Lymph node metastatic patterns and its clinical significance for thoracic superficial esophageal squamous cell carcinoma

Abstract Background and objectives The optimal therapeutic method for patients with superficial esophageal squamous cell carcinoma (sESCC) remains to be established. Methods Clinical data of all the patients from 2002 to 2014 who underwent curative esophagectomy and three-field lymphadenectomy for thoracic sESCC were collected based on a prospectively-maintained database. The pattern of lymph node metastasis was analyzed based on the depth of tumor invasion, tumor location and surgical fields. Results The involved lymph node region was associated to the tumor location, however, upper mediastinal and perigastric region was the most vulnerable region. The incidence of lymph node metastasis increased with the depth of tumor invasion. No lymph node involvement was found in tumors invading proper mucosa (M2), while the pattern of positive lymph nodes in tumors invading the deepest 1/3 submucosa was similar to that in advanced ESCC. Lymphatic invasion, tumor location and upper mediastinal lymph node involvement were independent predictors for cervical lymph node metastasis. For patients without lymphatic invasion, the positive predictive value of upper mediastinal lymph node metastasis for positive cervical lymph node was low (0 ~ 25%), while the negative predictive value was extremely high, wherever the tumor located (93.8 ~ 100%). Conclusions Tumors invading till proper mucosa was the best indication for endoscopic mucosa resection. Mediastinal-abdominal lymphadenectomy was essential for sESCC invading beyond proper mucosa. For those without lymphatic invasion, cervical lymphadenectomy might be avoided in case of negative upper mediastinal lymph node.

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PS01.156: THE PATTERN OF LYMPH NODE METASTATIC AND ITS CLINICAL SIGNIFICANCE FOR THORACIC SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMATHE PATTERN OF LYMPH NODE METASTATIC AND ITS CLINICAL SIGNIFICANCE FOR THORACIC SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps01.156 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 93-94

Author(s):

Shaohua Wang ◽

Xiaofeng Chen ◽

An Wang

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Squamous Cell ◽

Tumor Invasion ◽

Mediastinal Lymph Node ◽

Tumor Location ◽

Lymph Node Involvement ◽

Lymphatic Invasion ◽

Node Metastasis ◽

Node Involvement

Abstract Background The pattern of lymph node metastasis and surgical method in superficial esophageal squamous cell carcinoma (sESCC) remains to be established. Methods Clinical data of all patients from 2003 to 2015 who underwent curative esophagectomy for thoracic sESCC were collected based on a prospectively-maintained database. The pattern of lymph node metastasis was analyzed based on depth of tumor invasion and tumor location. Results The involved lymph node region was associated to the tumor location, however, upper mediastinal and perigastric region was the most vulnerable region. As for the depth of tumor invasion, the incidence of lymph node metastasis increased with the depth of tumor invasion going deeper. No lymph node involvement was found in tumors invading proper mucosa (M2), while the distribution of positive lymph nodes in tumors invading the deepest 1/3 submucosa was similar to that in advanced ESCC. Lymphatic invasion, tumor location and upper mediastinal lymph node involvement were independent predictors for cervical lymph node metastasis. For patients without lymphatic invasion, the positive predictive value of upper mediastinal lymph node metastasis for positive cervical lymph node was low (0∼25%), while the negative predictive value was very high, wherever the tumor located (93.8∼100%). Conclusion Tumors invading till proper mucosa was the best indication for endoscopic mucosa resection; Tumors invading the deepest 1/3 submucosa might benefit from neoadjuvant therapy; Mediastinal-abdominal lymphadenectomy was essential for sESCC. For those without lymphatic invasion, cervical lymphadenectomy might be avoided in case of negative upper mediastinal lymph node. Disclosure All authors have declared no conflicts of interest.

