scholarly journals Post-infection symptoms following two large waterborne outbreaks of Cryptosporidium hominis in Northern Sweden, 2010–2011

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Moa Rehn ◽  
Anders Wallensten ◽  
Micael Widerström ◽  
Mikael Lilja ◽  
Maria Grunewald ◽  
...  
Keyword(s):  
Post Infection ◽  
Northern Sweden ◽  
Cryptosporidium Hominis

scholarly journals Outbreak of Cryptosporidium hominis in northern Sweden: persisting symptoms in a five-year follow-up

2021 ◽  
Author(s):  
Malin Sjöström ◽  
Malin Arvidsson ◽  
Lars Söderström ◽  
Mikael Lilja ◽  
Johan Lindh ◽  
...  
Keyword(s):  
Joint Pain ◽  
Gastrointestinal Symptoms ◽  
Watery Diarrhoea ◽  
Northern Sweden ◽  
Ocular Pain ◽  
Cryptosporidium Hominis ◽  
Waterborne Outbreak ◽  
The City ◽  
Post Infectious

Abstract ObjectivesIn 2010-2011, a waterborne outbreak of the parasite, Cryptosporidium hominis, affected approximately 27,000 inhabitants in the city of Östersund, Sweden. Previous research suggested that post-infectious symptoms, such as gastrointestinal symptoms and joint pain, could persist for up to two years after the initial infection. In this study, we investigated whether the parasite caused post-infectious sequelae for up to five years after the outbreak. This prospective cohort study examined whether individuals infected during the outbreak were more likely than uninfected individuals to report post-infectious symptoms five years later. The participants completed a questionnaire on whether they experienced a list of symptoms. We analysed data using logistic regression and calculated odds ratios with 95% confidence intervals.Results The analysis included 626 individuals. Among the 262 individuals infected during the outbreak, 56.5% reported symptoms at follow-up. Compared to uninfected individuals, infected individuals were significantly more likely to report watery diarrhoea, diarrhoea, swollen joints, abdominal pain, bloating, joint discomfort, acid indigestion, alternating bowel habits, joint pain, ocular pain, nausea, and fatigue at the follow-up, after adjusting for age and sex. Our findings suggested that cryptosporidiosis was mainly associated with gastrointestinal- and joint-related post-infectious symptoms for up to 5 years after the infection.

The Fine Structure of Replicating Simian Adenoviruses in LLC-MK2

1968 ◽  
Vol 26 ◽  
pp. 220-221
Author(s):  
Matias Pardo ◽  
Malcolm Slifkin ◽  
Leonard Merkow ◽  
Marie Sanchez
Keyword(s):  
Tissue Culture ◽  
Post Infection ◽  
Cesium Chloride ◽  
Longitudinal Section ◽  
Tubular Structures ◽  
Virus Particles ◽  
Ultrastructural Studies ◽  
Culture Cells ◽  
Simian Adenovirus ◽  
Infectivity Titer

The simian adenoviruses SV20, SV30 and SA7 have been found to be oncogenic in the Syrian hamster. The growth characteristics and replicative cycle of these viruses in tissue culture therefore appeared appropriate to investigate. Cesium chloride purified simian adenovirus with an infectivity titer of 100 TCID50, was inoculated into monolayers of LLC-MK2 cells. Cells were fixed in osmium tetroxide and embedded for ultrastructural studies at 1, 3, 6, 9, 18, 24, 48, 72, 120 and 192 hours post-infection.At the first hour post-infection, virus particles were adsorbed to the plasmalemma and found within the peripheral cytoplasm of many LLC-MK2 cells (Fig. 1). Although the first detection of infectious virus occurred at 14 hours and infectivity titers did not reach a maximum until 30 hours, intranuclear virus particles were observed by 3 hours in typical adenovirus crystalline array (Fig. 2) by means of electron microscopy. These typical honeycomb arrayed virus particles at 3 hours provided evidence of significant replication in approximately 5 percent of tissue culture cells examined. Simultaneously, a classical nuclear inclusion manifested by peripheral condensation of nuclear chromatin was evident by light microscopy. As early at 6 to 9 hours, unusual intranuclear concentric membranes formed “tubes” which contained linear arranged virus particles (Fig. 3). In transverse or tangential sections, these “tubes” appeared cochlear-like in shape. In longitudinal section, these intranuclear tubular structures contained individual virus particles at various stages of maturation in a linear arranged order. This arrangement resembled “peas in a pod”.

BALB/c mice immunized with UreB and CT require the presence of neutrophils during the second week post-infection to be protected against Helicobacter

2001 ◽  
Vol 120 (5) ◽  
pp. A515-A515
Author(s):  
P ISLER ◽  
F TACHINNICOTTIER ◽  
D BACHMANN ◽  
I CORTHESYTHEULAZ
Keyword(s):  
Post Infection

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

1994 ◽  
Vol 71 (06) ◽  
pp. 768-772 ◽  
Author(s):  
Gerhard Dickneite ◽  
Jörg Czech
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Organ Failure ◽  
Therapeutic Effect ◽  
Disseminated Intravascular Coagulation ◽  
Post Infection ◽  
Thrombin Inhibitor ◽  
Bolus Administration ◽  
Bacterial Burden ◽  
Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

Turbulent Climate Discourses in Northern Sweden

2020 ◽  
Vol 20 (1) ◽  
pp. 10-42
Author(s):  
Flora Mary Bartlett
Keyword(s):  
Climate Change ◽  
Small Town ◽  
Field Research ◽  
Rural Life ◽  
Northern Sweden ◽  
The North ◽  
Local Experience ◽  
Environmental Engagement ◽  
Physical Phenomena ◽  
Crucial Part

I examine how tensions between locals, environmentalists, and State politicians in a small town in northern Sweden are reinforced through national discourses of climate change and sustainability. Turbulence emerges across different scales of responsibility and environmental engagement in Arjeplog as politicians are seen by local inhabitants to be engaging more with the global conversation than with the local experience of living in the north. Moreover, many people view the environmentalist discourses from the politicians in the south, whom they deem to be out of touch with rural life, as threatening to the local experience of nature. These discourses pose a threat to their reliance on petrol, essential for travel, and are experienced locally as a continuation of the south’s historical interference in the region. Based on thirteen months of field research, I argue that mistrust of the various messengers of climate change, including politicians and environmentalists, is a crucial part of the scepticism towards the climate change discourse and that we as researchers need to utilise the strengths of anthropology in examining the reception (or refusal) of climate change. The locals’ mistrust of environment discourses had implications for my positionality, as I was associated with these perceived ‘outsider’ sensibilities. While the anthropology of climate change often focusses on physical impacts and resilience, I argue that we need to pay due attention to the local turbulence surrounding the discourses of climate change, which exist alongside the physical phenomena.  

scholarly journals Population studies in northern Sweden

Hereditas ◽  
2009 ◽  
Vol 73 (2) ◽  
pp. 253-257 ◽  
Author(s):  
L. BECKMAN ◽  
B. CEDERGREN ◽  
M. RASMUSON
Keyword(s):  
Population Studies ◽  
Northern Sweden
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