scholarly journals Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zezheng Wang ◽  
Shuang Zhang ◽  
Yumei Pu ◽  
Yuxin Wang ◽  
Zitong Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Mean Deviation ◽  
Bone Invasion ◽  
Nerve Invasion

Abstract Background For patients with oral squamous cell carcinoma (OSCC), accurate evaluation of mandible invasion and resection with appropriate boundaries are important for preserving the structure and function of the mandible and preventing local recurrence. Although cone-beam computed tomography (CBCT), which has high spatial resolution, is now widely used in the diagnosis of oral and maxillofacial bone lesions, no studies have systematically evaluated the accuracy of CBCT for evaluating the presence of bone invasion, the boundaries of bone invasion and the presence of nerve invasion. Therefore, this study aimed to systemically explore the accuracy of CBCT in the preoperative assessment of mandibular invasion by OSCC. Methods Thirty mandibular specimens from OSCC patients were collected in this study. The samples were marked and subjected to CBCT examination. Hematoxylin–eosin staining was used for histopathological assessment sed as the gold standard. The evaluation included the presence of bone invasion, the boundaries of bone invasion and the presence of nerve invasion. The CBCT and histopathological boundaries of bone invasion were delineated and merged to compare and calculate the deviation of CBCT in boundary evaluation. Results The accuracy of CBCT in evaluating the presence of mandible invasion was 100%, and the accuracy of CBCT in evaluating the presence of nerve invasion was 69.2%. A mean deviation of 2.97 mm was found for assessment of the boundary of bone invasion using CBCT compared with the histopathological standard. The interexaminer agreement and intraexaminer agreement were perfect for the detection of bone invasion and nerve invasion (κ > 0.8). The intraclass correlation coefficient was 0.923 for the consistency test of boundary delineation on CBCT images. Conclusion CBCT is quite reliable in determining the presence or absence of mandible invasion but not as reliable for nerve invasion. The deviation in bone invasion boundary estimation should be considered in osteotomy for OSCC.

scholarly journals Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma

2020 ◽  
Author(s):  
Zezheng Wang ◽  
Shuang Zhang ◽  
Yumei Pu ◽  
Yuxin Wang ◽  
Zitong Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Mean Deviation ◽  
Bone Invasion ◽  
Nerve Invasion

Abstract Background: Accurate evaluation of mandible invasion and resection with appropriate boundary for oral squamous cell carcinoma (OSCC) are important for preserving structure and function of mandible and preventing local recurrence. Although cone-beam computed tomography (CBCT), which has high spatial resolution, is now widely used in the diagnosis of oral and maxillofacial bone lesions. There were no studies systematically evaluate the accuracy of CBCT for evaluation of presence of bone invasion, boundary of bone invasion and presence of nerve invasion. Therefore, this study aimed to systemically explore the accuracy of CBCT in preoperative assessment of mandibular invasion by OSCC. Methods: Thirty mandibular specimens from OSCC patients were collected in this study. The samples were marked and subjected to CBCT examination. Hematoxylin–eosin staining was used for histopathological assessment and used as golden standard. The evaluation included the presence of bone invasion, boundary of bone invasion and presence of nerve invasion. The CBCT and histopathological boundaries of bone invasion were delineated and merged to compare and calculate the deviation of CBCT in boundary evaluation. Results: The accuracy of CBCT in evaluation of presence of mandible invasion was 100%, and the accuracy of CBCT in evaluation of presence of nerve invasion was 69.2%. A mean deviation of 2.97 mm was found for assessment the boundary of bone invasion using CBCT compared with the histopathological standard. Conclusion: CBCT is quite reliable in determine the presence or absence of mandible invasion, while not so reliable for nerve invasion. The deviation in bone invasion boundary estimation should be considered in the osteotomy for OSCC.

scholarly journals Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma

2020 ◽  
Author(s):  
Zezheng Wang ◽  
Shuang Zhang ◽  
Yumei Pu ◽  
Yuxin Wang ◽  
Zitong Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Bone Invasion ◽  
Nerve Invasion ◽  
Examiner Agreement

