scholarly journals Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Philip J. Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Perceived Exertion ◽  
Ketone Bodies ◽  
Rating Of Perceived Exertion ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods Thirteen recreational male distance runners (24.8 ± 9.6 years, 72.5 ± 8.3 kg, VO2max 60.1 ± 5.4 ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1: 22.1 g) or two (KS2: 44.2 g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 and 60 min), post-exercise (+ 0 min, + 15 min). Time, heart rate (HR), rating of perceived exertion (RPE), affect, respiratory exchange ratio, oxygen consumption (VO2), carbon dioxide production, and ventilation were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, HR, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion Novel βHB + MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, HR, affect, RPE, and exercise performance.

scholarly journals Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual and Performance Parameters

2020 ◽  
Author(s):  
Philip J. Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Perceived Exertion ◽  
Ketone Bodies ◽  
Rating Of Perceived Exertion ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, heart rate (HR), rating of perceived exertion (RPE), affect, respiratory exchange ratio (RER), oxygen consumption (VO2), carbon dioxide production (VCO2), and ventilation (VE) were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, HR , affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, HR, affect, RPE, and exercise performance.

scholarly journals Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual, and Performance Parameters

2020 ◽  
Author(s):  
Philip Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Ketone Bodies ◽  
Time Trial ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, HR, RPE, affect, RER, VO2, VCO2, and VE were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance.

scholarly journals Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual, and Performance Parameters

2020 ◽  
Author(s):  
Philip Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Ketone Bodies ◽  
Time Trial ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, HR, RPE, affect, RER, VO2, VCO2, and VE were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance.

scholarly journals Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual, and Performance Parameters

2020 ◽  
Author(s):  
Philip Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Ketone Bodies ◽  
Time Trial ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols.Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, HR, RPE, affect, RER, VO2, VCO2, and VE were measured during exercise. Cognitive performance was evaluated prior to and post-exercise.Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance.

Carbohydrate mouth rinsing improves resistance training session performance

2018 ◽  
Vol 13 (5) ◽  
pp. 804-809 ◽  
Author(s):  
Luciana S Decimoni ◽  
Victor M Curty ◽  
Livia Almeida ◽  
Alexander J Koch ◽  
Jeffrey M Willardson ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Exercise Performance ◽  
Repeated Measures ◽  
Perceived Exertion ◽  
Bench Press ◽  
Statistical Significance ◽  
Training Session ◽  
Rating Of Perceived Exertion ◽  
Double Blind ◽  
Mouth Rinsing

We investigated the effect of carbohydrate mouth rinsing on resistance exercise performance. Fifteen recreationally trained women (age 26 ± 4 y; height 1.61.9 ± 5.1 m; weight 59.5 ± 8.2 kg) completed two resistance exercise bouts consisting of three sets of five exercises (half-squat, leg press, bench press, military press, and seated row) to volitional fatigue with a 10 repetition-maximum load. Immediately prior to and during the middle of each exercise bout, subjects mouth rinsed for 10 s with 100 mL of either a 6% maltodextrin solution (CHO) or an artificially flavored solution (PLA) in a randomized, double-blind, counterbalanced fashion. Heart rate and perceived exertion were compared between conditions using a 2 (conditions) × 15 (time points) repeated measures ANOVA. Significant main effects were further analyzed using pairwise comparisons with Bonferroni post hoc tests. Total volume (exercises * sets * repetitions * load) between sessions was compared with a Student’s t-test. Statistical significance was set at p ≤ 0.05 level of confidence. The CHO resulted in more repetitions performed during half-squat, bench press, military press, and seated row, for a significantly greater (∼12%) total volume load lifted versus PLA ( p = 0.039, ES: 0.49). Rating of perceived exertion was also significantly lower in the CHO versus PLA ( p = 0.020, ES: 0.28). These data indicate that CHO mouth rinsing can enhance high-volume resistance exercise performance and lower ratings of perceived exertion.

Increased Cardiorespiratory Stress During Submaximal Cycling After Ketone Monoester Ingestion in Endurance-Trained Adults

2021 ◽  
Author(s):  
Devin Goddard McCarthy ◽  
William Bostad ◽  
Fiona Jane Powley ◽  
Jonathan P. Little ◽  
Douglas Richards ◽  
...  
Keyword(s):  
Body Mass ◽  
Ketone Body ◽  
Perceived Exertion ◽  
Bolus Dose ◽  
Ventilatory Threshold ◽  
Time Trial ◽  
Rating Of Perceived Exertion ◽  
Threshold Intensity ◽  
Double Blind ◽  
And Performance

