The effects of weight fluctuation on the components of metabolic syndrome: a 16-year prospective cohort study in South Korea

Abstract Background Weight fluctuation (WF) is highly prevalent in parallel with the high prevalence of intentional or unintentional dieting. The health risks of frequent WF for metabolic syndrome (MS) have become a public health concern, especially for health care providers who supervise dieting as an intervention to prevent obesity-related morbidity or to improve health, as well as for the general population for whom dieting is of interest. The aim of this study was to investigate the long-term effect of WF on the risk of MS in Koreans. Methods This study analyzed secondary data from the Korean Genome and Epidemiology Study, a 16-year prospective cohort study, on 8150 individuals using time-dependent Cox regression. Results WF did not increase the risk of MS in either normal-weight or obese subjects. In an analysis of the components of MS, greater WF significantly increased the risk of abdominal obesity (HR = 1.05, 95% CI = 1.02–1.07, p < 0.001) in normal-weight individuals. However, WF did not increase the risk of hyperglycemia, low high-density lipoprotein cholesterol levels, elevated blood pressure, or raised fasting glucose in normal-weight individuals, and it did not influence any of the components of MS in obese individuals. Conclusion Since WF was found to be a risk factor for abdominal obesity, which is the most reliable predictor of MS, it should be considered when addressing weight control. Further studies on cut-off points for the degree of weight loss in a certain period need to be conducted to help clinicians provide guidance on appropriate weight control.

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The Effects of Weight Fluctuation on the Components of Metabolic Syndrome: a 16-year Prospective Cohort Study in South Korea

10.21203/rs.3.rs-166848/v1 ◽

2021 ◽

Author(s):

Young Ran Chin ◽

Eun Sun So

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Prospective Cohort Study ◽

Abdominal Obesity ◽

Prospective Cohort ◽

Weight Control ◽

Normal Weight ◽

Health Concern ◽

Care Providers ◽

Weight Fluctuation

Abstract Background: Weight fluctuation (WF) is highly prevalent in parallel with the high prevalence of intentional or unintentional dieting. The health risks of frequent WF for metabolic syndrome (MS) have become a public health concern, especially for health care providers who supervise dieting as an intervention to prevent obesity-related morbidity or to improve health, as well as for the general population for whom dieting is of interest. The aim of this study was to investigate the long-term effect of WF on the risk of MS in Koreans.Methods: This study analyzed secondary data from the Korean Genome and Epidemiology Study, a 16-year prospective cohort study, on 8,150 individuals using time-dependent Cox regression.Results: WF did not increase the risk of MS in either normal-weight or obese subjects. In an analysis of the components of MS, greater WF significantly increased the risk of abdominal obesity (HR=1.05, 95% CI=1.02-1.07, p=.002) in normal-weight individuals. However, WF did not increase the risk of hyperglycemia, low high-density lipoprotein cholesterol levels, elevated blood pressure, or raised fasting glucose in normal-weight individuals, and it did not influence any of the components of MS in obese individuals.Conclusion: Since WF was found to be a risk factor for abdominal obesity, which is the most reliable predictor of MS, it should be considered when addressing weight control. Further studies on cut-off points for the degree of weight loss in a certain period need to be conducted to help clinicians provide guidance on appropriate weight control.

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Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study

Atherosclerosis ◽

10.1016/j.atherosclerosis.2006.03.012 ◽

2007 ◽

Vol 191 (1) ◽

pp. 182-190 ◽

Cited By ~ 90

Author(s):

Altan Onat ◽

Hüseyin Uyarel ◽

Gülay Hergenç ◽

Ahmet Karabulut ◽

Sinan Albayrak ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Coronary Disease ◽

Prospective Cohort Study ◽

Abdominal Obesity ◽

Prospective Cohort ◽

Definition Of

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An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study

Metabolism ◽

10.1016/j.metabol.2016.11.003 ◽

2017 ◽

Vol 67 ◽

pp. 54-61 ◽

Cited By ~ 24

Author(s):

Ji Hye Huh ◽

Dhananjay Yadav ◽

Jae Seok Kim ◽

Jung-Woo Son ◽

Eunhee Choi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Prospective Cohort Study ◽

Prospective Cohort

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Metabolic syndrome as a risk factor for total hip or knee replacement due to primary osteoarthritis: a prospective cohort study (the HUNT study and the Norwegian Arthroplasty Register)

Clinical Epidemiology ◽

10.2147/clep.s145823 ◽

2018 ◽

Vol Volume 10 ◽

pp. 83-96 ◽

Cited By ~ 10

Author(s):

Alf Inge Hellevik ◽

Marianne Bakke Johnsen ◽

Arnulf Langhammer ◽

Valborg Baste ◽

Ove Furnes ◽

...

