scholarly journals Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the Wakayama spine study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuyu Ishimoto ◽  
Cyrus Cooper ◽  
Georgia Ntani ◽  
Hiroshi Yamada ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
X Rays ◽  
Cross Sectional ◽  
Total Data ◽  
History Of ◽  
Lumbar Spondylolisthesis ◽  
Nested Case Control ◽  
Control Study

Abstract Background To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). Methods The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. Results In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53–93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥4 h/day (OR 2.39, 95% CI 1.08–5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29–9.29) among those aged < 75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking. Conclusions A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

scholarly journals Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings From A Nested Case Control Study Within The Wakayama Spine Study

2019 ◽  
Author(s):  
Yuyu Ishimoto ◽  
Cyrus Cooper ◽  
Georgia Ntani ◽  
Hiroshi Yamada ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
X Rays ◽  
Cross Sectional ◽  
Total Data ◽  
History Of ◽  
Lumbar Spondylolisthesis ◽  
Nested Case Control ◽  
Control Study

Abstract Background: To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). Methods: The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. Results: In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥ 4 hours/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged <75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking. Conclusions: A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

scholarly journals Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the wakayama spine study

2019 ◽  
Author(s):  
Yuyu Ishimoto ◽  
Cyrus Cooper ◽  
Georgia Ntani ◽  
Hiroshi Yamada ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
X Rays ◽  
Cross Sectional ◽  
Total Data ◽  
History Of ◽  
Lumbar Spondylolisthesis ◽  
Nested Case Control ◽  
Control Study

Abstract Abstract Background: To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). Methods: The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. Results: In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥ 4 hours/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged <75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking. Conclusions: A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

scholarly journals Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the Wakayama spine study

2019 ◽  
Author(s):  
Yuyu Ishimoto ◽  
Cyrus Cooper ◽  
Georgia Ntani ◽  
Hiroshi Yamada ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
X Rays ◽  
Cross Sectional ◽  
Total Data ◽  
History Of ◽  
Lumbar Spondylolisthesis ◽  
Nested Case Control ◽  
Control Study

Abstract Background: To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). Methods: The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. Results: In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥ 4 hours/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged <75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking. Conclusions: A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

scholarly journals IS RADIOGRAPHIC LUMBAR SPONDYLOLISTHESIS ASSOCIATED WITH OCCUPATIONAL EXPOSURES? FINDINGS FROM A NESTED CASE CONTROL STUDY WITHIN THE WAKAYAMA SPINE STUDY

2019 ◽  
Author(s):  
Yuyu Ishimoto ◽  
Cyrus Cooper ◽  
Georgia Ntani ◽  
Hiroshi Yamada ◽  
Hiroshi Hashizume ◽  
...  
Keyword(s):  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
X Rays ◽  
Cross Sectional ◽  
Increased Risk ◽  
Total Data ◽  
Lumbar Spondylolisthesis ◽  
Nested Case Control ◽  
Control Study

Abstract Objective To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). Design The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. Results In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, occupational driving ≥ 2hours/day was associated with a doubling of the risk of being a case (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, working in the agricultural/ fishing industries was associated with a greater than 3-fold increased risk of spondylolisthesis (OR 3.47, 95% CI 1.29-9.29) among those aged <75 years. Climbing slopes/steps and walking were associated with reduced odds ratios. Conclusions A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

scholarly journals Risk of neurodegenerative dementia in asthma patients: a nested case–control study using a national sample cohort

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e030227 ◽  
Author(s):  
So Young Kim ◽  
Chanyang Min ◽  
Dong Jun Oh ◽  
Hyo Geun Choi
Keyword(s):  
Case Control Study ◽  
Previous History ◽  
National Sample ◽  
Case Control ◽  
Region Of Residence ◽  
Neurodegenerative Dementia ◽  
Icd 10 ◽  
History Of ◽  
Nested Case Control ◽  
Control Study

ObjectivesThis study investigated the risk of neurodegenerative dementia following asthma.DesignA nested case–control studySettingThe ≥60-year-old population was selected from the Korean Health Insurance Review and Assessment Service – National Sample Cohort from 2002 to 2013.Participants and interventionsThe 11 442 dementia cases were matched with 45 768 control cases for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Asthma was classified using International Classification of Disease-10 (ICD-10) codes (J45 and J46) and medication history. Dementia was identified based on ICD-10 codes (G30 and F00).Primary and secondary outcome measuresThe ORs of a previous history of asthma in patients with dementia were analysed using conditional logistic regression analysis stratified for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Subgroup analysis was performed according to age and sex.ResultsOverall, 22.6% (2587/11 442) and 22.3% (10 229/45 768) of the cases in the dementia and control groups, respectively, had a previous history of asthma. The OR for asthma in the dementia group was not higher than that in the control group (adjusted OR=0.97, 95% CI 0.92 to 1.02, p=0.207). All age and sex subgroups demonstrated consistent results.ConclusionsAsthma was not related to an increased risk of dementia.

scholarly journals Viral Load in the Natural History of Human Papillomavirus Type 16 Infection: A Nested Case–Control Study

2011 ◽  
Vol 203 (10) ◽  
pp. 1425-1433 ◽  
Author(s):  
Long Fu Xi ◽  
James P. Hughes ◽  
Philip E. Castle ◽  
Zoe R. Edelstein ◽  
Chunhui Wang ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Viral Load ◽  
Natural History ◽  
Case Control Study ◽  
Case Control ◽  
Human Papillomavirus Type 16 ◽  
History Of ◽  
Nested Case Control ◽  
Control Study

scholarly journals The association between SARS-CoV-2 infection and neuronal damage: A population-based nested case-control study

2021 ◽  
Author(s):  
N. Ahmad Aziz ◽  
Marina L.S. Santos ◽  
Monique M.B. Breteler
Keyword(s):  
Plasma Levels ◽  
Case Control Study ◽  
Case Control ◽  
Elisa Test ◽  
Neurological Symptoms ◽  
Batch Effects ◽  
Cross Sectional ◽  
Nested Case Control ◽  
Test Result ◽  
Control Study

Objective: To assess whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with changes in plasma levels of neurofilament light chain (NfL), an extremely sensitive marker of neuroaxonal damage, in community-dwelling individuals. Setting: This study was embedded within the Rhineland Study, an ongoing community-based cohort study in Bonn, Germany Design: Cross-sectional nested case-control study. Participants: Participants were selected based on results from a previously conducted seroprevalence survey within the framework of the Rhineland Study. Cases were defined as those individuals who had had two positive confirmatory test results, including a recombinant spike-based immunofluorescence assay and a plaque reduction neutralization test (N=21). As controls, a random sample of individuals with a negative ELISA test result (Controls I, N=1117), and those with a borderline or positive ELISA test result who failed confirmatory testing (Controls II, N=68), were selected. Outcome measures: Plasma levels of NfL at the time of measurement, as well as change in plasma NfL levels compared to previously measured pre-pandemic levels Results: After adjustment for age, sex and batch effects, serologically confirmed SARS-CoV-2 infection was neither associated with cross-sectional NfL levels, nor with the magnitude of change from pre-pandemic levels, compared to either of the two control groups. Similarly, after adjustment for age, sex and batch effects, self-reported neurological symptoms (including altered sense of smell or taste, headache, myalgia and fever) were not associated with changes in NfL levels in participants with a serologically confirmed SARS-CoV-2 infection (all p ≥ 0.56). Conclusions: Our findings indicate that mild-to-moderate coronavirus disease-19 is unlikely to be associated with a clinically relevant degree of neuroaxonal damage, even in those cases associated with neurological symptoms.

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