Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice

Helen Crehan; Bin Liu; Martin Kleinschmidt; Jens-Ulrich Rahfeld; Kevin X. Le; Barbara J. Caldarone; Jeffrey L. Frost; Thore Hettmann; Birgit Hutter-Paier; Brian O’Nuallain; Mi-Ae Park; Marcelo F. DiCarli; Inge Lues; Stephan Schilling; Cynthia A. Lemere

doi:10.1186/s13195-019-0579-8

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice

Alzheimer s Research & Therapy ◽

10.1186/s13195-019-0579-8 ◽

2020 ◽

Vol 12 (1) ◽

Cited By ~ 2

Author(s):

Helen Crehan ◽

Bin Liu ◽

Martin Kleinschmidt ◽

Jens-Ulrich Rahfeld ◽

Kevin X. Le ◽

...

Keyword(s):

Effector Function ◽

Glial Activation ◽

Cognitive Benefit

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Faculty Opinions recommendation of Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014310.370905 ◽

2006 ◽

Author(s):

Mary Carrington

Keyword(s):

Natural Killer Cell ◽

Natural Killer ◽

Killer Cell ◽

Effector Function ◽

Cell Repertoire ◽

Repertoire Selection

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Faculty Opinions recommendation of Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024193.287780 ◽

2005 ◽

Author(s):

Eric Long

Keyword(s):

T Cells ◽

T Cell ◽

T Cell Receptor ◽

Lipid Raft ◽

Actin Polymerization ◽

Cell Receptor ◽

Effector Function

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Faculty Opinions recommendation of Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1165800.627442 ◽

2009 ◽

Author(s):

Helene Rosenberg

Keyword(s):

Effector Function ◽

Th2 Cells

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Faculty Opinions recommendation of Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13154962.14486062 ◽

2011 ◽

Author(s):

Bart Roep

Keyword(s):

T Cell ◽

Cd8 T Cell ◽

Effector Function ◽

Tetramer Staining ◽

Cell Effector Function ◽

Cell Effector

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Faculty Opinions recommendation of Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4615956.4493054 ◽

2010 ◽

Author(s):

I-Cheng Ho

Keyword(s):

Transcription Factor ◽

T Lymphocytes ◽

Clonal Expansion ◽

Effector Function ◽

Cd8 T Lymphocytes

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Faculty Opinions recommendation of Posttranscriptional control of T cell effector function by aerobic glycolysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718022061.793479189 ◽

2013 ◽

Author(s):

George Yap

Keyword(s):

T Cell ◽

Aerobic Glycolysis ◽

Effector Function ◽

Posttranscriptional Control ◽

Cell Effector Function ◽

Cell Effector

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Faculty Opinions recommendation of Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718077548.793484498 ◽

2013 ◽

Author(s):

Thomas Huenig

Keyword(s):

T Cells ◽

Cd8 T Cells ◽

Effector Function ◽

Immediate Early ◽

Memory Cd8 T Cells

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Faculty Opinions recommendation of Glial activation and segmental upregulation of interleukin-1beta (IL-1beta) in the rat spinal cord after surgical incision.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.722294502.471385 ◽

2006 ◽

Author(s):

Claudia Sommer

Keyword(s):

Spinal Cord ◽

Glial Activation ◽

Rat Spinal Cord ◽

Surgical Incision ◽

Interleukin 1Beta

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Faculty Opinions recommendation of Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732439267.793543523 ◽

2018 ◽

Author(s):

Larry Kane

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Effector Function ◽

T Helper ◽

Helper Type

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Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis

Journal of Neuroimmune Pharmacology ◽

10.1007/s11481-010-9243-6 ◽

2010 ◽

Vol 6 (3) ◽

pp. 354-361 ◽

Cited By ~ 75

Author(s):

Unsong Oh ◽

Masahiro Fujita ◽

Vasiliki N. Ikonomidou ◽

Iordanis E. Evangelou ◽

Eiji Matsuura ◽

...

Keyword(s):

Multiple Sclerosis ◽

Pet Imaging ◽

Glial Activation ◽

Translocator Protein

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