Abstract Background: Accurate evaluation of mandible invasion and resection with appropriate boundary for oral squamous cell carcinoma (OSCC) are important for preserving structure and function of mandible and preventing local recurrence. Although cone-beam computed tomography (CBCT), which has high spatial resolution, is now widely used in the diagnosis of oral and maxillofacial bone lesions. There were no studies systematically evaluate the accuracy of CBCT for evaluation of presence of bone invasion, boundary of bone invasion and presence of nerve invasion. Therefore, this study aimed to systemically explore the accuracy of CBCT in preoperative assessment of mandibular invasion by OSCC.Methods: Thirty mandibular specimens from OSCC patients were collected in this study. The samples were marked and subjected to CBCT examination. Hematoxylin–eosin staining was used for histopathological assessment and used as golden standard. The evaluation included the presence of bone invasion, boundary of bone invasion and presence of nerve invasion. The CBCT and histopathological boundaries of bone invasion were delineated and merged to compare and calculate the deviation of CBCT in boundary evaluation. Results: The accuracy of CBCT in evaluation of presence of mandible invasion was 100%, and the accuracy of CBCT in evaluation of presence of nerve invasion was 69.2%. A mean deviation of 2.97 mm was found for assessment the boundary of bone invasion using CBCT compared with the histopathological standard. The inter-examiner agreement and intra-examiner agreement were perfect for the detection of bone invasion and nerve invasion (κ＞0.8). Intraclass Correlation Coefficient was 0.923 for the consistency test of boundary delineation on CBCT image.Conclusion: CBCT is quite reliable in determine the presence or absence of mandible invasion, while not so reliable for nerve invasion. The deviation in bone invasion boundary estimation should be considered in the osteotomy for OSCC.

scholarly journals Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma

2020 ◽  
Author(s):  
Zezheng Wang ◽  
Shuang Zhang ◽  
Yumei Pu ◽  
Yuxin Wang ◽  
Zitong Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Histopathological Examination ◽  
Preoperative Assessment ◽  
Cone Beam ◽  
Nerve Invasion

Abstract Purpose: Surgery for oral cancer with mandibular invasion requires an accurate preoperative assessment. Although cone-beam computed tomography (CBCT), which yields high spatial resolution, is used widely for mandibular examinations, evidence supporting its accuracy for the evaluation of malignant mandibular invasion is insufficient. Therefore, this study aimed to explore the accuracy of CBCT for the preoperative assessment of mandibular invasion. Methods: Thirty mandibular specimens acquired via mandibulectomy for oral squamous cell carcinoma (OSCC) treatment were collected. The excised samples were marked and subjected to CBCT imaging. Hematoxylin–eosin staining was used for histopathological assessment. Mandibular invasion was estimated based on CBCT and pathologic findings. Invasive borders were delineated via histopathological examination and CBCT and merged to compare the extent of invasion. Results: Although CBCT predicted the excised mandible invasion with 100% accuracy, it predicted nerve invasion with only 69.2% accuracy. The bone samples exhibited significant shrinkage (8.9%) due to tissue processing. This bone mass shrinkage led to a tendency of CBCT to underestimate the extent of invasion, with a mean difference of 2.97 mm. Conclusion: CBCT can reliably assess mandibular invasion, but is much less accurate for the estimation of nerve invasion. Given the potential for underestimation of the extent of mandibular invasion, CBCT would be better used to determine the extent of osteotomy.

scholarly journals Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma

2020 ◽  
Author(s):  
Zezheng Wang ◽  
Shuang Zhang ◽  
Yumei Pu ◽  
Yuxin Wang ◽  
Zitong Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Histopathological Examination ◽  
Preoperative Assessment ◽  
Cone Beam ◽  
Nerve Invasion

