scholarly journals Use of smoking cessation pharmacotherapies during pregnancy is not associated with increased risk of adverse pregnancy outcomes: a population-based cohort study

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Duong Thuy Tran ◽  
David B. Preen ◽  
Kristjana Einarsdottir ◽  
Anna Kemp-Casey ◽  
Deborah Randall ◽  
...  
Author(s):  
Shamil D. Cooray ◽  
Jacqueline A. Boyle ◽  
Georgia Soldatos ◽  
Shakila Thangaratinam ◽  
Helena J. Teede

AbstractGestational diabetes mellitus (GDM) is common and is associated with an increased risk of adverse pregnancy outcomes. However, the prevailing one-size-fits-all approach that treats all women with GDM as having equivalent risk needs revision, given the clinical heterogeneity of GDM, the limitations of a population-based approach to risk, and the need to move beyond a glucocentric focus to address other intersecting risk factors. To address these challenges, we propose using a clinical prediction model for adverse pregnancy outcomes to guide risk-stratified approaches to treatment tailored to the individual needs of women with GDM. This will allow preventative and therapeutic interventions to be delivered to those who will maximally benefit, sparing expense, and harm for those at a lower risk.


2008 ◽  
Vol 193 (4) ◽  
pp. 311-315 ◽  
Author(s):  
Emma Nilsson ◽  
Christina M. Hultman ◽  
Sven Cnattingius ◽  
Petra Otterblad Olausson ◽  
Camilla Björk ◽  
...  

BackgroundWomen with schizophrenia are at increased risk for adverse pregnancy outcomes. It is not known whether offspring born to fathers with schizophrenia also have an increased risk.AimsTo evaluate paternal and maternal influences on the association between schizophrenia and pregnancy outcomes.MethodA record linkage including 2 million births was made using Swedish population-based registers. The risk for adverse pregnancy outcomes was evaluated through logistic regression.ResultsOffspring with a mother or father with schizophrenia faced a doubled risk of infant mortality, which could not be explained by maternal behaviour alone during pregnancy. Excess infant death risk was largely attributable to post-neonatal death. Maternal factors (e.g. smoking) explained most of the other risks of adverse pregnancy outcomes among both mothers and fathers with schizophrenia.ConclusionsThe risks to offspring whose fathers had schizophrenia suggest that, in addition to maternal risk behaviour, nonoptimal social and/or parenting circumstances are of importance.


PLoS Medicine ◽  
2015 ◽  
Vol 12 (7) ◽  
pp. e1001851 ◽  
Author(s):  
Bijaya K. Padhi ◽  
Kelly K. Baker ◽  
Ambarish Dutta ◽  
Oliver Cumming ◽  
Matthew C. Freeman ◽  
...  

Cephalalgia ◽  
2009 ◽  
Vol 30 (4) ◽  
pp. 433-438 ◽  
Author(s):  
H-M Chen ◽  
S-F Chen ◽  
Y-H Chen ◽  
H-C Lin

Using a 3-year nationwide population-based database, this study aims to examine the risk of adverse pregnancy outcomes in women with migraines, including low birthweight (LBW), preterm birth, infants born small for gestational age, Caesarean section (CS) and pre-eclampsia. We identified a total of 4911 women with migraines who gave birth from 2001 to 2003, together with 24 555 matched women as a comparison cohort. Multivariate logistic regression analyses showed that after adjusting for potential confounders, the odds ratios were 1.16 [95% confidence intervals (CI) = 1.03–1.31, P = 0.014] for LBW, 1.24 (95% CI = 1.13–1.39, P < 0.001) for preterm births, 1.16 (95% CI = 1.07–1.24, P < 0.001) for CS and 1.34 (95% CI = 1.02–1.77, P = 0.027) for pre-eclampsia for women with migraines compared with unaffected mothers. We conclude that women with migraines were at increased risk of having LBW, preterm babies, pre-eclampsia and delivery by CS, compared with unaffected mothers.


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