scholarly journals Characterization of the cytolethal distending toxin (typhoid toxin) in non-typhoidal Salmonella serovars

Gut Pathogens ◽  
2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Lorraine D Rodriguez-Rivera ◽  
Barbara M Bowen ◽  
Henk C den Bakker ◽  
Gerald E Duhamel ◽  
Martin Wiedmann
Keyword(s):  
Cytolethal Distending Toxin ◽  
Salmonella Serovars ◽  
Typhoid Toxin

scholarly journals Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies

2020 ◽  
Vol 88 (10) ◽  
Author(s):  
Xuyao Jiao ◽  
Sarah Smith ◽  
Gabrielle Stack ◽  
Qi Liang ◽  
Allan Bradley ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Typhoid Fever ◽  
Severe Disease ◽  
Genetically Engineered ◽  
Human Monoclonal Antibodies ◽  
Genetically Engineered Mice ◽  
Typhoid Toxin

ABSTRACT Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of PltB or PltC. Here, we describe the generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies by immunizing genetically engineered mice that have a full set of human immunoglobulin variable region genes. We identified several monoclonal antibodies with strong in vitro and in vivo toxin-neutralizing activity and different mechanisms of toxin neutralization. These antibodies could serve as the basis for the development of novel therapeutic strategies against typhoid fever.

scholarly journals Molecular characterization of cytolethal distending toxin gene-positive Escherichia coli from healthy cattle and swine in Nara, Japan

2014 ◽  
Vol 14 (1) ◽  
pp. 97 ◽  
Author(s):  
Atsushi Hinenoya ◽  
Kensuke Shima ◽  
Masahiro Asakura ◽  
Kazuhiko Nishimura ◽  
Teizo Tsukamoto ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Molecular Characterization ◽  
Toxin Gene ◽  
Cytolethal Distending Toxin ◽  
Healthy Cattle

The characterization of Salmonella serovars isolated from apparently healthy slaughtered pigs at Addis Ababa abattoir, Ethiopia

2007 ◽  
Vol 82 (3-4) ◽  
pp. 252-261 ◽  
Author(s):  
K. Aragaw ◽  
B. Molla ◽  
A. Muckle ◽  
L. Cole ◽  
E. Wilkie ◽  
...  
Keyword(s):  
Addis Ababa ◽  
Salmonella Serovars ◽  
Slaughtered Pigs ◽  
Apparently Healthy

scholarly journals Characterization of Cytolethal Distending Toxin of Campylobacter Species Isolated from Captive Macaque Monkeys

2005 ◽  
Vol 43 (2) ◽  
pp. 641-649 ◽  
Author(s):  
R. P. Dassanayake ◽  
Y. Zhou ◽  
S. Hinkley ◽  
C. J. Stryker ◽  
G. Plauche ◽  
...  
Keyword(s):  
Cytolethal Distending Toxin ◽  
Macaque Monkeys ◽  
Campylobacter Species

Prevalence and characterization of Salmonella serovars in retail meats of marketplace in Shaanxi, China

2010 ◽  
Vol 141 (1-2) ◽  
pp. 63-72 ◽  
Author(s):  
Baowei Yang ◽  
Dong Qu ◽  
Xiuli Zhang ◽  
Jinling Shen ◽  
Shenghui Cui ◽  
...  
Keyword(s):  
Retail Meats ◽  
Salmonella Serovars
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