Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation

The unique hydrophobic 3-D topology of the neopentylene ring fusion is explored in the context of an analogue of the non-steroidal anti-inflammatory drug, ibuprofen.

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POTENTIAL TREATMENT OPTION FOR COVID 19 RELATED ANOSMIA - CHAMOMILE (MATRRICARIA CHAMOMILLA) EXTRACT NASAL IRRIGATION - A LITERATURE REVIEW.

International Journal of Medical Science and Diagnosis Research ◽

10.32553/ijmsdr.v5i1.738 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Haider, Romella

Keyword(s):

Literature Review ◽

Meta Analysis ◽

Cochrane Library ◽

Nasal Irrigation ◽

Presenting Symptoms ◽

Global Pandemic ◽

Literature Searches ◽

Traditional Persian Medicine ◽

Promising Treatment ◽

Anti Inflammatory

Corona virus or Covid-19 infection that has rapidly evolved into a global pandemic shortly after its emergence in China in December 2019, demands smart, preventive and treatment recommendations especially related to its early onset symptoms. Anosmia, has now been identified among one of the earliest presenting symptoms in Covid-19 patients. Reports of anosmia in otherwise asymptomatic persons have led to interest in this sign as a potential early indicator of this disease Medical publications about anosmia with COVID-19 are still uncertain of its causative mechanism. The aim of this review is to provide literature review, as well as evidence-based recommendations for the management of patients with COVID-19 related anosmia, using Chamomile (Matrricaria chamomilla) extract nasal irrigation. Extensive database search from PubMed, Cochrane library, and Web of science, gray literature searches from Google Scholar, WHO and Traditional Persian Medicine textbook search such as Makhzan al Adwiyehe was performed. To support the literature, 8 most recent articles published in current year including systematic reviews and meta-analysis as well as clinical trial studies were finally selected to see the effectiveness of Chamomile in treatment of various symptoms of Covid-19. Chamomile (Matrricaria chamomilla) extract based on its pigenin and Luteolin (causing reduction of leukocyte infiltration), a-Bisabolol (which has anti-inflammatory role), Chamazulene (that provides anti-inflammatory and antipyretic role), Guaiazulene (antipyretic), Matricin (Anti-inflammatory role) and other appreciated roles mentioned in this study may serve as a promising treatment for Covid-19 induced anosmia, especially when used as nasal irrigation. Keywords: Chamomile, Covid-19 related Anosmia, Babouneh, loss of smell.

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Naringenin, a flavanone with antiviral and anti‐inflammatory effects: A promising treatment strategy against COVID ‐19

Phytotherapy Research ◽

10.1002/ptr.6781 ◽

2020 ◽

Vol 34 (12) ◽

pp. 3137-3147 ◽

Cited By ~ 2

Author(s):

Helda Tutunchi ◽

Fatemeh Naeini ◽

Alireza Ostadrahimi ◽

Mohammad Javad Hosseinzadeh‐Attar

Keyword(s):

Treatment Strategy ◽

Promising Treatment ◽

Anti Inflammatory

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Differential chemoreactome analysis of synergistic combinations of tolperisone and nonsteroidal anti-inflammatory drugs

Neurology neuropsychiatry Psychosomatics ◽

10.14412/2074-2711-2019-2-78-85 ◽

2019 ◽

Vol 11 (2) ◽

pp. 78-85 ◽

Cited By ~ 5

Author(s):

I. Yu. Torshin ◽

O. A. Gromova ◽

L. V. Stakhovskaya ◽

V. A. Semenov ◽

A. N. Gromov

Keyword(s):

Biological Activities ◽

Muscle Relaxants ◽

Antitumor Effects ◽

Concurrent Use ◽

Promising Treatment ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Muscle Hypertonia ◽

Synergistic Combinations ◽

Necrosis Factor

The concurrent use of muscle relaxants and nonsteroidal anti-inflammatory drugs (NSAIDs) is a promising treatment for painful muscle hypertonia and convulsive states.Objective: to identify the most effective and safe synergist combinations of tolperisone and NSAIDs.Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of the muscle relaxant tolperisone and five NSAIDs (dexketoprofen, etoricoxib, meloxicam, naproxen, and diclofenac). The biological activities of the molecules under study were assessed in five sections: 1) inhibition of the proteins of prostaglandin and leukotriene metabolism; 2) inhibition of the effects of the transcription factor nuclear factor kappa, tumor necrosis factor-, and other anti-inflammatory mechanisms; 3) inhibition of excessive blood coagulation and platelet aggregation; 4) vasodynamic effects; 5) antitumor properties on cell lines in culture.Results and discussion. Based on the differences in the pharmacological activity profiles of tolperisone and NSAIDs under study, the investigators identified the most promising synergistic combinations, in which both active ingredients complemented each other as effectively and safely as possible. The obtained estimates of the degree of synergism of various combinations of tolperisone and NSAIDs hold that the most promising antithrombotic, and antitumor effects.Conclusion. The results of this study will help adequately choose combinations of muscle relaxants and NSAIDs in patients with muscle hypertonia, which will be able to improve the efficiency and safety of treatment.

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Pramoxine containing topical formulation of eberconazole in the management of dermatophytosis in India: a consensus statement

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20214929 ◽

2021 ◽

Vol 8 (1) ◽

pp. 175

Author(s):

Uday Khopkar ◽

Shyamanta Barua ◽

Sanjay Kumar Rathi ◽

A. N. Tiwari ◽

Balakrishna Nikam ◽

...

Keyword(s):

Panel Discussion ◽

Age Groups ◽

Current Treatment ◽

Public Health Issue ◽

Topical Formulation ◽

Over The Counter ◽

Modified Delphi ◽

Consensus Document ◽

Promising Treatment ◽

Anti Inflammatory

Dermatophytosis, a superficial fungal infection has attained significant extents among Indian population. Its clinical presentation is diverse, often in terms of morphology, severity type and involvement of all age groups. Management of dermatophytosis has become an important public health issue in India. Cases of steroid modified dermatophytosis are being encountered frequently, mostly caused due to the inadvertent use of steroid in combination with topical antifungal agents. This combination is available over the counter and is often used for the management of inflammation and pruritis associated with the disease. Current treatment recommendations must be reviewed as per the current clinical scenario of the disease. Thus, a topical formulation of an anti-itch agent like pramoxine and antifungal agent with an anti-inflammatory property like eberconazole holds a promising treatment approach for dermatophytosis. This article focuses on the challenges encountered in the management of dermatophytosis and strategies for optimizing treatment for better patient outcomes. An expert’s panel discussion was conducted involving fifteen dermatologists all over India, during which modified Delphi method was executed for a set of nine statements. Agreement of more than 75% was set to reach the consensus. This consensus document was developed to review the available evidence and make recommendation based on the expert group’s opinion for the use of pramoxine containing topical formulation of eberconazole, as it provides the benefit of having an anti-inflammatory and anti-pruritic activity in a single formulation, where pramoxine can be utilised as an excipient to combat pruritis associated with dermatophytosis.

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