There is growing interest in the effect of exogenous ketone body supplementation on exercise responses and performance. The limited studies to date have yielded equivocal data, likely due in part to differences in dosing strategy, increase in blood ketones, and participant training status. Using a randomized, double-blind, counterbalanced design, we examined the effect of ingesting a ketone monoester (KE) supplement (600 mg/kg body mass) or flavour-matched placebo in endurance-trained adults (n=10 males, n=9 females; VO2peak=57±8 ml/kg/min). Participants performed a 30-min cycling bout at ventilatory threshold intensity (71±3% VO2peak), followed 15 min later by a 3 kJ/kg body mass time-trial. KE versus placebo ingestion increased plasma [β-hydroxybutyrate] before exercise (3.9±1.0 vs 0.2±0.3 mM, p<0.0001, dz=3.4), ventilation (77±17 vs 71±15 L/min, p<0.0001, dz=1.3) and heart rate (155±11 vs 150±11 beats/min, p<0.001, dz=1.2) during exercise, and rating of perceived exertion at the end of exercise (15.4±1.6 vs 14.5±1.2, p<0.01, dz=0.85). Plasma [β-hydroxybutyrate] remained higher after KE vs placebo ingestion before the time-trial (3.5±1.0 vs 0.3±0.2 mM, p<0.0001, dz=3.1), but performance was not different (KE: 16:25±2:50 vs placebo: 16:06±2:40 min:s, p=0.20; dz=0.31). We conclude that acute ingestion of a relatively large KE bolus dose increased markers of cardiorespiratory stress during submaximal exercise in endurance-trained participants. Novelty bullets: •Limited studies have yielded equivocal data regarding exercise responses after acute ketone body supplementation. •Using a randomized, double-blind, placebo-controlled, counterbalanced design, we found that ingestion of a large bolus dose of a commercial ketone monoester supplement increased markers of cardiorespiratory stress during cycling at ventilatory threshold intensity in endurance-trained adults.

scholarly journals Complex Interplay Between Determinants of Pacing and Performance During 20-km Cycle Time Trials

2012 ◽  
Vol 7 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Andrew Renfree ◽  
Julia West ◽  
Mark Corbett ◽  
Clare Rhoden ◽  
Alan St Clair Gibson
Keyword(s):  
Negative Affect ◽  
Blood Lactate ◽  
Power Output ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Rating Of Perceived Exertion ◽  
Physiological Status ◽  
Pacing Strategy ◽  
And Performance

Purpose:This study examined the determinants of pacing strategy and performance during self-paced maximal exercise.Methods:Eight well-trained cyclists completed two 20-km time trials. Power output, rating of perceived exertion (RPE), positive and negative affect, and iEMG activity of the active musculature were recorded every 0.5 km, confidence in achieving preexercise goals was assessed every 5 km, and blood lactate and pH were measured postexercise. Differences in all parameters were assessed between fastest (FAST) and slowest (SLOW) trials performed.Results:Mean power output was significantly higher during the initial 90% of FAST, but not the final 10%, and blood lactate concentration was significantly higher and pH significantly lower following FAST. Mean iEMG activity was significantly higher throughout SLOW. Rating of perceived exertion was similar throughout both trials, but participants had significantly more positive affect and less negative affect throughout FAST. Participants grew less confident in their ability to achieve their goals throughout SLOW.Conclusions:The results suggest that affect may be the primary psychological regulator of pacing strategy and that higher levels of positivity and lower levels of negativity may have been associated with a more aggressive strategy during FAST. Although the exact mechanisms through which affect acts to influence performance are unclear, it may determine the degree of physiological disruption that can be tolerated, or be reflective of peripheral physiological status in relation to the still to be completed exercise task.

scholarly journals Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes: A Pilot Study

2019 ◽  
Vol 69 (1) ◽  
pp. 169-178 ◽  
Author(s):  
Hanen Hafedh ◽  
Maamer Slimani ◽  
Bianca Miarka ◽  
Ramzi Bettayeb ◽  
Nicola Luigi Bragazzi
Keyword(s):  
Heart Rate ◽  
Aerobic Exercise ◽  
Exercise Performance ◽  
Perceived Exertion ◽  
Female Athletes ◽  
Blood Glucose Concentration ◽  
Rating Of Perceived Exertion ◽  
Double Blind ◽  
Terbutaline Sulfate ◽  
Cardiovascular Variables

Abstract This study aimed to investigate the effects of beta2‐agonist terbutaline sulfate (TER) at a supra‐therapeutic dose (8 mg) on aerobic exercise performance. Twelve (6 females and 6 males) amateur athletes familiarized with all experimental procedures had their anthropometric data obtained on day 1. On days 2 and 3 either 8 mg of TER or a placebo (PLA) was administered orally (double‐blind manner) to participants who had rested for 3 h prior to aerobic exercise performance 20 m multistage fitness test (MSFT)]. This test was used to predict maximal oxygen uptake (VO2max) and velocity at which VO2max occurs (vVO2max). The Borg rating of perceived exertion (RPE), cardiovascular variables [heart rate (HR) and blood pressure (BP)] and blood glucose concentration [BGC] were obtained 15 min pre‐ and immediately post‐MSFT. Significant mean group differences were reported between PLA and TER groups (p < 0.05), respectively, in the RPE (15.6 ± 1.2 vs. 17.3 ± 1.5 a.u.), maximum heart rate (HRmax: 191.2 ± 7.1 vs. 197.2 ± 8.6 bpm) and BGC (118.4 ± 18.3 vs. 141.2 ± 15.8 mg/dL) post‐MSFT. The main effect of gender (male vs. female) in TER and PLA groups (p< 0.05) was observed, with higher estimated VO2max, vVO2max, HRmax and a lower mean HR pre‐test in male than female athletes. For these reasons, the inclusion of TER in the Prohibited List should be re‐discussed because of the lack of ergogenic effects.

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