBVmean) with the presence/absence of microvascular proliferation and with the microvessel area for each tumor block.Statistical testsSpearman’s correlation and Mann-Whitney test.ResultsSignificant positive correlations were found between rCBV and MVA in the analyzed tumor blocks (p<0.001). Additionally, significant differences in rCBV were found between blocks with MVP and blocks without MVP (p<0.0001).Data conclusionThe rCBV is shown as significantly different in those tissue blocks with microvascular proliferation from those blocks without it, and it is significantly correlated with microvessels area. This method allows a local detection and definition of MVP and MVA in different regions of the glioblastoma since the first diagnostic stage and in a non-invasive way.

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