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Colorectal Cancer Presenting as Single Pulmonary Hilar Lymph Node Metastasis

Case Reports in Surgery ◽

10.1155/2018/5474919 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3

Author(s):

Ahmed M. Habib ◽

Xenophon Kassianides ◽

Samuel Chan ◽

Mahmoud Loubani ◽

Syed Qadri

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Mediastinal Lymph Node ◽

Lymph Node Involvement ◽

Pulmonary Metastasectomy ◽

Hilar Lymph Node ◽

Node Metastasis ◽

Mediastinal Metastasis ◽

Node Involvement ◽

Hilar Lymph Node Metastasis

Colorectal carcinoma is the second biggest cancer responsible for mortality. Lung metastasis is the commonest, following the liver. It is not uncommon to perform pulmonary metastasectomy and identify mediastinal metastasis. Previous studies have identified incidental lymph node involvement following routine mediastinal lymph node clearance in 20–50% of cases. However, solitary intrathoracic lymph node metastasis is exceedingly rare. Even when present, it is usually metachronous. In our case, we present an exceedingly rare case whereby the intrathoracic lymph node metastasis is solitary, not accompanying pulmonary disease and with no liver metastasis. We also review the evidence for mediastinal lymphadenectomy in the literature.

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Isolated submandibular lymph node metastasis in pancreatic adenocarcinoma

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2019.0006 ◽

2019 ◽

Vol 101 (3) ◽

pp. e94-e95

Author(s):

Taiwo Oyebola ◽

Akash Mavilakandy ◽

Peter Conboy ◽

Neil Bhardwaj

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Pancreatic Adenocarcinoma ◽

Late Stage ◽

Cervical Lymph Node ◽

Lymph Node Involvement ◽

Node Metastasis ◽

Submandibular Lymph Node ◽

Node Involvement

Pancreatic adenocarcinoma is a highly aggressive malignancy that usually presents at a late stage. Common sites of metastasis include the liver, lung and adjacent lymph nodes. Cervical lymph node involvement has been reported previously but there are no documented cases of submandibular lymph node metastasis in the available literature. We describe a case of pancreatic adenocarcinoma metastasis to the left submandibular lymph node with no confirmed concurrent sites of metastasis.

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228 Predictive factors of lymph node involvement and topography of lymph node metastasis in patients with epithelial ovarian cancer

10.1136/ijgc-2020-igcs.195 ◽

2020 ◽

Author(s):

D Atallah ◽

M Moubarak ◽

B Dagher ◽

N Khalil ◽

N El Kassis ◽

...

Keyword(s):

Ovarian Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Epithelial Ovarian Cancer ◽

Predictive Factors ◽

Lymph Node Involvement ◽

Node Metastasis ◽

Node Involvement

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A prospective study to evaluate the impact and independency of depth of invasion in comparison with other clinicopathologic prognostic variables in oral cavity malignancy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20200149 ◽

2020 ◽

Vol 6 (2) ◽

pp. 347

Author(s):

Subbiah Shanmugam ◽

Gopu Govindasamy ◽

X. Gerald Anand Raja

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Cavity ◽

Staging System ◽

Lymph Node Involvement ◽

Stage Migration ◽

Depth Of Invasion ◽

Node Metastasis ◽

Node Involvement ◽

The Impact

Background: Depth of invasion is included in the staging of oral cavity malignancies in the recent 8th edition of American Joint Committee on Cancer or tumour, node and metastasis staging system. This study analyses the impact of diffuse optical imaging (DOI) on incidence of lymph node involvement, stage migration, postoperative margin and independency.Methods: Postoperative HPE of fifty patients with oral cavity malignancy operated in our institute from January 2018 were collected. Depth of invasion and other pathological parameters were documented. DOI divided into three groups and statistical analysis done. Results: No lymph node metastasis is found in superficial tumours, 43% of intermediate thickness and 76% of deep tumours had lymph node involvement. Positive margin is seen only in patients with tumour DOI more than 0.5 cm, more than 50% of deep tumours had close margins while 75% of superficial tumours had adequate margin. Out of the 24 T3 tumours in this study 13 were upstaged due to inclusion of DOI, which would have been T2 according to the previous staging system. There is 54.1% (13 out of 24) upstaging in T3 tumours (T2 to T3), 23% (3 out of 13) in T2 (T1 to T2). There is no significant correlation between DOI and anatomical site, tumour size, tumour thickness, lymphovascular invasion and grade.Conclusions: Depth of invasion in oral cavity malignancies impacts adversely lymph node metastasis and margin status. It is an independent prognostic factor in oral cavity malignancy.