Abstract Purpose: Surgery for oral cancer with mandibular invasion requires an accurate preoperative assessment. Although cone-beam computed tomography (CBCT), which yields high spatial resolution, is used widely for mandibular examinations, evidence supporting its accuracy for the evaluation of malignant mandibular invasion is insufficient. Therefore, this study aimed to explore the accuracy of CBCT for the preoperative assessment of mandibular invasion.Methods: Thirty mandibular specimens acquired via mandibulectomy for oral squamous cell carcinoma (OSCC) treatment were collected. The excised samples were marked and subjected to CBCT imaging. Hematoxylin–eosin staining was used for histopathological assessment. Mandibular invasion was estimated based on CBCT and pathologic findings. Invasive borders were delineated via histopathological examination and CBCT and merged to compare the extent of invasion.Results: Although CBCT predicted the excised mandible invasion with 100% accuracy, it predicted nerve invasion with only 69.2% accuracy. The bone samples exhibited significant shrinkage (8.9%) due to tissue processing. This bone mass shrinkage led to a tendency of CBCT to underestimate the extent of invasion, with a mean difference of 2.97 mm.Conclusion: CBCT can reliably assess mandibular invasion, but is much less accurate for the estimation of nerve invasion. Given the potential for underestimation of the extent of mandibular invasion, CBCT would be better used to determine the extent of osteotomy.

scholarly journals Cone-Beam Computed Tomography to Assess Mandibular Invasion in Oral Squamous Cell Carcinoma

2018 ◽  
Vol 8 (2) ◽  
pp. 18-22
Author(s):  
Md Ariful Islam ◽  
Md Nasir Uddin ◽  
Md Shahjahan Ali ◽  
Md Mahfuz Hossain
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Positive Predictive Value ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Predictive Value ◽  
Cone Beam ◽  
Sensitivity Specificity

Background: Oral squamous cell carcinoma which occurs closely to the mandible has a tendency to invade mandible. An accurate preoperative evaluation of mandibular invasion is important for optimum treatment planning. Aim of this study is to determine the accuracy of CBCT in detection of mandibular invasion in oral squamous cell carcinoma. Study design: In this prospective observational study 35 patients of histologically proven squamous cell carcinoma which was close proximity to the mandible were selected. The results of preoperative CBCT scan of mandible were compared with that of post operative histopathology of bone and thus sensitivity, specificity, negative predictive value, positive predictive value were calculated. Results: Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CBCT were 96%, 90.90%, 96%, 90.90%, 97.14% respectively (Chi squared with Yates correction equals 21.844 with 1 degrees of freedom, p value < o.oooo1). Conclusion: Cone beam computed tomography is a sensitive test and has an acceptable range of specificity. Update Dent. Coll. j: 2018; 8 (2): 18-22

scholarly journals End of treatment cone-beam computed tomography (CBCT) is predictive of radiation response and overall survival in oropharyngeal squamous cell carcinoma

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Whitney Sumner ◽  
Sangwoo S. Kim ◽  
Lucas Vitzthum ◽  
Kevin Moore ◽  
Todd Atwood ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Image Guidance ◽  
Cone Beam

Abstract Background Image guidance in radiation oncology has resulted in significant improvements in the accuracy and precision of radiation therapy (RT). Recently, the resolution and quality of cone beam computed tomography (CBCT) for image guidance has increased so that tumor masses and lymph nodes are readily detectable and measurable. During treatment of head and neck squamous cell carcinoma (HNSCC), on-board CBCT setup imaging is routinely obtained; however, this CBCT imaging data is not utilized to predict patient outcomes. Here, we analyzed whether changes in CBCT measurements obtained during a course of radiation therapy correlate with responses on routine 3-month follow-up diagnostic imaging and overall survival (OS). Materials/methods Patients with oropharyngeal primary tumors who received radiation therapy between 2015 and 2018 were included. Anatomical measurements were collected of largest nodal conglomerate (LNC) at CT simulation, end of radiation treatment (EOT CBCT), and routine 3-month post-RT imaging. At each timepoint anteroposterior (AP), mediolateral (ML) and craniocaudal (CC) measurements were obtained and used to create a 2-dimensional (2D) maximum. Results CBCT data from 64 node positive patients were analyzed. The largest nodal 2D maximum and CC measurements on EOT CBCT showed a statistically significant correlation with complete response on 3-month post-RT imaging (r = 0.313, p = 0.02 and r = 0.318, p = 0.02, respectively). Furthermore, patients who experienced a 30% or greater reduction in the CC dimension had improved OS (Binary Chi-Square HR 4.85, p = 0.028). Conclusion Decreased size of pathologic lymph nodes measured using CBCT setup imaging during a radiation course correlates with long term therapeutic response and overall survival of HNSCC patients. These results indicate that CBCT setup imaging may have utility as an early predictor of treatment response in oropharyngeal HNSCC.

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