scholarly journals Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Nicolas Lanthier ◽  
Nathalie Lin-Marq ◽  
Laura Rubbia-Brandt ◽  
Sophie Clément ◽  
Nicolas Goossens ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Liver Disease ◽  
Cell Transplantation ◽  
Alcoholic Liver Disease ◽  
Expression Patterns ◽  
Autologous Bone Marrow ◽  
Gene Expression Patterns ◽  
Autologous Bone ◽  
The Impact

scholarly journals Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism

2021 ◽  
Author(s):  
Michael V. Lombardo ◽  
Elena Maria Busuoli ◽  
Laura Schreibman ◽  
Aubyn C. Stahmer ◽  
Tiziano Pramparo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Treatment Outcome ◽  
Early Intervention ◽  
Developmental Change ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Time In Treatment ◽  
Pre Treatment ◽  
Blood Leukocyte ◽  
The Impact

AbstractEarly detection and intervention are believed to be key to facilitating better outcomes in children with autism, yet the impact of age at treatment start on the outcome is poorly understood. While clinical traits such as language ability have been shown to predict treatment outcome, whether or not and how information at the genomic level can predict treatment outcome is unknown. Leveraging a cohort of toddlers with autism who all received the same standardized intervention at a very young age and provided a blood sample, here we find that very early treatment engagement (i.e., <24 months) leads to greater gains while controlling for time in treatment. Pre-treatment clinical behavioral measures predict 21% of the variance in the rate of skill growth during early intervention. Pre-treatment blood leukocyte gene expression patterns also predict the rate of skill growth, accounting for 13% of the variance in treatment slopes. Results indicated that 295 genes can be prioritized as driving this effect. These treatment-relevant genes highly interact at the protein level, are enriched for differentially histone acetylated genes in autism postmortem cortical tissue, and are normatively highly expressed in a variety of subcortical and cortical areas important for social communication and language development. This work suggests that pre-treatment biological and clinical behavioral characteristics are important for predicting developmental change in the context of early intervention and that individualized pre-treatment biology related to histone acetylation may be key.

Safety of Autologous Bone Marrow Stromal Cell Transplantation in Dogs with Acute Spinal Cord Injury

2012 ◽  
Vol 41 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Hidetaka Nishida ◽  
Masanari Nakayama ◽  
Hiroshi Tanaka ◽  
Masahiko Kitamura ◽  
Shingo Hatoya ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Autologous Bone Marrow ◽  
Marrow Stromal Cell ◽  
Cord Injury ◽  
Autologous Bone
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