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P3-07-27: ROCK II Expression Can Be a Potential Marker of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Sentinel Lymph Node Involvement.

10.1158/0008-5472.sabcs11-p3-07-27 ◽

2011 ◽

Author(s):

H Shigematsu ◽

K Taguchi ◽

S Shiotani ◽

H Kawaguchi ◽

K Nishiyama ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Node Metastasis ◽

Cancer Patients ◽

Lymph Node Involvement ◽

Breast Cancer Patients ◽

Node Metastasis ◽

Potential Marker ◽

Node Involvement

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558 Validation of Three Different Nomograms to Predict the Risk of Non-Sentinel Lymph Node Involvement in Turkish Breast Cancer Patients with Sentinel Lymph Node Metastasis

European Journal of Cancer ◽

10.1016/s0959-8049(12)70623-8 ◽

2012 ◽

Vol 48 ◽

pp. S208

Author(s):

L. Yeniay ◽

A.C. Karaca ◽

E. Carti ◽

N. Ozdemir ◽

U. Yararbas ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Node Metastasis ◽

Cancer Patients ◽

Lymph Node Involvement ◽

Sentinel Lymph Node Metastasis ◽

Breast Cancer Patients ◽

Node Metastasis ◽

Node Involvement

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Detection of Lymphovascular Invasion by D2-40 (Podoplanin) Immunoexpression in Endometrial Cancer

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e318269139b ◽

2012 ◽

Vol 22 (8) ◽

pp. 1442-1448 ◽

Cited By ~ 25

Author(s):

Sarah K. Weber ◽

Axel Sauerwald ◽

Martin Pölcher ◽

Michael Braun ◽

Manuel Debald ◽

...

Keyword(s):

Overall Survival ◽

Endometrial Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymphovascular Invasion ◽

Lymph Node Involvement ◽

Lymph Vessel ◽

Node Metastasis ◽

Lymph Vessel Invasion ◽

Node Involvement

BackgroundLymph node involvement is a major feature in tumor spread of endometrial cancer and predicts prognosis. Therefore, evaluation of lymph vessel invasion (LVI) in tumor tissue as a predictor for lymph node metastasis is of great importance. Immunostaining of D2-40 (podoplanin), a specific marker for lymphatic endothelial cells, might be able to increase the detection rate of LVI compared with conventional hematoxylin-eosin (H-E) staining. The aim of this retrospective study was to analyze the eligibility of D2-40–based LVI evaluation for the prediction of lymph node metastases and patients’ outcome.Patients and MethodsImmunohistochemical staining with D2-40 monoclonal antibodies was performed on paraffin-embedded tissue sections of 182 patients with primary endometrioid adenocarcinoma treated in 1 gynecologic cancer center. Tumors were screened for the presence of LVI. Correlations with clinicopathological features and clinical outcome were assessed.ResultsImmunostaining of D2-40 significantly increased the frequency LVI detection compared with conventional H-E staining. Lymph vessel invasion was identified by D2-40 in 53 (29.1%) of 182 tumors compared with 34 (18.3%) of 182 carcinomas by routine H-E staining (P = 0.001). D2-40 LVI was detectable in 81.0% (17/21) of nodal-positive tumors and significantly predicted lymph node metastasis (P = 0.001). Furthermore, D2-40 LVI was an independent prognostic factor for patients overall survival considering tumor stage, lymph node involvement, and tumor differentiation (P < 0.01). D2-40–negative tumors confined to the inner half of the myometrium showed an excellent outcome (5-year overall survival, 97.8%).ConclusionsD2-40–based LVI assessment improves the histopathological detection of lymphovascular invasion in endometrial cancer. Furthermore, LVI is of prognostic value and predicts lymph node metastasis. D2-40 LVI detection might help to select endometrial cancer patients who will benefit from a lymphadenectomy.

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