scholarly journals Lower vitamin D status may help explain why black women have a higher risk of invasive breast cancer than white women

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
William B. Grant
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Black Women ◽  
Invasive Breast Cancer ◽  
White Women ◽  
Vitamin D Status ◽  
Lower Vitamin

scholarly journals Mortality risk of black women and white women with invasive breast cancer by hormone receptors, HER2, and p53 status

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Huiyan Ma ◽  
Yani Lu ◽  
Kathleen E Malone ◽  
Polly A Marchbanks ◽  
Dennis M Deapen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Black Women ◽  
Mortality Risk ◽  
Invasive Breast Cancer ◽  
White Women ◽  
Hormone Receptors ◽  
P53 Status

scholarly journals High Prevalence of Vitamin D Deficiency Despite Supplementation in Premenopausal Women With Breast Cancer Undergoing Adjuvant Chemotherapy

2009 ◽  
Vol 27 (13) ◽  
pp. 2151-2156 ◽  
Author(s):  
Katherine D. Crew ◽  
Elizabeth Shane ◽  
Serge Cremers ◽  
Donald J. McMahon ◽  
Dinaz Irani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Black Women ◽  
Adjuvant Chemotherapy ◽  
Vitamin D Deficiency ◽  
White Women ◽  
Premenopausal Women ◽  
Vitamin D Supplementation ◽  
Mineral Density ◽  
Vitamin D Levels

Purpose Vitamin D deficiency is associated with increased breast cancer risk and decreased breast cancer survival. The purpose of this study was to determine the prevalence of vitamin D deficiency, as measured by serum 25-hydroxyvitamin D (25-OHD), in premenopausal women at initiation of adjuvant chemotherapy for breast cancer and after 1 year of vitamin D supplementation. Patients and Methods The study included 103 premenopausal women from the northeastern United States with stages I to III breast cancer who received adjuvant chemotherapy and participated in a 1-year zoledronate intervention trial. All patients were prescribed vitamin D3 (cholecalciferol) 400 IU and calcium carbonate 1,000 mg daily. At baseline and at 6 and 12 months, bone mineral density (BMD) measurements were obtained and blood was collected and analyzed in batches for serum 25-OHD. Vitamin D deficiency was defined as serum 25-OHD less than 20 ng/mL, insufficiency as 20 to 29 ng/mL, and sufficiency as 30 ng/mL or greater. Results At baseline, 74% of women were vitamin D deficient (median, 17 ng/mL). Vitamin D deficiency was slightly less common in white women (66%) compared with black (80%) and Hispanic (84%) women. After vitamin D supplementation for 1 year, less than 15% of white and Hispanic women, and no black women, achieved sufficient 25-OHD levels. Vitamin D levels did not correlate with baseline BMD and were not altered by chemotherapy or bisphosphonate use. Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.

Abstract 3720: Obesity and mortality among black women and white women with invasive breast cancer

2011 ◽  
Author(s):  
Yani Lu ◽  
Huiyan Ma ◽  
Kathleen E. Malone ◽  
Sandra A. Norman ◽  
Jane Sullivan-Halley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Black Women ◽  
Invasive Breast Cancer ◽  
White Women

scholarly journals Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Vanessa Dania ◽  
Ying Liu ◽  
Foluso Ademuyiwa ◽  
Jason D. Weber ◽  
Graham A. Colditz
Keyword(s):  
Breast Cancer ◽  
Black Women ◽  
Racial Differences ◽  
Invasive Breast Cancer ◽  
Hormone Receptor ◽  
Carcinoma In Situ ◽  
White Women ◽  
Lobular Carcinoma ◽  
Lobular Carcinoma In Situ

