scholarly journals Efficacy and potential mechanisms of Chinese herbal compounds in coronavirus disease 2019: advances of laboratory and clinical studies

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mu-Feng Xiang ◽  
Cheng-Tao Jin ◽  
Li-Hua Sun ◽  
Zhi-Hui Zhang ◽  
Jing-Jing Yao ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Clinical Symptoms ◽  
Relevant Literature ◽  
Efficacy And Safety ◽  
Organ Function ◽  
Pharmacological Activities ◽  
Routine Treatment ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
The World

AbstractThe Coronavirus disease 2019 (COVID-19) pandemic is still spread and has made a severe public health threat around the world. To improve disease progression, emerging Chinese herbal compounds were used in clinical practice and some agents have proven beneficial in treating COVID-19. Here, the relevant literature from basic researches to clinical application were identified and comprehensively assessed. A variety of Chinese herbal compounds have been reported to be effective in improving symptoms and outcomes in patients with COVID-19, particularly together with routine treatment strategy. The pharmacological activities were mainly attributed to the relief of clinical symptoms, inhibition of cytokine storm, and improvement of organ function. Besides, the development of novel antiviral drugs from medicinal herbs were further discussed. The updated laboratory and clinical studies provided the evidence of Chinese herbal compounds such as Lianhua Qingwen prescription, Shufeng Jiedu prescription, and Qingfei Paidu Tang for the relief of COVID-19. However, both of the randomized controlled trials and real world researches need to be done for supporting the evidence including the efficacy and safety in fighting COVID-19.

scholarly journals Should we really STOP treating patients with IgA nephropathy with steroids?

2018 ◽  
Vol 105 (2) ◽  
pp. 101-109 ◽  
Author(s):  
F Locatelli ◽  
L Del Vecchio ◽  
C Ponticelli
Keyword(s):  
Iga Nephropathy ◽  
Low Dose ◽  
Benign Disease ◽  
Efficacy And Safety ◽  
End Stage Kidney Disease ◽  
Primary Glomerulonephritis ◽  
Randomized Controlled ◽  
The World ◽  
Rate Of Progression ◽  
End Stage

IgA nephropathy (IgAN) is the most common primary glomerulonephritis all over the world. Once considered as a benign disease, today the scientific community is aware that a significant percentage of patients eventually progress to end-stage kidney disease (ESKD). The rate of progression is often very slow. Since 1980s, several therapeutic attempts have been made with steroids. Despite different molecules, doses, and lengths of treatment, the majority of uncontrolled and controlled studies found benefits in terms of proteinuria reduction and reduction of the risk of ESKD. This was obtained with reasonable safety and tolerability, especially when steroids are given at relatively low dose and for a period not exceeding 6 months. Recently, two randomized controlled trials have questioned the efficacy and safety of steroid therapy in IgAN. However, these trials have many drawbacks that are to be considered when interpreting the findings.

scholarly journals Chinese Herbal Medicine for Aspirin Resistance: A Systematic Review of Randomized Controlled Trials

2014 ◽  
Vol 2014 ◽  
pp. 1-16
Author(s):  
Ai-ju Liu ◽  
Hui-qin Li ◽  
Ji-huang Li ◽  
Yuan-yuan Wang ◽  
Dong Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herbal Medicine ◽  
Randomized Controlled Trials ◽  
Chinese Herbal Medicine ◽  
Aspirin Resistance ◽  
Current Evidence ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Chinese Herbal

Aspirin resistance (AR) is a prevalent phenomenon and leads to significant clinical consequences, but the current evidence for effective interventional strategy is insufficient. The objective of this systematic review is thus to assess the efficacy and safety of Chinese herbal medicine (CHM) for AR. A systematical literature search was conducted in 6 databases until December 2012 to identify randomized controlled trials (RCTs) of CHM for AR. As a result, sixteen RCTs with a total of 1011 subjects were identified, suggesting that the interests of the medical profession and the public in the use of CHM for AR have grown considerably in the recent years. Tongxinluo capsule and Danshen-based prescriptions were the most frequently used herbal prescriptions, while danshen root, milkvetch root, Leech, and Rosewood were the most frequently used single herbs. Despite the apparent reported positive findings, it is premature to determine the efficacy and safety of CHM for the treatment of AR due to poor methodological quality and insufficient safety data. However, CHMs appeared to be well tolerated in all included studies. Thus, CHM as a promising candidate is worthy of improvement and development for further clinical AR trials. Large sample-size and well-designed rigorous RCTs are needed.

scholarly journals Pharmacological treatments of Chinese herbal medicine for irritable bowel syndrome in adults: A network meta-analysis of randomized controlled trials

