scholarly journals Correction to: Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
Aurélie Najm ◽  
◽  
Benoît Le Goff ◽  
Carl Orr ◽  
Rogier Thurlings ◽  
...  
Keyword(s):  
Synovial Tissue ◽  
Rheumatic Diseases ◽  
Synovial Biopsy ◽  
Tissue Biopsy

Synovial Tissue Biopsy in the Diagnosis of Rheumatic Diseases

1964 ◽  
Vol 35 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Jacques Houli ◽  
Boris Klein ◽  
Anibal Pires ◽  
Claudio Lemos
Keyword(s):  
Synovial Tissue ◽  
Rheumatic Diseases ◽  
Tissue Biopsy

The 2018 OMERACT Synovial Tissue Biopsy Special Interest Group Report on Standardization of Synovial Biopsy Analysis

2019 ◽  
Vol 46 (10) ◽  
pp. 1365-1368 ◽  
Author(s):  
Mihir D. Wechalekar ◽  
Aurélie Najm ◽  
Douglas J. Veale ◽  
Vibeke Strand
Keyword(s):  
Rheumatoid Arthritis ◽  
Retrospective Study ◽  
Synovial Tissue ◽  
Multicenter Study ◽  
Delphi Survey ◽  
Disease Modifying Antirheumatic Drugs ◽  
Antirheumatic Drugs ◽  
Tissue Biopsy ◽  
Group Report ◽  
Disease Modifying

Objective.The Outcome Measures in Rheumatology (OMERACT) synovial tissue biopsy (STB) working group initiated an international effort to standardize STB analyses, define consensual items to inform treatment choices, and predict responses in rheumatoid arthritis (RA).Methods.(1) A Delphi survey to determine items for STB analyses. (2) A multicenter retrospective study of STB data in patients with RA posttreatment with biological disease-modifying antirheumatic drugs.Results.The Delphi survey identified 18 STB analyses items. Consensus on histological markers was achieved in the OMERACT 2018 SIG.Conclusion.Six markers were identified for examination in a multicenter study designed to define an OMERACT-endorsed set of STB markers to predict responses to treatment.

Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

2010 ◽  
Vol 70 (3) ◽  
pp. 423-427 ◽  
Author(s):  
Marleen G H van de Sande ◽  
Danielle M Gerlag ◽  
Beatrijs M Lodde ◽  
Lisa G M van Baarsen ◽  
Stefano Alivernini ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Translational Research ◽  
Synovial Tissue ◽  
Therapeutic Targets ◽  
Synovial Biopsy ◽  
Prognostic Biomarkers

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.

Synovial biopsies

2020 ◽  
pp. 169-176
Author(s):  
Douglas J. Veale ◽  
Ursula Fearon
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Tissue ◽  
Disease Outcome ◽  
Response To Treatment ◽  
Significant Progress ◽  
Rheumatoid Arthritis Pathogenesis ◽  
Tissue Biopsy ◽  
Small Needle ◽  
Primary Tissue

Synovial tissue is the primary tissue inflamed in rheumatoid arthritis. Initial studies of synovial biopsies were obtained during arthroplasty or using a needle to biopsy the joint percutaneously. Recently, small needle arthroscopy or ultrasonography guided techniques have become more widely available to visualize and reliably obtain synovial biopsies. These techniques have allowed significant progress in the study of rheumatoid arthritis pathogenesis, even at the earliest stages of disease. Currently, research efforts are underway to use synovial biopsies to identify patients and to discover biomarkers that will enable clinicians to predict the course of the disease and perhaps to identify more appropriately the correct therapy for patients with rheumatoid arthritis. In this chapter, we describe the advances in synovial tissue biopsy research and how it has improved our knowledge of rheumatoid arthritis pathogenesis, informed our understanding of possible biomarkers for diagnosis and stratification, and potentially may aid in the prediction of disease outcome and response to treatment.

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