scholarly journals The dysregulated expression and functional effect of CaMK2 in cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qi He ◽  
Zhenyu Li
Keyword(s):  
Protein Kinase ◽  
Cancer Progression ◽  
Therapeutic Strategy ◽  
Altered Expression ◽  
Cellular Processes ◽  
Calcium Calmodulin Dependent ◽  
Specific Effects ◽  
Dependent Protein ◽  
Proliferation And Metastasis

AbstractCaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca2+ signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However, the specific effects of CaMK2 on cancer have not been fully elucidated. In this review, we summarize not only the altered expression of CaMK2 in a range of cancers, as evidenced by bioinformatics analysis, but also the significant role of CaMK2 in regulating cancer progression, such as proliferation and metastasis. In addition, we described the functional influence of CaMK2 on cancer stemness and resistance. Understanding the critical effects and mechanisms of CaMK2 in cancer would facilitate the development of a promising therapeutic strategy for cancer treatment.

scholarly journals An Overview of the Role of Calcium/Calmodulin-Dependent Protein Kinase in Cardiorenal Syndrome

2020 ◽  
Vol 11 ◽  
Author(s):  
Carolina Victoria Cruz Junho ◽  
Wellington Caio-Silva ◽  
Mayra Trentin-Sonoda ◽  
Marcela Sorelli Carneiro-Ramos
Keyword(s):  
Protein Kinase ◽  
Cardiorenal Syndrome ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Dependent Protein

Role of Calcium-Calmodulin–Dependent Protein Kinase II in Modulation of Sensorimotor Synapses in Aplysia

1997 ◽  
Vol 78 (1) ◽  
pp. 409-416 ◽  
Author(s):  
Keiko Nakanishi ◽  
Fan Zhang ◽  
Douglas A. Baxter ◽  
Arnold Eskin ◽  
John H. Byrne
Keyword(s):  
Protein Kinase ◽  
Sensory Neuron ◽  
Action Potentials ◽  
Short Term ◽  
Dependent Protein Kinase ◽  
Duration Of Action ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein

Nakanishi, Keiko, Fan Zhang, Douglas A. Baxter, Arnold Eskin, and John H. Byrne. Role of calcium-calmodulin–dependent protein kinase II in modulation of sensorimotor synapses in Aplysia. J. Neurophysiol. 78: 409–416, 1997. The Ca2+-calmodulin–dependent protein kinase II (CaMKII) inhibitor, {1-[N,O - bis(5 - isoquinolinesulfonyl) - N - methyl - L - tyrosyl] - 4 - phenylpiper azine} (KN-62), was used to investigate the role of CaMKII in synaptic transmission and serotonin (5-HT)-induced facilitation in Aplysia. Application of KN-62 (10 μM) by itself increased the amplitude of excitatory postsynaptic potentials (EPSPs) at sensorimotor synapses in pleural-pedal ganglia. Moreover, in the presence of KN-62, 5-HT–induced short-term facilitation was attenuated. Application of KN-62 by itself slightly increased the duration of action potentials in isolated sensory neuron somata but did not block spike broadening produced by 5-HT. KN-62 had no effect on excitability of isolated sensory neuron somata nor did it block 5-HT–induced enhancement of excitability. These results indicate that the attenuation of short-term facilitation by KN- 62 is not due to modulation of the membrane currents contributing to 5-HT–induced spike broadening or enhancement of excitability. Rather, these data are consistent with the hypothesis that CaMKII contributes to the regulation of sensorimotor connections and that it has a role in spike-duration–independent processes contributing to short-term facilitation.

scholarly journals Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy

2021 ◽  
Vol 11 ◽  
Author(s):  
Die Lv ◽  
Hongli Chen ◽  
Yun Feng ◽  
Bomiao Cui ◽  
Yingzhu Kang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Small Molecule ◽  
Therapeutic Strategy ◽  
Protein Kinase D ◽  
Successful Development ◽  
Cellular Processes ◽  
The Past ◽  
Calcium Calmodulin Dependent ◽  
Pathological Conditions ◽  
Molecule Inhibitor

The protein kinase D (PKD) family is a family of serine-threonine kinases that are members of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been increasingly implicated in multiple pivotal cellular processes and pathological conditions. PKD dysregulation is associated with several diseases, including cancer, inflammation, and obesity. Over the past few years, small-molecule inhibitors have emerged as alternative targeted therapy with fewer adverse side effects than currently available chemotherapy, and these specifically targeted inhibitors limit non-specific toxicities. The successful development of PKD inhibitors would significantly suppress the growth and proliferation of various cancers and inhibit the progression of other diseases. Various PKD inhibitors have been studied in the preclinical setting. In this context, we summarize the PKD inhibitors under investigation and their application for different kinds of diseases.

The role of calcium/calmodulin-dependent protein kinase cascade on MIP-1α gene expression of ATL cells

2008 ◽  
Vol 36 (4) ◽  
pp. 390-400 ◽  
Author(s):  
Kensuke Matsumoto ◽  
Koji Murao ◽  
Hitomi Imachi ◽  
Takamasa Nishiuchi ◽  
Wenming Cao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Kinase Cascade ◽  
Dependent Protein ◽  
Protein Kinase Cascade
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