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255665
Author(s):  
Yun-bo Wu ◽  
Yun-kai Dai ◽  
Ling Zhang ◽  
Huai-geng Pan ◽  
Wei-jing Chen ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Herbal Medicine ◽  
Randomized Controlled Trials ◽  
Chinese Herbal Medicine ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
Irritable Bowel

Introduction Plenty of clinical studies have suggested the value of Chinese herbal medicine (CHM) for patients with irritable bowel syndrome (IBS), but their efficacy and safety have not been systematically concluded yet. This article aimed to compare and rank the therapeutic effect and safety of CHM with routine pharmacotherapies and placebo in the treatment of IBS. Methods Randomized controlled trials regarding CHM to treat IBS were searched in six databases from inception to Jan 31, 2020. A network meta-analysis was conducted to analyze the data of included publications. The quality assessment was assessed by Cochrane Handbook and GRADEpro software. The risk ratio was calculated for dichotomous outcomes while the standardized mean difference was used for continuous variables with 95% credible intervals. A Funnel plot was performed to evaluate publication bias. The surface under the cumulative ranking curve was conducted to rank the included interventions. Data were analyzed with STATA 15.0 and Review Manager 5.3. Result 3194 records were searched, and 28 eligible trials involving 3323 patients ere identified. Compared with conventional therapies and placebo, Jianpi-Chushi therapy showed significant improvement in adequate relief and IBS symptom severity scale; Shugan-Jianpi therapy showed the best efficacy in relieving the abdominal pain and abdominal distension; Wenshen-Jianpi therapy had a better effect on avoiding adverse effects and improving stool character. Conclusion This study confirmed that CHM could be beneficial for patients with IBS in relieving their clinical symptoms and should be recommended as alternative therapies. The quality of evidence in this study based on the GRADE system was “low”.

scholarly journals Comparative Efficacy and Safety of the Moxibustion for the Treatment of Coronavirus Disease 2019 (COVID-19): Protocol for a Systematic Review and Meta-analysis.

2021 ◽  
Author(s):  
Juan Gao ◽  
Xiujuan Zhou ◽  
Hongyan Xie ◽  
hong Gao ◽  
xiaoxu Fu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Eligibility Criteria ◽  
Manual Search ◽  
Acute Respiratory Insufficiency ◽  
The World ◽  
Complementary And Alternative

Abstract Background Coronavirus disease 2019 (COVID-19) has spread from its origins to the world and become a pandemic since late 2019. It predominantly damages the lungs and causes diffuse alveolar injury with edema, cellular fibroblasts and hyaline membrane formation, resulting in acute respiratory insufficiency, respiratory failure, sepsis, acute heart injury, heart failure and other severe complications. It is also reported that moxibustion can effectively modify the negative emotions and relieve the symptoms of chest distress and impaired appetite for the patient with COVID-19. The main objective of current research is to make an assessment for effectiveness and safety of the moxibustion as an important complementary and alternative therapeutic method for COVID-19.Methods and analysis Articles for the systematic literature will be located at the MEDLINE, OVID, EMBASE, CNKI, CBM, NTR, Chi CTR databases. With no restriction about language, manual search will be conducted for potential eligible articles as supplements. Any randomized controlled trials (RCTs) with any moxibustion interventions issued by the therapeutic regimen on all patients diagnosed with COVID-19 will be included. We will include the published studies with no restriction about language. All study records of the title and abstract identified by the search strategies will be directly imported and assessed based on the eligibility criteria. Risk of individual studies for the methodological quality of eligible RCTs will be assessed with the tool from the Cochrane Collaboration’s risk of bias tool.Discussion The purpose of this study is to conduct a systematic review and meta-analysis of the efficacy and safety of moxibustion as a complementary and alternative treatment for COVID-19.No studies have investigated whether moxibustion will relieve clinical symptoms and shorten the length of hospitalization time.To the best of our knowledge, this is the first systematic review and meta-analysis program designed to update the currently available evidence. Despite the fact of controversial views in using moxibustion, if this study confirms its efficacy and safety, it could provide a better guide for clinical practice around the world.Systematic review registrationPROSPERO CRD42020176572.

scholarly journals CLINICAL STUDIES ON MILD POST COVID SYNDROME WITH iWALL TABLET

2021 ◽  
Vol p5 (02) ◽  
pp. 2714-2720
Author(s):  
Naringe Yogendra Seema
Keyword(s):  
Sore Throat ◽  
Clinical Studies ◽  
Shortness Of Breath ◽  
Efficacy And Safety ◽  
The World ◽  
Entire World

