scholarly journals Strategies for managing the destruction of calcar femorale

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jin Mei ◽  
Lili Pang ◽  
Zhongchao Jiang
Keyword(s):  
Proximal Femur ◽  
Bone Tumors ◽  
Bone Cyst ◽  
Treatment Strategies ◽  
Femoral Neck Fractures ◽  
Anatomical Structure ◽  
Pathological Fractures ◽  
Main Text ◽  
Primary Bone Tumors ◽  
Primary Bone

Abstract Background The calcar femorale was identified long ago. However, our current understanding of the calcar is insufficient, and its related concepts are sometimes confused. The calcar femoral is an important anatomical structure of the proximal femur, and its function can be overlooked. In trauma, tumors, or other diseases, the calcar femorale can be destroyed or changed pathologically. As a result, the mechanical structure of the proximal femur becomes destroyed, causing pathological fractures. How to address the destruction of the calcar femorale or the damage to the calcar femorale is discussed in this article. Main text Destruction of the calcar femorale is accompanied by many conditions, including trauma, tumors, and other diseases. The types of hip fractures caused by trauma include femoral neck fractures and intertrochanteric fractures. Dynamic hip screws, proximal femoral nail anti-rotation, and multiple parallel cannulate pins can be used in different conditions. When metastatic and primary bone tumors involve the calcar femorale, endoprostheses are widely used. Other diseases, such as fibrous dysplasia and aneurysmal bone cyst are treated differently. Conclusions The calcar femorale can redistribute stresses and the destruction of the calcar femorale can lead to an increase in posterior medial stress. Many factors need to be considered when deciding whether to reconstruct the calcar femorale. Effective treatment strategies for managing the destruction of calcar femorale will need first establishing the precise mechanism of the destruction of the calcar and then designing therapies towards these mechanisms. Further investigation to the calcar needs to be carried out.

Oncological and Functional Outcomes in Joint-sparing Resections of the Proximal Femur for Malignant Primary Bone Tumors

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Dipak B. Ramkumar ◽  
Sean P. Kelly ◽  
Niveditta Ramkumar ◽  
Lisa B. Ercolano ◽  
Santiago Lozano-Calderon ◽  
...  
Keyword(s):  
Proximal Femur ◽  
Functional Outcomes ◽  
Bone Tumors ◽  
Primary Bone Tumors ◽  
Primary Bone

scholarly journals Proximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases

2021 ◽  
Author(s):  
Victor Housset ◽  
Philippe Anract ◽  
Antoine Babinet ◽  
Guillaume Auberger ◽  
David Biau
Keyword(s):  
Hip Joint ◽  
Proximal Femur ◽  
Bone Tumors ◽  
Malignant Bone Tumors ◽  
Primary Bone Tumors ◽  
Comparative Review ◽  
Primary Bone ◽  
The Mean ◽  
Cumulative Probabilities

Abstract Introduction Extra-articular resection (EAR) of the hip joint is prone to significant complications and morbidity. Thus, this study evaluates the cumulative incidences and main reasons of reoperation following EAR of primary bone tumors of the hip to determine whether the outcomes are different between EAR of the pelvis and that of the proximal femur. Patients and methods Thirty-three patients presented with a PMBT of the proximal femur or pelvis were included in this study. Among all PMBTs, 58% originated from the pelvis and 42% were from the proximal femur. Twenty patients had chondrosarcomas (61%), 10 had osteosarcomas (30%), and 3 had sarcomas of another histological subtype (9%). Results The mean follow-up was of 76 months (range: 24–220 months). The cumulative probabilities of revision for any reason was 52% (95% confidence interval [CI]: 30%–70%) five years after surgery. The five-year cumulative probabilities of revision were 13% (95% CI: 4%–27%), 24% (95% CI: 10%–42%) and 34% (95% CI: 14%–56%) for mechanical, infectious and tumoral reasons, respectively. The five-year cumulative probabilities of revision for any reason were 78% (95% CI: 37%–94%) and 14% (95% CI: 2%–38%) for the pelvis and proximal femur, respectively ( p = 0.004). Posterior column preservation was significantly associated with more mechanical complications even after adjusting for the resection site ( p = 0.043). Conclusion Half of patients undergoing EAR of the hip joint for PMBT of the proximal femur or acetabulum will require another operation. EAR of the pelvis is associated with significantly worse outcome than EAR of the proximal femur.

scholarly journals Aneurysmal bone cyst arising in iliopubic chondromyxoid fibroma – a case report

2021 ◽  
Vol 5 (2) ◽  
pp. 10-14
Author(s):  
João Soares do Vale ◽  
◽  
Sara Diniz ◽  
Filipe Rodrigues ◽  
◽  
...  
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Bone Tumors ◽  
Bone Cyst ◽  
Bone Cysts ◽  
Chondromyxoid Fibroma ◽  
Primary Bone Tumors ◽  
Rare Association ◽  
Cartilaginous Tumor ◽  
Aneurysmal Bone Cysts ◽  
Primary Bone

