A protocol for a systematic literature review of economic evaluation studies of interventions to address antimicrobial resistance

Abstract Background Antimicrobial resistance (AMR) is accelerated by the widespread and often indiscriminate use of antimicrobials in humans, animals, and the environment. In 2015, the World Health Organization recognised AMR as one of the top ten global health threats, due to its potential to neutralise humanity’s advancements in western medicine by enabling the emergence of new strains of existing pathogens, many of which have no available treatments. Over the past decade, several countries, including those in low- and middle-income contexts, have started implementing interventions to tackle AMR. However, economic evidence regarding the cost-effectiveness of these interventions remains weak. To address this evidence gap, we will conduct a systematic literature review to provide a comprehensive summary on the value for money of different AMR interventions. Methods We aim to conduct a systematic literature review of all available economic evaluations on interventions addressing AMR and will provide a narrative synthesis of our findings. Systematic searches for relevant studies will be performed across all suitable databases as well as in grey literature sources such as unpublished studies, reports, and other relevant documents. All economic evaluation studies will be included as long as they report an economic outcome and have stated that the analysed intervention will reduce antimicrobial resistance or antimicrobial use in the abstract. Those studies reporting clinical endpoints alone will be excluded. Selection for final inclusion and data extraction will be performed by two independent reviewers. Discussion The review will be one of the first of its kind, and the most recent, to systematically review literature on the cost-effectiveness of AMR interventions, an important evidence gap in the economics of AMR. The findings will enable policy and decision-makers, particularly in resource-constrained settings, to better use available resources when selecting interventions to address AMR burdens, Systematic review registration PROSPERO CRD42020190310

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A Protocol for a Systematic Literature Review of Economic Evaluation Studies of Interventions to Address Antimicrobial Resistance

10.21203/rs.3.rs-109561/v1 ◽

2020 ◽

Author(s):

Aparna Ananthakrishnan ◽

Chris Painter ◽

Yot Teerawattananon

Keyword(s):

Economic Evaluation ◽

Cost Effectiveness ◽

Antimicrobial Resistance ◽

Literature Review ◽

Systematic Literature Review ◽

Evaluation Studies ◽

Grey Literature ◽

World Health ◽

Economic Evaluations ◽

The Cost

Abstract Background: Antimicrobial resistance (AMR) is accelerated by the widespread and often indiscriminate use of antimicrobials in humans, animals, and the environment. In 2015, the World Health Organization recognised AMR as one of the top ten global health threats, due to its potential to neutralise humanity’s advancements in western medicine by enabling the emergence of new strains of existing pathogens, many of which have no available treatments. Over the past decade, several countries, including those in low- and middle- income contexts, have started implementing interventions to tackle AMR. However, economic evidence regarding the cost-effectiveness of these interventions remain weak. To address this evidence gap, we will conduct a systematic literature review to provide a comprehensive summary on the value for money of different AMR interventions.Methods: We aim to conduct a systematic literature review of all available economic evaluations on interventions addressing AMR and will provide a narrative synthesis of our findings. Systematic searches for relevant studies will be performed across all suitable databases as well as in grey literature sources such as unpublished studies, reports, and other relevant documents. All economic evaluation studies will be included as long as they report an economic outcome. Those studies reporting clinical endpoints alone will be excluded. Selection for final inclusion and data extraction will be performed by two independent reviewers. Discussion: The review will be one of the first of its kind, and the most recent, to systematically review literature on the cost-effectiveness of AMR interventions, an important evidence gap in the economics of AMR. The findings will enable policy and decision-makers, particularly in resource-constrained settings, to better use available resources when selecting interventions to address AMR burdens, Systematic review registration: PROSPERO (Awaiting registration number)

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The Cost-Effectiveness of Mobile Health (mHealth) Interventions for Older Adults: Systematic Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17155290 ◽

2020 ◽

Vol 17 (15) ◽

pp. 5290

Author(s):

Zartashia Ghani ◽

Johan Jarl ◽

Johan Sanmartin Berglund ◽

Martin Andersson ◽

Peter Anderberg

Keyword(s):

Older Adults ◽

Economic Evaluation ◽

Cost Effectiveness ◽

Empirical Evidence ◽

Mobile Health ◽

Evaluation Studies ◽

Health Economic Evaluation ◽

Reporting Quality ◽

Economic Evaluations ◽

The Cost

The objective of this study was to critically assess and review empirical evidence on the cost-effectiveness of Mobile Health (mHealth) interventions for older adults. We systematically searched databases such as Pubmed, Scopus, and Cumulative Index of Nursing and Allied Literature (CINAHL) for peer-reviewed economic evaluations published in English from 2007 to 2018. We extracted data on methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and assessed if this evidence supported the reported findings in terms of cost-effectiveness. The consolidated health economic evaluation reporting standards (CHEERS) checklist was used to assess the reporting quality of the included studies. Eleven studies were identified and categorized into two groups: complex smartphone communication and simple text-based communication. Substantial heterogeneity among the studies in terms of methodological approaches and types of intervention was observed. The cost-effectiveness of complex smartphone communication interventions cannot be judged due to lack of information. Limited evidence of cost-effectiveness was found for interventions related to simple text-based communications. Comprehensive economic evaluation studies are warranted to assess the cost-effectiveness of mHealth interventions designed for older adults.