COVID-19 Cases across the globe is more than 100 million. Subsets of people who have recovered from COVID-19 experience symptoms that remain even after testing negative for the virus, these set of symptoms are called Post COVID Syndrome or long COVID. Researchers all over the world are trying to deal with this disease. Ayurveda will be of great help for the entire world in dealing with this Syndrome so present study was carried out with iWALL tablet which is a polyherbal Ayurvedic formulation to see the efficacy and safety of this drug in Mild Post COVID Syndrome. In this study 25 patients with Mild Post COVID Syndrome like fatigue, myalgia, cough, sore throat and shortness of breath were treated with iWALL Tablet 750 mg two times a day for 3 month. All the data collected statistically shows significant results and study concluded that iWALL tablet is effective and safe in Mild Post COVID Syndrome.

scholarly journals The Efficacy and Safety of Traditional Chinese Medicine Tonifying-Shen (Kidney) Principle for Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-21
Author(s):  
Junquan Liang ◽  
Fengyi Wang ◽  
Jiajia Huang ◽  
Yunxiang Xu ◽  
Guizhen Chen
Keyword(s):  
Data Extraction ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Primary Osteoporosis ◽  
Efficacy And Safety ◽  
Data Synthesis ◽  
Assessment Development ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Superior Effect

Objective. This study aimed to appraise the efficacy and safety of the tonifying-Shen (kidney) principle (TS (TK) principle) for primary osteoporosis (POP). Methods. Randomized controlled clinical trials (RCTs) using the TS (TK) principle for POP were searched from eight electronic databases to search for relevant literature that was published from the initiation to September 2019. Two reviewers performed study selection, data extraction, data synthesis, and quality assessment independently. Review Manager 5.3 software was used to assess the risk of bias and conduct the data synthesis. We assessed the quality of evidence for outcomes by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Thirty-six studies with 3617 participants were included. Meta-analysis showed a consistently superior effect of the TS (TK) principle combined with conventional Western medicine (CWM) in terms of total effectiveness rates (RR = 1.28; 95% CI (1.23, 1.33); P < 0.00001 ), BMD of the lumbar spine (SMD = 0.71; 95% CI (0.47, 0.95); P < 0.00001 ) and proximal femur (SMD = 0.94; 95% CI (0.49, 1.38); P < 0.00001 ), TCM symptom integral (SMD = −1.23; 95% CI (−1.43, −1.02); P < 0.00001 ), and VAS scores (SMD = −3.88; 95% CI (−5.29, −2.46); P < 0.00001 ), when compared to using CWM alone and with significant differences. Besides, in respect of adverse effects, it showed no significant statistical difference between the experimental and control groups, RR = 0.99 and 95% CI (0.65, 1.51), P = 0.97 . Conclusion. Our meta-analysis provides promising evidence to suggest that using the TS (TK) principle combined with CWM for POP is more effective than using CWM alone. Also, both of them are safe and reliable for POP.

scholarly journals Efficacy and Safety of Traditional Chinese Herbal Medicine for Antipsychotic-Related Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 12 ◽  
Author(s):  
Wen-Wang Rao ◽  
Juan-Juan Yang ◽  
Han Qi ◽  
Sha Sha ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Response Rate ◽  
Remission Rate ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Regression Analyses ◽  
Traditional Chinese Herbal Medicine ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
Meta Regression

Background: Constipation is a common but often ignored side effect of antipsychotic treatment, although it is associated with adverse outcomes. The results of the efficacy and safety of traditional Chinese herbal medicine (TCM) in treating constipation are mixed across studies. This is a systematic review and meta-analysis of randomized controlled trials (RCTs) of the efficacy and safety of TCM compared to Western medicine (WM) in treating antipsychotic-related constipation.Methods: Major international electronic (PubMed, EMBASE, Cochrane Library, and Web of Science) and Chinese (Wanfang, WeiPu VIP, SinoMed, and CNKI) databases were searched from their inception to November 29, 2020. Meta-analysis was performed using the random-effects model.Results: Thirty RCTs with 52 arms covering 2,570 patients in the TCM group and 2,511 patients in the WM group were included. Compared with WM, TCM alone was superior regarding the moderate response rate [risk ratio (RR) = 1.165; 95% confidence interval (CI): 1.096–1.238; P &lt; 0.001], marked response rate (RR = 1.437; 95% CI: 1.267–1.692; P &lt; 0.001), and remission rate (RR = 1.376; 95% CI: 1.180–1.606; P &lt; 0.001) for constipation, while it was significantly associated with lower risk of rash (RR = 0.081; 95% CI: 0.019–0.342; P = 0.001). For the moderate response rate, meta-regression analyses revealed that publication year (β = −0.007, P = 0.0007) and Jadad score (β = 0.067, P &lt; 0.001) significantly moderated the results. For the remission rate, subgroup and meta-regression analyses revealed that the geographical region (P = 0.003), inpatient status (P = 0.035), and trial duration (β = 0.009, P = 0.013) significantly moderated the results.Conclusions: The efficacy of TCM for antipsychotic-related constipation appeared to be greater compared to WM, while certain side effects of TCM, such as rash, were less frequent.

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