scholarly journals Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Xiao Liang ◽  
ShiQiang Cheng ◽  
Jing Ye ◽  
XiaoMeng Chu ◽  
Yan Wen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fluid Intelligence ◽  
Genetic Effects ◽  
Sex Hormone ◽  
Uk Biobank ◽  
Interaction Study ◽  
Middle Aged ◽  
Bioavailable Testosterone ◽  
Gene Environment ◽  
Middle Aged Adults

Abstract Objective To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. Methods The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, gene-environment-wide interaction study (GEWIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0. Results We observed positive association between SHBG and the frequency of alcohol consumption (b = 0.0101, p = 3.84 × 10–11) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b = 0.0128, p = 1.96 × 10–8) in middle-aged males. Moreover, bioavailable testosterone was associated with the fluid intelligence (b = − 0.0136, p = 5.74 × 10–5) in middle-aged females. Finally, GEWIS identified one significant loci, Tenascin R (TNR) (rs34633780, p = 3.45 × 10–8) interacting with total testosterone for fluid intelligence. Conclusion Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.

scholarly journals Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

2020 ◽  
Author(s):  
Xiao Liang ◽  
ShiQiang Cheng ◽  
Jing Ye ◽  
XiaoMeng Chu ◽  
Yan Wen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fluid Intelligence ◽  
Genetic Effects ◽  
Sex Hormone ◽  
Uk Biobank ◽  
Interaction Study ◽  
Middle Aged ◽  
Bioavailable Testosterone ◽  
Gene Environment ◽  
Middle Aged Adults

Abstract Objective: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.Methods: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, gene-environment-wide interaction study (GEWIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.Results: We observed positive association between SHBG and the frequency of alcohol consumption (b=0.0101, p=3.84×10–11) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b=0.0128, p=1,96×10–8) in middle-aged males. Moreover, bioavailable testosterone was associated with the fluid intelligence (b=-0.0136, p=5.74×10-5) in middle-aged females. Finally, GEWIS identified one significant loci, Tenascin R (TNR) (rs34633780, p=3.45×10–8) interacting with total testosterone for fluid intelligence.Conclusion: Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.

scholarly journals Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and genome-wide genetic interaction analysis in UK Biobank cohort

2020 ◽  
Author(s):  
Xiao Liang ◽  
ShiQiang Cheng ◽  
Jing Ye ◽  
XiaoMeng Chu ◽  
Yan Wen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fluid Intelligence ◽  
Genetic Interaction ◽  
Genetic Effects ◽  
Sex Hormone ◽  
Polygenic Risk Score ◽  
Uk Biobank ◽  
Middle Aged ◽  
Genome Wide ◽  
Middle Aged Adults

Abstract Objective: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.Methods: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, genome-wide genetic interaction study (GWGIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.Results: We observed positive association between SHBG and the frequency of alcohol consumption (b=0.0101, p=3.84×10–11) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b=0.0128, p=1,96×10–8), fluid intelligence (b=0.0084, p=1.90×10–2) and the frequency of smoking (b=0.0054, p=1.77×10–2) in middle-aged males. Moreover, SHBG was associated with the frequency of alcohol consumption (b=0.0067, p=2.60×10–3), fluid intelligence (b=0.0067, p=4.25×10–2) and anxiety (b=-0.0071, p=3.79×10–2) in middle-aged females. Finally, GWGIS identified one significant loci, Tenascin R (TNR) (rs34633780, p=3.45×10–8) interacting with total testosterone for fluid intelligence.Conclusion: Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.

scholarly journals Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and genome-wide genetic interaction analysis in UK Biobank cohort

2020 ◽  
Author(s):  
Xiao Liang ◽  
ShiQiang Cheng ◽  
Jing Ye ◽  
XiaoMeng Chu ◽  
Yan Wen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fluid Intelligence ◽  
Genetic Interaction ◽  
Genetic Effects ◽  
Sex Hormone ◽  
Polygenic Risk Score ◽  
Uk Biobank ◽  
Middle Aged ◽  
Genome Wide ◽  
Middle Aged Adults

