Analysis on factors behind sentinel lymph node metastasis in breast cancer by color ultrasonography, molybdenum target and pathological detection

Background This study aimed to collect the factors underlying the metastasis of breast cancer and sentinel lymph node, and to screen and analyze the risk factors of sentinel lymph node metastasis, so as to provide reference and basis for clinical work. Methods A total of 100 patients with breast cancer were enrolled in the study. These patients received treatment in our hospital from May 2017 to May 2020. The general information, the characteristics of the color Doppler echocardiography, molybdenum, conventional pathology and molecular pathology of the patients were collected. The influencing factors of sentinel lymph node metastasis in breast cancer patients were retrospectively analyzed. Results In this study, age, tumor diameter and BI-RADS category, pathology type, expression profiles of CK5/6, EGFR, and CK19, and TP53 and BRAC1/2 mutations were independent risk factors for sentinel lymph node metastasis in breast cancer (P<0.05). The number and locations of tumors, the quadrant of tumors, the regularity of tumor margins, the presence of blood flow signals, the presence of posterior echo attenuation, the presence of calcification, histological grade, molecular typing, and mutations of BRAF, ATM and PALB2 were irrelevant factors (P>0.05). Conclusions In conclusion, age, tumor diameter, Bi-rads category, invasive type, expression of CK5/6, EGFR and CK19, and mutations of TP53 and BRAC1/2 were positively correlated with sentinel lymph node metastasis. They are independent risk factors that should be paid more attention in clinical studies, to strengthen the management and control of sentinel lymph node metastasis of high-risk breast cancer, and support early chemotherapy or targeted therapy.

Correlation between Grading Histopathology and Sentinel Lymph Node Metastasis in Early Breast Cancer in University of Sumatera Utara Hospital

BACKGROUND: Breast cancer is a malignancy in breast tissue from the duct or lobar epithelium. American Joint Committee on Cancer has specified important prognostic factors such as primary tumor size, regional lymph node status, and distant metastasis. Axillary lymph node status has been one of the most reliable prognostic factors in early breast cancer in women. Axillary lymph node dissection is an old method to identify metastasis in axillary lymph nodes and started being replaced by sentinel lymph node biopsy (SLNB). SLNB has been introduced as a minimal invasive procedure, but in Indonesia, this procedure cannot be done due to technology limitation. Grading tumor is one of the predictor factors that can predict lymph node metastasis. This predictor factor has been associated with sentinel lymph node metastasis significantly. AIM: According to this, we conduct this study to analyze the correlation between grading histopathology in breast cancer with sentinel lymph node metastasis to lower false-negative rate in SLNB using methylene blue dye. MATERIALS AND METHODS: In this study, we included 51 patients that qualified using inclusion and exclusion criteria. Then, sentinel lymph node metastasis and grading histopathology data were retrieved from the patient’s medical record. This data are analyzed using SPSS with Chi-square test. RESULTS: The most type of breast cancer in this study is invasive ductal carcinoma was found in 40 patients (78.4%). There are 22 of 51 patients (51.6%) with metastasis to sentinel lymph node, have Grade 3 in histopathologic findings. CONCLUSIONS: The statistical evaluation showed that there is significant correlation between grading histopathology and SLNB with p = 0.001.