Acupuncture And Chinese Herb Medicine Yangjing Zhongyu Decoction For The Treatment of Endometriosis-Associated Infertility: A Study Protocol For A Multi-Center, Controlled and Randomized Clinical Trial

Introduction: Endometriosis is an inflammatory estrogen-dependent gynecological disease, which is one of the common reasons for infertility. The current treatments of endometriosis-associated infertility often involve laparoscopic surgery, medical therapy and in vitro fertilization (IVF) therapy, which are expensive, and the therapeutic effects are far from the expectation. Acupuncture and Yangjing Zhongyu Decoction (YZD) which have the advantages of effective and inexpensive, have been used clinically for the infertile female in China for many years. However, a comprehensive evaluation of the current clinical evidence of their efficacy is lacking. Our study intends to evaluate the efficacy of acupuncture and YZD on endometriosis-associated infertility (EAI).Methods/design: This study is a multi-center, controlled and randomized clinical trial. A total of 224 eligible patients with endometriosis-associated infertility will be randomly assigned into two groups, in a 1:1 ratio as the treatment group or the control group. All participants will receive pregnancy guidance. The participants assigned to the treatment group will be treated with acupuncture and YZD while the control group will receive the GnRH-a therapy. The trial will include three menstrual cycles of treatment and twelve menstrual cycles of follow-up. The primary outcome is pregnancy rate that will be verified by human chorionic gonadotropin (HCG) tests and secondary outcomes include the result of ultrasound, cancer antigen 125 (CA125), anti-Müllerian hormone (AMH), sex hormones, alanine aminotransferase (ALT) and the Endometriosis Health Profile-5 (EHP-5). Outcome will be collected at baseline, the end of treatments and follow-up visits at 3, 6 and 12 menstrual cycles. All the data including the major adverse events will be recorded in electronic case report forms and analysed by SPSS V.25.0.Discussion: This study protocol will help to evaluate whether acupuncture and Chinese herb medicine Yangjing Zhongyu Decoction are effective in increasing pregnancy rate of the infertile female with endometriosis.Trial registration: ChiCTR2100042830; Registered on 29 January 2021.

Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling

Saponins derived from Panax notoginseng root are widely used as herb medicine and dietary supplements due to their wide range of health benefits. However, the effects of those from Panax...

Antihyperlipidemic Effect of Ethanol Extract of Lansau a Traditional Medicine of Muna Ethnic, Indonesia

Lansau is a traditional herb medicine from Muna ethnic, Southeast Sulawesi, Indonesia, consisting of 44 medicinal plants. This study was performed to determine and evaluate the antihyperlipidemic effect of ethanol extract of Lansau in high cholesterol and propylthiouracil induced hyperlipidemic rats. The animal test Wistar strain were used and divided into six groups namely KN (Na. CMC 1%), K (-) (Na CMC 1% + MDLT), K (+) (simvastatin 0.40 mg/kg BW), LS I (Lansau ethanol extract 6.907 mg/kg BW), LS II (ethanol extract Lansau 13.814 mg/kg BW) and LS III (Lansau LS III ethanol extract 27.628 mg/kg BW. The results showed that ethanol extract of traditional Lansau medicine with dose LS I 6.907 mg/kg BW, LS II 27.628 mg/kg BW and LS III 27.628 mg/kg BW have significant activity as antihyperlipidemic (cholesterol and triglyceride) compared to negative control groups (p <0.05) and showed the same activity with simvastatin in lowering total cholesterol and triglyceride levels (p> 0.05), which shows its potential as antihyperlipidemic herbal medicine.