Clustering of patients with overactive bladder syndrome

Abstract Background Overactive bladder is a heterogenous condition with poorly characterized clinical phenotypes. To discover potential patient subtypes in patients with overactive bladder (OAB), we used consensus clustering of their urinary symptoms and other non-urologic factors. Methods Clinical variables included in the k-means consensus clustering included OAB symptoms, urinary incontinence, anxiety, depression, psychological stress, somatic symptom burden, reported childhood traumatic exposure, and bladder pain. Results 48 OAB patients seeking care of their symptoms were included. k-means consensus clustering identified two clusters of OAB patients: a urinary cluster and a systemic cluster. The systemic cluster, which consisted of about half of the cohort (48%), was characterized by significantly higher psychosocial burden of anxiety (HADS-A, 9.5 vs. 3.7, p < 0.001), depression (HADS-D, 6.9 vs. 3.6, p < 0.001), psychological stress (PSS, 21.4 vs. 12.9, p < 0.001), somatic symptom burden (PSPS-Q, 28.0 vs. 7.5, p < 0.001), and reported exposure to traumatic stress as a child (CTES, 17.0 vs. 5.4, p < 0.001), compared to the urinary cluster. The systemic cluster also reported more intense bladder pain (3.3 vs. 0.8, p = 0.002), more widespread distribution of pain (34.8% vs. 4.0%, p = 0.009). The systemic cluster had worse urinary incontinence (ICIQ-UI, 14.0 vs. 10.7, p = 0.028) and quality of life (SF-36, 43.7 vs. 74.6, p < 0.001). The two clusters were indistinguishable by their urgency symptoms (ICIQ-OAB, OAB-q, IUSS, 0–10 ratings). The two OAB clusters were different from patients with IC/BPS (worse urgency incontinence and less pain). Conclusions The OAB population is heterogeneous and symptom-based clustering has identified two clusters of OAB patients (a systemic cluster vs. a bladder cluster). Understanding the pathophysiology of OAB subtypes may facilitate treatments.

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The Incidence of Overactive Bladder (OAB) in KIA Poly Patients at Pauh Health Center in Padang City Using Overactive Bladder Symptoms Score (OABSS)

JOURNAL OBGIN EMAS ◽

10.25077/aogj.3.2.55-62.2019 ◽

2019 ◽

Vol 3 (2) ◽

pp. 55-62

Author(s):

Bobby Indra Utama ◽

Widayat Widayat ◽

Berriandi Arwan

Keyword(s):

Urinary Incontinence ◽

Overactive Bladder ◽

Health Center ◽

Sampling Technique ◽

Reproductive Age ◽

Exclusion Criteria ◽

Symptom Scores ◽

Bladder Symptom ◽

Bladder Symptoms ◽

Tract Infections

Objective : This study looked at the incidence of overactive bladder (OAB) in KIA poly patients at Pauh Health Center in Padang City using Overactive Bladder Symptomps Score (OABSS).Method : This research is descriptive. The sampling technique was purposive sampling by considering inclusion and exclusion criteria. The inclusion criteria were women of ideal reproductive age (20-35 years) who had given birth spontaneously, were not pregnant, did not suffer from neurological disorders, diabetes, post bladder surgery and or urinary tract infections and were not treated with Overactive Bladder (OAB), while the exclusion criteria are not willing to take part in the study. The study was carried out at the KIA Poly of Pauh City Health Center in Padang during January 2019. The variable in this study was Overactive Bladder (OAB).Result : In this study, 97.22% of respondents experienced complaints of overactive bladder (OAB), (97.14%) experienced an urgent complaint, and only a small percentage (2.86%) of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Conclusion : Most respondents experienced complaints of overactive bladder (OAB) and urgency, and only a small proportion of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Keywords : overactive bladder (OAB), Urgensi,inkontinensia urin, Overactive Bladder Symptom Scores (OABSS).

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Faculty Opinions recommendation of Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1053869.505810 ◽

2006 ◽

Author(s):

Rodolfo Testa

Keyword(s):

Urinary Incontinence ◽

Overactive Bladder ◽

Receptor Antagonist ◽

Postmenopausal Women ◽

Urge Urinary Incontinence ◽

Efficacy And Safety ◽

Neurokinin 1 Receptor ◽

Neurokinin 1

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Faculty Opinions recommendation of A longitudinal population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in women.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2753962.2417062 ◽

2010 ◽

Author(s):

Apostolos Apostolidis

Keyword(s):

Urinary Incontinence ◽

Urinary Tract ◽

Overactive Bladder ◽

Lower Urinary Tract Symptoms ◽

Lower Urinary Tract ◽

Population Based ◽

Urinary Tract Symptoms ◽

Population Based Survey ◽

Lower Urinary

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Faculty Opinions recommendation of OnabotulinumtoxinA 100 U significantly improves all idiopathic overactive bladder symptoms and quality of life in patients with overactive bladder and urinary incontinence: a randomised, double-blind, placebo-controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718006591.793478312 ◽

2013 ◽

Author(s):

Francisco Cruz

Keyword(s):

Quality Of Life ◽

Urinary Incontinence ◽

Overactive Bladder ◽

Controlled Trial ◽

Double Blind ◽

Double Blind Placebo ◽

Overactive Bladder Symptoms ◽

Bladder Symptoms

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Faculty Opinions recommendation of Feasibility of a Fully Implanted, Nickel Sized and Shaped Tibial Nerve Stimulator for the Treatment of Overactive Bladder Syndrome with Urgency Urinary Incontinence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734714123.793577815 ◽

2020 ◽

Author(s):

Linda Cardozo

Keyword(s):

Urinary Incontinence ◽

Overactive Bladder ◽

Tibial Nerve ◽

Urgency Urinary Incontinence ◽

Overactive Bladder Syndrome ◽

Nerve Stimulator

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Percutaneous versus Transcutaneous Electrical Stimulation of the Posterior Tibial Nerve in Idiopathic Overactive Bladder Syndrome with Urinary Incontinence in Adults: A Systematic Review

Healthcare ◽

10.3390/healthcare9070879 ◽

2021 ◽

Vol 9 (7) ◽

pp. 879

Author(s):

Aida Agost-González ◽

Isabel Escobio-Prieto ◽

Azahara M. Pareja-Leal ◽

María Jesús Casuso-Holgado ◽

María Blanco-Diaz ◽

...

Keyword(s):

Systematic Review ◽

Urinary Incontinence ◽

Electrical Stimulation ◽

Overactive Bladder ◽

Tibial Nerve ◽

Scientific Evidence ◽

Transcutaneous Electrical Stimulation ◽

Posterior Tibial Nerve ◽

Posterior Tibial

Background: Percutaneous electrical stimulation and transcutaneous electrical stimulation (PTNS and TTNS) of the posterior tibial nerve are internationally recognized treatment methods that offer advantages in terms of treating patients with overactive bladder (OAB) who present with urinary incontinence (UI). This article aims to analyze the scientific evidence for the treatment of OAB with UI in adults using PTNS versus TTNS procedures in the posterior tibial nerve. Methods: A systematic review was conducted, between February and May 2021 in the Web of Science and Scopus databases, in accordance with the PRISMA recommendations. Results: The research identified 259 studies, 130 of which were selected and analyzed, with only 19 used according to the inclusion requirements established. The greatest effectiveness, in reducing UI and in other parameters of daily voiding and quality of life, was obtained by combining both techniques with other treatments, pharmacological treatments, or exercise. Conclusions: TTNS has advantages over PTNS as it is more comfortable for the patient even though there is equality of both therapies in the outcome variables. More research studies are necessary in order to obtain clear scientific evidence.

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