Chondromyxoid fibroma is rare cartilaginous tumor, accounting for 0.5% of all primary bone tumors and 2% of benign bone tumors. Areas of aneurysmal bone cysts (ABC) may be found within CMF in 8.6% of cases. A 20-year-old man presents pain due to a mass on iliopubic ramus that was diagnosed as an aneurysmal bone cyst arising from a chondromyxoid fibroma. This case confirms the rare association between aneurysmal bone cyst and chondromyxoid fibroma. Although aneurysmal bone cyst is more frequently associated with highly vascularized tumors, it is important to consider the diagnosis in the presence of chondromyxoid fibroma. Keywords: Chondromyxoid fibroma; scecondary aneurysmal bone cyst; iliopubic ramus

scholarly journals RANKL/RANK/osteoprotegerin system as novel therapeutic target in the treatment of primary bone tumors and osteolytic metastases

2004 ◽  
Vol 12 (2) ◽  
pp. 112-114 ◽  
Author(s):  
Zlatibor Andjelkovic ◽  
Vuka Katic ◽  
Dragan Mihailovic ◽  
Aleksandar Petrovic ◽  
Ivan Bubanovic
Keyword(s):  
Bone Tumors ◽  
Osteoclast Differentiation ◽  
Treatment Strategies ◽  
Osteoclast Formation ◽  
Skeletal Metastases ◽  
Bone Homeostasis ◽  
Primary Bone Tumors ◽  
Receptor Activator ◽  
Primary Bone ◽  
Nf Kappab

Primary bone tumors and cancers that metastasize to bone require osteoclastic activity to release tumor-supportive growth factors from bone tissue. A number of systemic and locally acting factors are known to influence osteoclast formation, fusion, activation, and survival. Recently, two critical extracellular regulators of osteoclast differentiation and activation have been identified: receptor activator of nuclear factor (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG). RANKL is a tumor necrosis factor (TNF)-related cytokine that stimulates osteoclast differentiation from hematopoietic precursor cells and activation of mature osteoclasts. RANKL activates its specific receptor, receptor activator of NF- kappaB (RANK), located on osteoclasts, chondrocytes and dendritic cells. Binding of the RANK ligand to its receptor and osteoclastogenesis are prevented by osteoprotegerin, a decoy receptor produced by osteoblasts and marrow stromal cells. The balance between RANKL and OPG is of major importance in bone homeostasis. Disorders of the RANKL/RANK/OPG system have been linked to several human diseases, including primary bone tumors skeletal metastases, and hypercalcemia of malignancy. The discovery and characterization of RANKL, RANK and OPG and subsequent studies have changed the concepts of bone metabolism and may form the basis of innovative therapeutic strategies. Novel treatment strategies for bone tumors are emerging based on blockade of the RANKL/RANK interaction. The advantage of these strategies is their potential to selectively target tumor cells. Combining these new strategies with currently available treatments such as chemotherapy and radiation therapy is under investigation, with promising results.

Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

1982 ◽  
Vol 21 (04) ◽  
pp. 136-139 ◽  
Author(s):  
C.-J. Edeling
Keyword(s):  
Soft Tissue ◽  
Bone Scintigraphy ◽  
Primary Tumor ◽  
Bone Tumors ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Malignant Bone Tumors ◽  
67Ga Scintigraphy ◽  
Primary Bone Tumors ◽  
Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

CRYOSURGERY IN THE TREATMENT OF PATIENTS WITH BONE TUMORS

2019 ◽  
Vol 65 (2) ◽  
pp. 165-171
Author(s):  
Aleksey Belyaev ◽  
Georgiy Prokhorov ◽  
Anna Arkhitskaya
Keyword(s):  
Liquid Nitrogen ◽  
Bone Tumors ◽  
Cryogenic Treatment ◽  
Long Term Results ◽  
Bone Lesions ◽  
Giant Cell Tumors ◽  
Primary Bone Tumors ◽  
Circulation Circuit ◽  
Recent Emergence ◽  
Primary Bone

A review of the literature shows that surgical procedures will remain the standard treatment for primary bone tumors. Analysis of studies on the assessment of long-term results shows that additional double cryogenic treatment of the curettage cavity can improve the treatment outcomes of patients with giant cell tumors, dysplastic diseases and some forms of malignant lesions. The traditional execution of the procedure is associated with the open installation of liquid nitrogen in the bone cavity, which requires special skills in handling aggressive refrigerant from the staff and does not exclude complications. In case of multiple metastatic bone lesions, surgical treatment is not indicated. The recent emergence in clinical practice of new equipment with a closed liquid nitrogen circulation circuit inside cryoprobes resumes interest in cryoabla-tion of bone tumor lesions using modern minimally invasive puncture cryotechnology and expanding indications for its use in patients with severe comorbidities.

Wide Surgery in the Cervical Spine: Indications, Results, and Complications in a Series of 30 Patients Affected by Primary Bone Tumors

2021 ◽  
Author(s):  
Alessandro Luzzati ◽  
Gennaro Maria Scotto ◽  
Luca Cannavò ◽  
Giuseppe Orlando ◽  
Alessandra Scotto di Uccio ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Bone Tumors ◽  
Primary Bone Tumors ◽  
Primary Bone
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