scholarly journals Correction to: Predicting in vivo absorption of chloramphenicol in frogs using in vitro percutaneous absorption data

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Victoria K. Llewelyn ◽  
Lee Berger ◽  
Beverley D. Glass
Keyword(s):  
Percutaneous Absorption ◽  
Absorption Data ◽  
In Vivo Absorption ◽  
In Vitro Percutaneous Absorption

An amendment to this paper has been published and can be accessed via the original article.

Methods for in vitro percutaneous absorption studies I. Comparison with in vivo results

1982 ◽  
Vol 62 (3) ◽  
pp. 474-480 ◽  
Author(s):  
Robert L. Bronaugh ◽  
Raymond F. Stewart ◽  
Elaine R. Congdon ◽  
Albert L. Giles
Keyword(s):  
Percutaneous Absorption ◽  
Absorption Studies ◽  
In Vitro Percutaneous Absorption

Use of Percutaneous Absorption Data in Risk Assessment

1989 ◽  
Vol 8 (5) ◽  
pp. 815-827 ◽  
Author(s):  
C. A. Franklin ◽  
D. A. Somers ◽  
I. Chu
Keyword(s):  
Risk Assessment ◽  
Percutaneous Absorption ◽  
Dermal Absorption ◽  
In Vivo Studies ◽  
Absorption Data ◽  
Regulatory Decision ◽  
Dermal Penetration ◽  
High Doses

Assessment of risks to humans associated with the use of chemicals requires knowledge of the hazard (toxicity) of the chemical and level of human exposure. Hazard assessment is often based on animal bioassays and quantitative exposure estimates of dermal exposure obtained from studies monitoring workers. Because human skin is an effective barrier to many chemicals, it cannot be assumed that the deposited dose is equivalent to the systemic dose. However, an estimate of systemic dose may be derived by multiplying the deposited dose by the percentage of percutaneous uptake. This correction can have major impact on the regulatory decision, because the adjusted dose used in the risk calculation may be reduced significantly, especially at high doses, when the uptake is not linearly proportional to the exposure. It is therefore important that the dermal absorption value be accurate. As outlined in this paper, numerous factors can affect percutaneous absorption. Nevertheless, many regulatory agencies will consider the use of percutaneous absorption data derived from in vivo studies to adjust the dermally deposited dose to that delivered systemically. Numerous issues must be resolved before in vitro dermal penetration studies can be used for risk assessment.

In vivo and in vitro percutaneous absorption of [14C]pyrene in Sprague Dawley male rats: skin reservoir effect and consequence on urinary 1-OH pyrene excretion

2008 ◽  
Vol 82 (10) ◽  
pp. 739-747 ◽  
Author(s):  
Jean-Paul Payan ◽  
Michel Lafontaine ◽  
Patrice Simon ◽  
Fabrice Marquet ◽  
Catherine Champmartin-Gendre ◽  
...  
Keyword(s):  
Percutaneous Absorption ◽  
Male Rats ◽  
Sprague Dawley ◽  
Reservoir Effect ◽  
Skin Reservoir ◽  
In Vitro Percutaneous Absorption

In Vivo and in Vitro Percutaneous Absorption and Skin Decontamination of Arsenic from Water and Soil

1993 ◽  
Vol 20 (3) ◽  
pp. 336-340 ◽  
Author(s):  
RONALD C. WESTER ◽  
HOWARD I. MAIBACH ◽  
LENA SEDIK ◽  
JOSEPH MELENDRES ◽  
MICHAEL WADE
Keyword(s):  
Percutaneous Absorption ◽  
Skin Decontamination ◽  
In Vitro Percutaneous Absorption
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