Early screening for Chlamydia trachomatis in young women for primary prevention of pelvic inflammatory disease (i-Predict): study protocol for a randomised controlled trial

Pelvic inflammatory disease (PID) is a frequent condition of young women, often resulting in reproductive morbidity. Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are/is recovered from approximately a third to a half of women with PID, the etiologic agent is often unidentified. We need PCR to test for M genitalium among a pilot sample of 50 women with nongonococcal, nonchlamydial endometritis enrolled in the PID evaluation and clinical health (PEACH) study. All participants had pelvic pain, pelvic organ tenderness, and leukorrhea, mucopurulent cervicitis, or untreated cervicitis. Endometritis was defined as≥5 surface epithelium neutrophils per×400field absent of menstrual endometrium and/or≥2 stromal plasma cells per×120field. We detected M genitalium in 7 (14%) of the women tested: 6 (12%) in cervical specimens and 4 (8%) in endometrial specimens. We conclude that M genitalium is prevalent in the endometrium of women with nongonococcal, nonchlamydial PID.

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A multicentre randomised controlled trial of levetiracetam versus phenytoin for convulsive status epilepticus in children (protocol): Convulsive Status Epilepticus Paediatric Trial (ConSEPT) - a PREDICT study

BMC Pediatrics ◽

10.1186/s12887-017-0887-8 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 12

Author(s):

Stuart R. Dalziel ◽

◽

Jeremy Furyk ◽

Megan Bonisch ◽

Ed Oakley ◽

...

Keyword(s):

Status Epilepticus ◽

Randomised Controlled Trial ◽

Controlled Trial ◽

Convulsive Status Epilepticus ◽

Paediatric Trial ◽

Randomised Controlled ◽

Predict Study

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Impact of screening for risk of suicide: randomised controlled trial

The British Journal of Psychiatry ◽

10.1192/bjp.bp.110.083592 ◽

2011 ◽

Vol 198 (5) ◽

pp. 379-384 ◽

Cited By ~ 42

Author(s):

Mike J. Crawford ◽

Lavanya Thana ◽

Caroline Methuen ◽

Pradip Ghosh ◽

Sian V. Stanley ◽

...

Keyword(s):

Primary Care ◽

Suicidal Ideation ◽

Randomised Controlled Trial ◽

Controlled Trial ◽

Secondary Outcome ◽

Worth Living ◽

Early Screening ◽

Care Services ◽

Randomised Controlled ◽

The Impact

BackgroundConcerns have been expressed about the impact that screening for risk of suicide may have on a person's mental health.AimsTo examine whether screening for suicidal ideation among people who attend primary care services and have signs of depression increases the short-term incidence of feeling that life is not worth living.MethodIn a multicentre, single-blind, randomised controlled trial, 443 patients in four general practices were randomised to screening for suicidal ideation or control questions on health and lifestyle (trial registration: ISRCTN84692657). The primary outcome was thinking that life is not worth living measured 10–14 days after randomisation. Secondary outcome measures comprised other aspects of suicidal ideation and behaviour.ResultsA total of 443 participants were randomised to early (n = 230) or delayed screening (n = 213). Their mean age was 48.5 years (s.d. = 18.4, range 16–92) and 137 (30.9%) were male. The adjusted odds of experiencing thoughts that life was not worth living at follow-up among those randomised to early compared with delayed screening was 0.88 (95% CI 0.66–1.18). Differences in secondary outcomes between the two groups were not seen. Among those randomised to early screening, 37 people (22.3%) reported thinking about taking their life at baseline and 24 (14.6%) that they had this thought 2 weeks later.ConclusionsScreening for suicidal ideation in primary care among people who have signs of depression does not appear to induce feelings that life is not worth living.

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Results of the PReDicT Study: A Randomised Controlled Trial of Using the PReDicT Test to Guide Antidepressant Treatment in Depression

Biological Psychiatry ◽

10.1016/j.biopsych.2020.02.155 ◽

2020 ◽

Vol 87 (9) ◽

pp. S51

Author(s):

Michael Browning

Keyword(s):

Randomised Controlled Trial ◽

Antidepressant Treatment ◽

Controlled Trial ◽

Randomised Controlled ◽

Predict Study

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Cluster randomised controlled trial to determine the effect of peer delivery HIV self-testing to support linkage to HIV prevention among young women in rural KwaZulu-Natal, South Africa: a study protocol

BMJ Open ◽

10.1136/bmjopen-2019-033435 ◽

2019 ◽

Vol 9 (12) ◽

pp. e033435

Author(s):

Oluwafemi Atanda Adeagbo ◽

Nondumiso Mthiyane ◽

Carina Herbst ◽

Paul Mee ◽

Melissa Neuman ◽

...

Keyword(s):

South Africa ◽

Randomised Controlled Trial ◽

Young Women ◽

Controlled Trial ◽

Cluster Randomised Controlled Trial ◽

Peer Networks ◽

Cluster Randomised ◽

Self Testing ◽

Kwazulu Natal ◽

Randomised Controlled

IntroductionA cluster randomised controlled trial (cRCT) to determine whether HIV self-testing (HIVST) delivered by peers either directly or through incentivised peer-networks, could increase the uptake of antiretroviral therapy and pre-exposure prophylaxis (PrEP) among young women (18 to 24 years) is being undertaken in an HIV hyperendemic area in KwaZulu-Natal, South Africa.Methods and analysisA three-arm cRCT started mid-March 2019, in 24 areas in rural KwaZulu-Natal. Twenty-four pairs of peer navigators working with ~12 000 young people aged 18 to 30 years over a period of 6 months were randomised to: (1) incentivised-peer-networks: peer-navigators recruited participants ‘seeds’ to distribute up to five HIVST packs and HIV prevention information to peers within their social networks. Seeds receive an incentive (20 Rand = US$1.5) for each respondent who contacts a peer-navigator for additional HIVST packs to distribute; (2) peer-navigator-distribution: peer-navigators distribute HIVST packs and information directly to young people; (3) standard of care: peer-navigators distribute referral slips and information. All arms promote sexual health information and provide barcoded clinic referral slips to facilitate linkage to HIV testing, prevention and care services. The primary outcome is the difference in linkage rate between arms, defined as the number of women (18 to 24 years) per peer-navigators month of outreach work (/pnm) who linked to clinic-based PrEP eligibility screening or started antiretroviral, based on HIV-status, within 90 days of receiving the clinic referral slip.Ethics and disseminationThis study was approved by the Institutional Review Boards at the WHO, Switzerland (Protocol ID: STAR CRT, South Africa), London School of Hygiene and Tropical Medicine, UK (Reference: 15 990–1), University of KwaZulu-Natal (BFC311/18) and the KwaZulu-Natal Department of Health (Reference: KZ_201901_012), South Africa. The findings of this trial will be disseminated at local, regional and international meetings and through peer-reviewed publications.Trial registration numberNCT03751826; Pre-results.

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