scholarly journals Neuroactivity of detonation nanodiamonds: dose-dependent changes in transporter-mediated uptake and ambient level of excitatory/inhibitory neurotransmitters in brain nerve terminals

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Natalia Pozdnyakova ◽  
Artem Pastukhov ◽  
Marina Dudarenko ◽  
Maxim Galkin ◽  
Arsenii Borysov ◽  
...  
Keyword(s):  
Detonation Nanodiamonds ◽  
Nerve Terminals ◽  
Inhibitory Neurotransmitters ◽  
Ambient Level ◽  
Brain Nerve Terminals ◽  
Dose Dependent

Effects of new fluorinated analogues of GABA, pregabalin bioisosters, on the ambient level and exocytotic release of [3H]GABA from rat brain nerve terminals

2017 ◽  
Vol 25 (2) ◽  
pp. 759-764 ◽  
Author(s):  
T. Borisova ◽  
N. Pozdnyakova ◽  
E. Shaitanova ◽  
I. Gerus ◽  
M. Dudarenko ◽  
...  
Keyword(s):  
Rat Brain ◽  
Nerve Terminals ◽  
Ambient Level ◽  
Brain Nerve Terminals

Amitriptyline and imipramine inhibit the release of acetylcholine from parasympathetic nerve terminals in the rat iris

1984 ◽  
Vol 62 (7) ◽  
pp. 857-859 ◽  
Author(s):  
J. S. Richardson ◽  
T. G. Mattio ◽  
E. Giacobini
Keyword(s):  
Nerve Terminals ◽  
Dependent Manner ◽  
Parasympathetic Nerve ◽  
Drug Concentrations ◽  
Release Of Acetylcholine ◽  
Rat Iris ◽  
Anticholinergic Side Effects ◽  
Dose Dependent ◽  
Drug Free

The electrically stimulated release of [3H]acetylcholine from the parasympathetic nerve terminals of the rat iris in vitro is increased in a dose-dependent manner by scopolamine but is decreased by the tricyclic antidepressants amitriptyline and imipramine. The increased release in the presence of scopolamine seems to be due to the blockade of a presynaptic muscarinic autoreceptor that, in the drug-free state, inhibits the release of acetylcholine. However, at drug concentrations that should have comparable antimuscarinic potency, the antidepressants inhibit the release of acetylcholine. This suggests that the anticholinergic side effects of the antidepressants may be due to the reduced release of acetylcholine from parasympathetic nerve terminals as well as a possible direct postsynaptic muscarinic receptor blocking action. Whatever the mechanism of this action, the antidepressants do not have the same effect as scopolamine at the presynaptic muscarinic autoreceptor in the rat iris.

Monitoring of the velocity of high-affinity glutamate uptake by isolated brain nerve terminals using amperometric glutamate biosensor

Talanta ◽  
2015 ◽  
Vol 135 ◽  
pp. 67-74 ◽  
Author(s):  
O. Soldatkin ◽  
A. Nazarova ◽  
N. Krisanova ◽  
A. Borуsov ◽  
D. Kucherenko ◽  
...  
Keyword(s):  
Glutamate Uptake ◽  
Nerve Terminals ◽  
High Affinity ◽  
Brain Nerve Terminals

scholarly journals OPTIMIZATION OF AMPEROMETRIC BIOSENSOR FOR EVALUATION OF RATE OF GLUTAMATE UPTAKE BY ISOLATED BRAIN NERVE TERMINALS

2016 ◽  
Vol 13 (1) ◽  
pp. 98
Author(s):  
Д. Ю. Кучеренко ◽  
І. С. Кучеренко ◽  
Д. В. Седюко ◽  
Д. В. Книжникова ◽  
О. О. Солдаткін ◽  
...  
Keyword(s):  
Glutamate Uptake ◽  
Amperometric Biosensor ◽  
Nerve Terminals ◽  
Brain Nerve Terminals
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