scholarly journals Epidemiological and clinical characteristics of severe hand-foot-and-mouth disease (HFMD) among children: a 6-year population-based study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yanhao Wang ◽  
Han Zhao ◽  
Rong Ou ◽  
Hua Zhu ◽  
Lidan Gan ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Foot And Mouth Disease ◽  
Population Based ◽  
Mouth Disease ◽  
Population Based Study ◽  
Foot And Mouth

scholarly journals Changing epidemiology of hand, foot, and mouth disease in China, 2013−2019: a population-based study

2022 ◽  
Vol 20 ◽  
pp. 100370
Author(s):  
Jie Hong ◽  
Fengfeng Liu ◽  
Hongchao Qi ◽  
Wei Tu ◽  
Michael P. Ward ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Population Based ◽  
Mouth Disease ◽  
Population Based Study ◽  
Foot And Mouth

STUDY ON CLINICAL CHARACTERISTICS OF HAND FOOT AND MOUTH DISEASE IN HUE CENTRAL HOSPITAL

2014 ◽  
pp. 37-40
Author(s):  
Nu Van Anh Ton ◽  
Din Rmah
Keyword(s):  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Test Method ◽  
Central Hospital ◽  
Cross Sectional ◽  
Study Results ◽  
Foot And Mouth

Objectives: Hand, foot and mouth disease (HFMD) caused by enterovirus, is a common infection in children. HFMD caused by enterovirus 71 can cause some serious complications, such as encephalitis-meningitis, myocarditis, pulmonary edema. The early detection of clinical manifestations of severe contribute to reducing mortality. So aim of this study to describe the clinical characteristics of hand foot and mouth disease in the Department of Pediatrics at Hue Central Hospital. Methods: Random sampling of all hospitalized patients from 1/2/2012 to 31/1/2013 diagnosed HFMD accompanied EV71 serum test. Method of cross-sectional descriptive study. Results and conclusions: with 441 patients admitted Hue Pediatrics Centre, 41,0% cause by EV71 and 59,0% cause by other enterovirus. 97,5% are under 5 years, male/female is 1,15/1. 68,5% coutryside. Almost patients admitted in 2rd and 3rd day (57.1%). Hospitalized reasons are fever (95,5%) and erythema rash. Majority of patients are grade 1 and 2a (87.3%). Grade 3 and 4 only (4.5%). Erythema higher proportion of vesicle, rash on foot is common.

scholarly journals Epidemiology and clinical characteristics of hand foot, and mouth disease in a Shenzhen sentinel hospital from 2009 to 2011

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Yan-rong Wang ◽  
Lu-lu Sun ◽  
Wan-ling Xiao ◽  
Li-yun Chen ◽  
Xian-feng Wang ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Epidemiological and clinical characteristics of children who died from hand, foot and mouth disease in Vietnam, 2011

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Ngoc TB Nguyen ◽  
Hau V Pham ◽  
Cuong Q Hoang ◽  
Tien M Nguyen ◽  
Long T Nguyen ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Surveillance for Enteroviruses Associated with Hand, Foot, and Mouth Disease, and Other Mucocutaneous Symptoms in Spain, 2006–2020

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 781
Author(s):  
Nieves Martínez-López ◽  
Carmen Muñoz-Almagro ◽  
Cristian Launes ◽  
Ana Navascués ◽  
Manuel Imaz-Pérez ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Clinical Data ◽  
Clinical Characteristics ◽  
Foot And Mouth Disease ◽  
Neurological Complications ◽  
Mouth Disease ◽  
Asian Countries ◽  
Foot And Mouth ◽  
Mucocutaneous Symptoms

Hand, foot, and mouth disease (HFMD) is a mild illness caused by enteroviruses (EV), although in some Asian countries, large outbreaks have been reported in the last 25 years, with a considerable incidence of neurological complications. This study describes epidemiological and clinical characteristics of EV infections involved in HFMD and other mucocutaneous symptoms from 2006 to 2020 in Spain. EV-positive samples from 368 patients were included. EV species A were identified in 85.1% of those typed EV. Coxsackievirus (CV) A6 was the prevalent serotype (60.9%), followed by EV-A71 (9.9%) and CVA16 (7.7%). Infections affected children (1–6 years old) mainly, and show seasonality with peaks in spring–summer and autumn. Clinical data indicated few cases of atypical HFMD as well as those with neurological complications (associated with the 2016 EV-A71 outbreak). Phylogenetic analysis of CVA6 VP1 sequences showed different sub-clusters circulating from 2010 to present. In conclusion, HFMD or exanthemas case reporting has increased in Spain in recent years, probably associated with an increase in circulation of CVA6, although they did not seem to show greater severity. However, EV surveillance in mucocutaneous manifestations should be improved to identify the emergence of new types or variants causing outbreaks and more severe pathologies.