Keyword(s):

Metabolic Syndrome ◽

Risk Factor ◽

Cohort Study ◽

Knee Replacement ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Arthroplasty Register ◽

Total Hip ◽

Hunt Study ◽

Norwegian Arthroplasty Register

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Gestational metabolic syndrome and neonatal anthropometric indices: a prospective cohort study

British Journal of Midwifery ◽

10.12968/bjom.2021.29.7.386 ◽

2021 ◽

Vol 29 (7) ◽

pp. 386-391

Author(s):

Zeinab Hatamian ◽

Lida Moghaddam-Banaem ◽

Samira Mokhlesi ◽

Marzieh Saei Ghare Naz

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Birth Weight ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Linear Regression Analysis ◽

First Trimester ◽

P Value ◽

Anthropometric Parameters ◽

First Trimester Of Pregnancy

Background and aim There is limited knowledge about the effect of maternal metabolic syndrome (MetS) on the anthropometric parameters of newborns. Therefore, the authors aimed to evaluate the association between MetS in the first trimester of pregnancy with weight and height of the newborn. Methods This prospective cohort study was conducted on 455 pregnant women in Tehran during their first trimester of pregnancy. MetS was defined as the coexistence of three or more of the following criteria: fasting blood sugar (FBS) level ≥92 mg/dl, blood pressure ≥130.85 mm/hg, triglyceride ≥150 mg/dl, high density lipoprotein ≤50 mg/dl, and body mass index (BMI) ≥30 kg/m2. All participants were followed up to childbirth. After birth, the baby's weight and height data were collected from the birth certificate. Results Linear regression analysis showed FBS (ß: 0.100, p-value: 0.038), BMI (ß: 0.139, p-value: 0.004), and MetS (ß: -0.122, p-value: 0.015) were significantly associated with birth weight but no statistically significant results were found for birth height. Conclusion MetS and some of its components in pregnancy can affect birth weight of neonates.

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Delayed Lactogenesis Is Associated with Suboptimal Breastfeeding Practices: A Prospective Cohort Study

Journal of Nutrition ◽

10.1093/jn/nxz311 ◽

2019 ◽

Vol 150 (4) ◽

pp. 894-900 ◽

Cited By ~ 1

Author(s):

Li Huang ◽

Shangzhi Xu ◽

Xi Chen ◽

Qian Li ◽

Lixia Lin ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cox Regression ◽

Normal Weight ◽

Face To Face ◽

Gestational Weight ◽

Breastfeeding Practices ◽

Suboptimal Breastfeeding ◽

Adjusted Model

ABSTRACT Background Breastfeeding has many established health benefits to both babies and mothers. There is limited evidence on the association between delayed lactogenesis and breastfeeding practices. Objective We assessed the association between delayed lactogenesis and breastfeeding practices in women initiating breastfeeding. Design We used data from a prospective cohort study in Wuhan, China, which enrolled pregnant women at 8–16 weeks of gestation and followed up to postpartum. Women were included who had a singleton live birth, initiated breastfeeding, and provided information on infant feeding. Maternal lactogenesis status was assessed by face-to-face interview at day 4 postpartum. Breastfeeding practices (full breastfeeding and/or any breastfeeding) were queried by telephone interview at 3, 6, and 12 mo postpartum. Poisson regression and Cox regression were used to identify the association between delayed lactogenesis and breastfeeding practices. Results Delayed lactogenesis was reported by 17.9% of the 2877 participants. After adjusting for potential confounders, when compared with timely lactogenesis, delayed lactogenesis was significantly associated with higher risk of inability to sustain full breastfeeding at 3 mo postpartum (RR: 1.24, 95% CI: 1.10, 1.39) and 6 mo postpartum (RR: 1.14, 95% CI: 1.04, 1.24). Delayed lactogenesis was also significantly associated with early termination of any breastfeeding (HR: 1.15, 95% CI: 1.01, 1.30) in the adjusted model. In a combined analysis, women with higher gestational weight gain (GWG, ≥16 kg for underweight and normal weight, 15 kg for overweight/obesity) and who subsequently experienced delayed lactogenesis had the highest risk of ending any breastfeeding earlier (adjusted HR: 1.32, 95% CI: 1.11, 1.55) compared with those who gained less GWG and experienced timely lactogenesis. Conclusions This study shows that delayed lactogenesis was associated with low rate of full breastfeeding and shorter duration of any breastfeeding. Greater efforts to promote breastfeeding should be targeted towards women with delayed lactogenesis.

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