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PDB65 - THE COST-EFFECTIVENESS OF METFORMIN IN PRE-DIABETICS: A SYSTEMATIC LITERATURE REVIEW OF HEALTH ECONOMIC EVALUATIONS

Value in Health ◽

10.1016/j.jval.2018.09.770 ◽

2018 ◽

Vol 21 ◽

pp. S129

Author(s):

S. Gebregergish ◽

A. Henry ◽

M. Hashim ◽

B. Heeg ◽

T. Wilke ◽

...

Keyword(s):

Health Economic ◽

Cost Effectiveness ◽

Literature Review ◽

Systematic Literature Review ◽

Economic Evaluations ◽

The Cost

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Economic Evaluations of Organ Transplantations - A Systematic Literature Review

Nordic Journal of Health Economics ◽

10.5617/njhe.168 ◽

2011 ◽

Vol 1 (1) ◽

Cited By ~ 4

Author(s):

Johan Jarl ◽

Ulf-G. Gerdtham

Keyword(s):

Cost Effectiveness ◽

Small Bowel ◽

Literature Review ◽

Organ Transplantation ◽

Systematic Literature Review ◽

Sample Selection ◽

Economic Evaluations ◽

Future Studies ◽

Study Characteristics ◽

The Cost

The purpose of this study is threefold; 1) to establish the current level of knowledge regarding cost-effectiveness of organ transplantation, 2) to identify knowledge gaps, and 3) to suggest a framework for future studies. A systematic literature review of economic evaluations of transplantations of solid organs was conducted in October 2010. Economic evaluations published since 2000 and reviews published since 1987 for kidney, liver, lung, heart, pancreas, and small bowel transplantations were collected. The studies were analysed regarding results and study characteristics. The review demonstrates a lack of economic evaluations for all included organ transplantations. The cost-effectiveness of kidney transplantation, and to some extent liver transplantation, compared to a non-transplant alternative appears to be established. However, cost-effectiveness for transplantation of lung, heart, pancreas, and small bowel can neither be established nor rejected based on earlier studies. Many of the included studies were limited in a number of ways; e.g. using short follow-up period, failing to account for sample selection in treatment groups, comparing to unrealistic alternatives, lacking important cost categories, and using a limiting perspective. Recommendation for future studies are, besides accounting for the above, to conduct sub-group analyses as patient and disease characteristics, among other things, has been shown to affect the cost-effectiveness of organ transplantation. Link to Appendix

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The cost-effectiveness of metformin in pre-diabetics: a systematic literature review of health economic evaluations

Expert Review of Pharmacoeconomics & Outcomes Research ◽

10.1080/14737167.2020.1688146 ◽

2019 ◽

Vol 20 (2) ◽

pp. 207-219

Author(s):

Samron Brhane Gebregergish ◽

Mahmoud Hashim ◽

Bart Heeg ◽

Thomas Wilke ◽

Marco Rauland ◽

...

Keyword(s):

Health Economic ◽

Cost Effectiveness ◽

Literature Review ◽

Systematic Literature Review ◽

Economic Evaluations ◽

The Cost

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The cost-effectiveness of follow-up strategies after cancer treatment: a systematic literature review

British Medical Bulletin ◽

10.1093/bmb/ldy011 ◽

2018 ◽

Vol 126 (1) ◽

pp. 85-100 ◽

Cited By ~ 3

Author(s):

M Barbieri ◽

G Richardson ◽

S Paisley

Keyword(s):

