scholarly journals Lung metastases from intraductal papillary neoplasm of the bile duct: a case report

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Rika Fujino ◽  
Yoshihito Masuoka ◽  
Taro Mashiko ◽  
Akira Nakano ◽  
Kenichi Hirabayashi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bile Duct ◽  
Lung Metastases ◽  
Tumor Resection ◽  
World Health ◽  
Resected Specimen ◽  
Pathological Findings ◽  
Liver Recurrence ◽  
Intraductal Papillary Neoplasm ◽  
Papillary Neoplasm

Abstract Background Intraductal papillary neoplasm of the bile duct (IPNB) is considered a pre-cancerous biliary lesion and/or an early cancer lesion, although its classification remains unclear. The 2019 revised edition of the World Health Organization Classification of Tumors of the Digestive System proposed type 1 and type 2 as new classification categories, and meta-analyses and/or multi-center cohort studies are beginning to be reported. However, treatment for IPNB recurrence and metastasis remains unclear. Case presentation A 60-year-old man who was referred to our hospital after a suspected liver tumor was diagnosed using abdominal ultrasonography. Imaging findings revealed an irregularly shaped tumor in segment 5 (S5) of the liver (size 20 mm). The S5 lesion was suspected as IPNB, and segmentectomy was performed. The pathological findings revealed invasive carcinoma derived from IPNB, and immunohistochemistry revealed positive expression of MUC1, MUC5AC, and MUC6, but negative expression of CDX2 and MUC2. At 9 months after the surgery, computed tomography revealed a tumor in the right bile duct, which was diagnosed as liver recurrence of IPNB, and right hepatectomy was performed. The histopathological findings were the same as for the first resected specimen (i.e., IPNB). At 45 months after the second surgery, computed tomography revealed nodules in both lungs, which were diagnosed as lung metastases from IPNB and resected in two separate procedures. The pathological findings were metastatic carcinoma from IPNB for both lung lesions. The patient is currently alive and undergoing adjuvant chemotherapy (S-1), which was initiated 64 months after the first resection and 12 months after resection of the lung metastases. Conclusion We encountered a rare case of lung metastases from IPNB, which were diagnosed immunohistologically. Because IPNB is generally a slow-growing tumor, resection may be feasible for IPNB recurrence and/or metastasis, which may be detected during long-term follow-up. Thus, even if resection is performed for primary IPNB, additional surgical treatment may be feasible in this setting.

Intraductal papillary neoplasm of bile duct: all rare in one

2020 ◽  
Vol 13 (11) ◽  
pp. e237001
Author(s):  
Aprajita Chaturvedi ◽  
Manjunath Maruti Pol ◽  
Kirti Jangra ◽  
Priyanka Singh
Keyword(s):  
Bile Duct ◽  
Histopathological Examination ◽  
Anatomical Variations ◽  
Small Lesion ◽  
Low Grade ◽  
Pathological Findings ◽  
Intraductal Papillary Neoplasm ◽  
Contrast Enhanced ◽  
Low Grade Dysplasia ◽  
Papillary Neoplasm

A 45-year-old woman was referred from Department of Dermatology to Surgery outpatient department with pruritus since 6 months and an episode of jaundice that lasted for 15 days about 6 months ago. She was referred with a contrast-enhanced MRI finding that showed a small lesion in the lower end of common bile duct. Endoscopy-guided biopsy was performed twice at our hospital, the second revealed low grade dysplasia. Consequently, she underwent pancreaticoduodenectomy. Intraoperatively, there were both vascular and biliary anatomical variations that were missed on preoperative images. On histopathological examination, it turned out to be a mixed variety of intraductal papillary neoplasm of bile duct (IPNB). As all findings were rare in one, hence, we present this case of IPNB that presented to us with variable clinical, radiological, surgical and pathological findings.

scholarly journals Intraductal papillary neoplasm of bile ducts: report of a case and literature review

2019 ◽  
Vol 6 (7) ◽  
pp. 2579
Author(s):  
Nuray Colapkulu ◽  
Gurhan Bas ◽  
Fatih Buyuker ◽  
Damla Beyazadam ◽  
Ibrahim A. Ozemir ◽  
...  
Keyword(s):  
Bile Duct ◽  
Bile Ducts ◽  
Case Reports ◽  
Case Series ◽  
Endoscopic Biopsy ◽  
World Health ◽  
Retrospective Case ◽  
Intraductal Papillary Neoplasm ◽  
Invasive Component ◽  
Papillary Neoplasm