Abstract Objective: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.Methods: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, genome-wide genetic interaction study (GWGIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.Results: We observed positive association between SHBG and the frequency of alcohol consumption (b=0.0101, p=3.84×10–11) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b=0.0128, p=1,96×10–8) in middle-aged males. Moreover, SHBG was associated with the frequency of alcohol consumption (b=0.0067, p=2.60×10–3) in middle-aged females. Finally, GWGIS identified one significant loci, Tenascin R (TNR) (rs34633780, p=3.45×10–8) interacting with total testosterone for fluid intelligence.Conclusion: Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.

scholarly journals Evaluating the genetic effects of sex hormone on the development of mental traits: a polygenic score analysis and genome-wide genetic interaction analysis in the UK Biobank cohort

2020 ◽  
Author(s):  
Xiao Liang ◽  
ShiQiang Cheng ◽  
Jing Ye ◽  
XiaoMeng Chu ◽  
Yan Wen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Fluid Intelligence ◽  
Genetic Interaction ◽  
Interaction Analysis ◽  
Genetic Effects ◽  
Sex Hormone ◽  
Uk Biobank ◽  
Genome Wide ◽  
Study Results ◽  
The Uk

Abstract Objective: To evaluate the genetic effects of sex hormone on the development of mental traits.Methods: The SNPs significantly associated with sex hormone traits were driven from a two-stage genome-wide association study (GWAS). Four sex hormone were selected in this study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk scores (PRS) of sex hormone traits were calculated from individual-level genotype data of the UK Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, genome-wide genetic interaction study (GWGIS) was performed to detect novel candidate genes interacting with the sex hormone on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.Results: We observed positive associations between SHBG and the frequency of alcohol consumption (b=0.01, p=3.84×10–11) in males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b=0.01, p=1,96×10–8), fluid intelligence (b=0.01, p=1.90×10–2) and the frequency of smoking (b=0.01, p=1.77×10–2) in males. Moreover, SHBG was associated with the frequency of alcohol consumption (b=0.01, p=2.60×10–3), fluid intelligence (b=0.01, p=4.25×10–2) and anxiety (b=-0.01, p=3.79×10–2) in females. Finally, GWGIS identified one significant loci, Tenascin R (TNR) (rs34633780, p=3.45×10–8) interacting with total testosterone for fluid intelligence.Conclusion: Our study results support the genetic effects of sex hormone on the development of intelligence and the frequency of alcohol consumption.

Age Related Differences in the Strategies Used by Middle Aged Adults to Solve a Block Design Task

2005 ◽  
Vol 60 (2) ◽  
pp. 159-182 ◽  
Author(s):  
P. Rozencwajg ◽  
M. Cherfi ◽  
A. M. Ferrandez ◽  
J. Lautrey ◽  
C. Lemoine ◽  
...  
Keyword(s):  
Fluid Intelligence ◽  
Block Design ◽  
Global Strategy ◽  
Middle Aged ◽  
Design Task ◽  
Visual Spatial ◽  
Age Related ◽  
Hierarchical Stimuli ◽  
Older Subjects ◽  
Middle Aged Adults

In the present study, it was proposed to investigate the effects of aging on the strategies used to solve a block design task and to establish whether these strategies may be associated with differential patterns of ability. Two groups of subjects, 30 young adults (aged 20–35 years) and 30 middle-aged adults (aged 45–60 years) were set a computer version of the Kohs task and a battery of tests. An age-related decrease in fluid intelligence (Gf) and visual-spatial ability (Gv) was observed, along with the fact that most of the older subjects used a global strategy rather than a synthetic one. On the other hand, while continuing to use strategies of the analytic type, the older subjects looked more frequently at the model and scored high on crystallized intelligence (Gc). These findings are discussed from two different points of view: the theory of hierarchical stimuli and the hypothesis that metacognitive ability, which is thought to rely on Gc, may increase with age, and thus compensate for the loss of Gf and Gv.

Sign in / Sign up

Export Citation Format

Share Document