Breast Cancer ◽

Cost Effectiveness ◽

Literature Review ◽

Cancer Patients ◽

Systematic Literature Review ◽

Colorectal Disease ◽

Economic Evaluations ◽

Cancer Type ◽

The Cost

Abstract Introduction The cost of treatment and follow-up of cancer patients in the UK is substantial. In a budget-constrained system such as the NHS, it is necessary to consider the cost-effectiveness of the range of management strategies at different points on cancer patients’ care pathways to ensure that they provide adequate value for money. Sources of data We conducted a systematic literature review to explore the cost-effectiveness of follow-up strategies of patients previously treated for cancer with the aim of informing UK policy. All papers that were considered to be economic evaluations in the subject areas described above were extracted. Areas of agreement The existing literature suggests that intensive follow-up of patients with colorectal disease is likely to be cost-effective, but the opposite holds for breast cancer. Areas of controversy Interventions and strategies for follow-up in cancer patients were variable across type of cancer and setting. Drawing general conclusions about the cost-effectiveness of these interventions/strategies is difficult. Growing points The search identified 2036 references but applying inclusion/exclusion criteria a total of 44 articles were included in the analysis. Breast cancer was the most common (n = 11) cancer type followed by colorectal (n = 10) cancer. In general, there were relatively few studies of cost-effectiveness of follow-up that could influence UK guidance. Where there was evidence, in the most part, NICE guidance broadly reflected this evidence. Areas timely to develop research In terms of future research around the timing, frequency and composition of follow-ups, this is dependent on the type of cancer being considered. Nevertheless, across most cancers, the possibility of remote follow-up (or testing) by health professionals other than hospital consultants in other settings appears to warrant further work.

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Economic evaluations of health care interventions in Oropharyngeal Dysphagia after Stroke: Protocol for a Systematic Review.

10.21203/rs.3.rs-376486/v1 ◽

2021 ◽

Author(s):

Sergio Marin ◽

Mateu Serra-Prat ◽

Omar Ortega ◽

Pere Clavé

Keyword(s):

Systematic Review ◽

Economic Evaluation ◽

Cost Effectiveness ◽

Oropharyngeal Dysphagia ◽

Cost Savings ◽

Economic Evaluations ◽

Stroke Patients ◽

Post Stroke ◽

Healthcare Interventions ◽

The Cost

Abstract Background and purpose: Oropharyngeal Dysphagia (OD) affects 40-81% of patients after stroke. A recent systematic review on the costs of OD and it’s main complications showed higher acute and long-term costs for those patients who developed OD, malnutrition and pneumonia after stroke. These results suggest that appropriate management of post-stroke OD could lead to reduction of clinical complications and significant cost savings. The purpose of this systematic review is to assess the available literature exploring the efficiency or cost-effectiveness of available healthcare interventions on the appropriate management of OD. Methods: A systematic review on economic evaluations of health care interventions on post-stroke patients with OD following PRISMA recommendations will be performed. MEDLINE, Embase, the National Health Service Economic Evaluation Database and the Cost-Effectiveness Analysis Registry Database will be searched and a subsequent reference check will be done. English and Spanish literature will be included without date restrictions. Studies will be included if they refer to economic evaluations or studies in which cost savings were reported in post-stroke patients suffering OD. Studies will be excluded if they are partial economic evaluation studies, if they refer to esophageal dysphagia, or if OD is caused by causes different from stroke. Evidence will be presented and synthetized with a narrative method and using tables. Quality evaluation will be done using Consolidated Health Economic Evaluation Reporting Standards (CHEERS) Statement. Discussion: The protocol for this systematic review is the first step to assess the cost-effectiveness of the healthcare interventions that have been described as potential treatments for post-stroke OD. This systematic review will summarize the current evidence on the relation between cost and benefits associated with the appropriate management of OD in post-stroke patients. Systematic review registration: PROSPERO CRD42020136245

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A Systematic Review of Methods, Study Quality, and Results of Economic Evaluation for Childhood and Adolescent Obesity Intervention

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16030485 ◽

2019 ◽

Vol 16 (3) ◽

pp. 485 ◽

Cited By ~ 3

Author(s):

Mandana Zanganeh ◽

Peymane Adab ◽

Bai Li ◽

Emma Frew

Keyword(s):

Systematic Review ◽

Economic Evaluation ◽

Cost Effectiveness ◽

Evidence Synthesis ◽

Evaluation Studies ◽

Cost Effective ◽

Adolescent Obesity ◽

Economic Evaluations ◽

Full Economic Evaluation ◽

Childhood And Adolescent Obesity

Many suggested policy interventions for childhood and adolescent obesity have costs and effects that fall outside the health care sector. These cross-sectorial costs and consequences have implications for how economic evaluation is applied and although previous systematic reviews have provided a summary of cost-effectiveness, very few have conducted a review of methods applied. We undertook this comprehensive review of economic evaluations, appraising the methods used, assessing the quality of the economic evaluations, and summarising cost-effectiveness. Nine electronic databases were searched for full-economic evaluation studies published between January 2001 and April 2017 with no language or country restrictions. 39 economic evaluation studies were reviewed and quality assessed. Almost all the studies were from Western countries and methods were found to vary by country, setting and type of intervention. The majority, particularly “behavioural and policy” preventive interventions, were cost-effective, even cost-saving. Only four interventions were not cost effective. This systematic review suggests that economic evaluation of obesity interventions is an expanding area of research. However, methodological heterogeneity makes evidence synthesis challenging. Whilst upstream interventions show promise, an expanded and consistent approach to evaluate cost-effectiveness is needed to capture health and non-health costs and consequences.

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