scholarly journals Population based hospitalization burden of laboratory-confirmed hand, foot and mouth disease caused by multiple enterovirus serotypes in Southern China

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0203792 ◽  
Author(s):  
Shuanbao Yu ◽  
Qiaohong Liao ◽  
Yonghong Zhou ◽  
Shixiong Hu ◽  
Qi Chen ◽  
...  
Keyword(s):  
Southern China ◽  
Foot And Mouth Disease ◽  
Population Based ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Enterovirus Serotypes

scholarly journals Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases

VirusDisease ◽  
2017 ◽  
Vol 28 (4) ◽  
pp. 430-433 ◽  
Author(s):  
Hau Van Pham ◽  
Tuan N. A. Hoang ◽  
Hao T. Duong ◽  
Lan T. Phan ◽  
Uyen T. N. Phan ◽  
...  
Keyword(s):  
Associated Factors ◽  
Clinical Characteristics ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Molecular Epidemiology and Clinical Features of Enteroviruses-Associated Hand, Foot, and Mouth Disease and Herpangina Outbreak in Zunyi, China, 2019

2021 ◽  
Vol 8 ◽  
Author(s):  
Yuanhang Ai ◽  
Weiwei Zhang ◽  
Jie Wu ◽  
Jingzhi Zhang ◽  
Meijing Shen ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Molecular Epidemiology ◽  
Clinical Features ◽  
Clinical Characteristics ◽  
Laboratory Data ◽  
Foot And Mouth Disease ◽  
Severe Infection ◽  
Mouth Disease ◽  
Vp1 Gene ◽  
Foot And Mouth

Background: Hand, foot and mouth disease (HFMD) and herpangina (HA), two of the most common childhood infectious diseases, are associated with enteroviruses (EVs) infection. The aim of this study was to identify the molecular epidemiology of enterovirus causing HFMD/HA in Zunyi, China, during 2019, and to describe the clinical features of the cases.Methods: We collected the information on demographic and clinical characteristics, laboratory data of laboratory-confirmed EVs associated HFMD/HA cases in Zunyi Medical University Third Affiliated Hospital between March 1 and July 31, 2019. EV types were determined by either one-step real time RT-PCR or partial VP1 gene sequencing and sequence alignment. Phylogenetic analysis of CVA6, CVA2, and CVA5 were established based on the partial VP1 gene sequences by neighbor-joining method. Differences in clinical characteristics and laboratory results of the cases were compared among patients infected with the most prevalent EV types.Results: From 1 March to 31 July 2019, 1,377 EVs associated HFMD/HA inpatients were confirmed. Of them, 4 (0.3%, 4/1,377) were EV-A71-associated cases, 84 (6.1%, 84/1,377) were CVA16-associated cases, and 1,289 (93.6%, 1,289/1,377) were non-EV-A71/CVA16-associated cases. Of the randomly selected 372 non-EV-A71/CVA16 cases, EV types have been successfully determined in 273 cases including 166 HFMD and 107 HA cases. For HFMD cases, the three most common types were CVA6 (80.7%, 134/166), CVA2 (5.4%, 9/166) and CVA5 (3.0%, 5/166); similarly, for HA cases, the three most prevalent serotypes were CVA6 (36.5%, 39/107), CVA2 (21.5%, 23/107) and CVA5 (18.7%, 20/107). Phylogenetic analysis showed that subclade D of CVA5, and subclade E of CVA6 and CVA2 were predominant in Zunyi during the outbreak in 2019. Compared with the cases caused by CVA16, the incidence of high fever and severe infection associated with CVA2, CVA5, and CVA6 was higher.Conclusions: The recent HFMD/HA outbreak in Zunyi is due to a larger incidence of CVA6, CVA2, and CVA5. Novel diagnostic reagents and vaccines against these types would be important to monitor and control EV infections.

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