A 67 year old male with right upper quadrant abdominal pain diagnosed with intraductal papillary neoplasm of bile ducts (IPNB) by endoscopic biopsy. The patient was treated surgically and disease free on first year follow-up. Intraductal papillary neoplasm of bile duct (IPNB) is a rare entity with malignant counterparts and recently classified by The World Health Organization. The aim of this study is to present a case of IPNB and review the literature. Pubmed/MEDLINE was searched and articles were extracted. Twenty four case reports and 17 retrospective case series were evaluated. From 41 studies, 824 cases were included. There was slight male predominancy among patients and almost all cases were from eastern countries. Even though the etiology remains unclear, hepatolithiasis was the most common potential etiological association. Most cases were treated with surgical intervention. More than half of the 577 resected specimens had invasive component. Incidence rate of histopathological subtypes were as fallowed: Intestinal (35%), pancreaticobiliary (32%), gastric (19%) and oncocytic (12%). Intraductal papillary neoplasm of bile duct has an increased malignancy rates at postoperative pathological diagnosis, consequently early surgical management is important.

scholarly journals A case of hepatic intraductal papillary neoplasm of the bile duct

2021 ◽  
Author(s):  
Eisuke Mukaida ◽  
Akio Tamura ◽  
Kunihiro Yoshioka ◽  
Masao Nishiya ◽  
Tamotsu Sugai
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bile Duct ◽  
Invasive Carcinoma ◽  
Pathological Findings ◽  
Resonance Imaging ◽  
Intraductal Papillary Neoplasm ◽  
History Of ◽  
Right Lobe ◽  
The Right ◽  
Papillary Neoplasm

In this report, we present a 57-year-old female with a history of mild alcoholic liver disease during a medical check-up. Abdominal computed tomography and magnetic resonance imaging showed a multicystic mass with a solid enhancing mural nodule in the right lobe of the liver. Subsequently, laparoscopic right liver lobectomy was performed and pathological findings revealed intraductal papillary neoplasm of the bile duct (IPNB) with an associated invasive carcinoma. IPNB is a relatively rare disease that should be considered in the differential diagnosis of hepatic cystic tumours. Our case report highlights the importance of capturing image findings of the IPNB as this disease has a high potential for malignancy.

scholarly journals Branch-type intraductal papillary neoplasm of the bile duct treated with laparoscopic anatomical resection: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Rumi Matono ◽  
Mizuki Ninomiya ◽  
Kazutoyo Morita ◽  
Takahiro Tomino ◽  
Yumi Oshiro ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Anatomical Resection ◽  
Intraductal Papillary Neoplasm ◽  
Papillary Neoplasm ◽  
Branch Type

scholarly journals A Resected Case of Mucinous Adenocarcinoma of the Duodenum, Mimicking Intraductal Papillary Neoplasm of the Bile Duct

2015 ◽  
Vol 100 (11-12) ◽  
pp. 1443-1448
Author(s):  
Norio Kubo ◽  
Hideki Suzuki ◽  
Norihiro Ishii ◽  
Mariko Tsukagoshi ◽  
Akira Watanabe ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Transverse Colon ◽  
Extrahepatic Bile Duct ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Mucinous Carcinoma ◽  
Villous Tumor ◽  
Intraductal Papillary Neoplasm ◽  
The Common ◽  
Papillary Neoplasm

Duodenum mucinous carcinoma is very rare, and the prognosis of the patient is very bad, especially when the tumor is invasive to other organs. In this case, duodenum carcinoma was invasive to common bile duct and transverse colon. Mucinous fluid, which was secreted from a duodenum tumor, was found in the dilatated bile duct. The intraductal papillary neoplasm of the bile duct was considered a differential diagnosis. We performed aggressive resection and had a good prognosis. A 74-year-old woman received a diagnosis of cholangitis and was treated with antibiotic drugs. Endoscopic retrograde cholangiopancreatography revealed a defect in the lower common bile duct with the mucoid fluid. We suspected intraductal papillary neoplasm of the bile duct, but no malignant cells were detected. One year later, gastrointestinal fiberscopy revealed a villous tumor in the postbulbar portion of the duodenum; adenocarcinoma was detected in biopsy specimens. Computed tomography revealed dilatation of the duodenum with an enhanced tumor, and dilatation of both the common and intrahepatic bile ducts. Magnetic resonance cholangiopancreatography revealed that the duodenum was connected with the common bile duct and ascending colon. We resected the segmental duodenum, extrahepatic bile duct, left lobe of liver, a partial of the transverse colon, and associated lymph nodes. Although the advanced duodenal carcinoma had poor prognosis, the patient was alive, without recurrence, 5 years after the operation.

scholarly journals A case of branch duct type intraductal papillary neoplasm of the bile duct treated by open surgery after 11 years of follow-up

2013 ◽  
Vol 1 (6) ◽  
pp. 965-969 ◽  
Author(s):  
MITSURU FUJITA ◽  
NORITAKA WAKUI ◽  
YOSHIYA YAMAUCHI ◽  
YUKI TAKEDA ◽  
TAKEMASA SATO ◽  
...  
Keyword(s):  
Bile Duct ◽  
Open Surgery ◽  
Branch Duct ◽  
Intraductal Papillary Neoplasm ◽  
Branch Duct Type ◽  
Papillary Neoplasm
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