Abstract Background Lobular carcinoma in situ (LCIS) of the breast is a risk factor of developing invasive breast cancer. We evaluated the racial differences in the risks of subsequent invasive breast cancer following LCIS. Methods We utilized data from the Surveillance, Epidemiology, and End Results registries to identify 18,835 women diagnosed with LCIS from 1990 to 2015. Cox proportional hazards regression was used to estimate race/ethnicity-associated hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of subsequent invasive breast cancer. Results During a median follow-up of 90 months, 1567 patients developed invasive breast cancer. The 10-year incidence was 7.9% for Asians, 8.2% for Hispanics, 9.3% for whites, and 11.2% for blacks (P = 0.046). Compared to white women, black women had significantly elevated risks of subsequent invasive breast cancer (HR 1.33; 95% CI 1.11, 1.59), and invasive cancer in the ipsilateral breast (HR 1.37; 95% CI 1.08, 1.72) and in the contralateral breast (HR 1.33; 95% CI 1.00, 1.76). Black women had significantly higher risks of invasive subtypes negative for both estrogen receptor and progesterone receptor (HR 1.86; 95% CI 1.14, 3.03) and invasive subtypes positive for one or both of receptors (HR 1.30; 95% CI 1.07, 1.59). The risk of subsequent invasive breast cancer was comparable in Asian women and Hispanic women compared with white women. Conclusions Black women had a significantly higher risk of developing invasive breast cancer, including both hormone receptor-positive and hormone receptor-negative subtypes, after LCIS compared with white counterparts. It provides an opportunity to address health disparities.

scholarly journals Pre-diagnosis alcohol consumption and mortality risk among black women and white women with invasive breast cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Huiyan Ma ◽  
Kathleen E. Malone ◽  
Jill A. McDonald ◽  
Polly A. Marchbanks ◽  
Giske Ursin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Black Women ◽  
Alcohol Consumption ◽  
Mortality Risk ◽  
Invasive Breast Cancer ◽  
White Women

scholarly journals Obesity and Survival Among Black Women and White Women 35 to 64 Years of Age at Diagnosis With Invasive Breast Cancer

2011 ◽  
Vol 29 (25) ◽  
pp. 3358-3365 ◽  
Author(s):  
Yani Lu ◽  
Huiyan Ma ◽  
Kathleen E. Malone ◽  
Sandra A. Norman ◽  
Jane Sullivan-Halley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Black Women ◽  
Invasive Breast Cancer ◽  
White Women ◽  
Cox Regression ◽  
Adjusted Relative Risk ◽  
Risk Of Death ◽  
Black Patients ◽  
Cancer Specific Mortality

Purpose To evaluate the effect of obesity on survival among black women and white women with invasive breast cancer and to determine whether obesity explains the poorer survival of black women relative to white women. Patients and Methods We observed 4,538 (1,604 black, 2,934 white) women who were 35 to 64 years of age when diagnosed with incident invasive breast cancer between 1994 and 1998. Multivariate Cox regression models were used to examine the effect of body mass index (BMI, in kilograms per square meter) 5 years before diagnosis on risk of death from any cause and from breast cancer. Results During a median of 8.6 years of follow-up, 1,053 women died (519 black, 534 white), 828 as a result of breast cancer (412 black, 416 white). Black women were more likely to die than white women (multivariate-adjusted relative risk [RR], 1.33; 95% CI, 1.16 to 1.53). Compared with women with BMI of 20 to 24.9 kg/m2, those who were obese (BMI ≥ 30 kg/m2) had a greater risk of all-cause mortality (RR, 1.23; 95% CI, 1.04 to 1.47) and breast cancer–specific mortality (RR, 1.20; 95% CI, 0.99 to 1.46). These associations were observed among white women (all-cause RR, 1.54; 95% CI, 1.21 to 1.96; breast cancer RR, 1.46; 95% CI, 1.11 to 1.92), but not among black women (all-cause RR, 1.03; 95% CI, 0.81 to 1.29; breast cancer RR, 1.02; 95% CI, 0.79 to 1.33). Conclusion Obesity may play an important role in mortality among white but not black patients with breast cancer. It is unlikely that differences in obesity distributions between black women and white women account for the poorer survival of black women.

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