Evaluation of cognitive function in patients with severe anorexia nervosa before and after medical stabilization

Anorexia Nervosa (AN) is a severe and often enduring disorder characterized by restriction of food intake, low body weight, fear of weight gain, and distorted body image. Investigations on cognition performance in AN patients have yielded conflicting results. Using an established and sensitive computerized cognitive test battery, we aimed to assess core aspects of cognitive function, including attention span, information processing, reasoning, working and episodic memory, in AN patients and controls. Patients were recruited from the Danish Prospective Longitudinal all-comer inclusion study in Eating Disorders (PROLED). Included were 26 individuals with AN and 36 healthy volunteers (HV). All were tested with CogTrack (an online cognitive assessment system) at baseline, and AN patients were tested again at a follow-up time point after weight increase (n = 13). At baseline, AN patients showed faster reaction times in the attention tasks, as well as increased accuracy in grammatical reasoning compared to HV. There were no differences in cognitive function between AN patients and HV in the other cognitive domains measured (sustained attention, working and episodic memory, speed of retrieval, and speed of grammatical reasoning). No differences were visible in the AN sample between baseline and follow-up. Performance did not correlate with any clinical variables in the AN sample. These findings supplement results from other studies suggesting increased concentration and reasoning accuracy in patients suffering from AN, who showed increased performance in cognitive tasks despite their illness.

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Regular Taekwondo Training Affects Mood State and Sociality but Not Cognitive Function among International Students in South Korea

Healthcare ◽

10.3390/healthcare9070820 ◽

2021 ◽

Vol 9 (7) ◽

pp. 820

Author(s):

Ju-Yong Bae ◽

Hee-Tae Roh

Keyword(s):

International Students ◽

Cognitive Function ◽

South Korea ◽

Physical Fitness ◽

Mood State ◽

Control Group ◽

Peer Relationship ◽

Physical Fitness Test ◽

Before And After ◽

Experimental Group

We aimed to investigate the effect of Taekwondo training on physical fitness, mood, sociality, and cognitive function among international students in South Korea. We randomly assigned 24 international students to a control group (CG, n = 12) and experimental group (EG, n = 12). The EG performed Taekwondo training for 16 weeks, while the CG did not train. Each participant underwent a physical fitness test and sociability questionnaire before and after the intervention. We also examined changes in mood state and cognitive function, using the Korean version of the Profile of Mood State-Brief (K-POMS-B), and the Stroop Color and Word test, respectively. Regarding the physical fitness variables, sit-and-reach records in the EG significantly increased after intervention (p < 0.05). In the sub-variable of K-POMS-B, Vigor-Activity scores significantly increased (p < 0.05) after intervention, while the Fatigue-Inertia scores significantly decreased in the EG (p < 0.05). Furthermore, in the EG, peer relationship scores, a sub-variable of sociability, significantly decreased after intervention (p < 0.05). These findings suggest that Taekwondo training can not only improve flexibility among physical fitness factors, but can also be effective in improving the mood state and sociality of international students.

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Weight Status, Leptin, and Cognitive Function in Anorexia Nervosa

10.17918/etd-6543 ◽

2021 ◽

Author(s):

Staci A. Berkowitz

Keyword(s):

Anorexia Nervosa ◽

Cognitive Function ◽

Weight Status

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Serum Immunoreactive Leptin Concentrations in Patients with Anorexia Nervosa before and after Partial Weight Recovery

Biochemical and Molecular Medicine ◽

10.1006/bmme.1996.2564 ◽

1997 ◽

Vol 60 (2) ◽

pp. 116-120 ◽

Cited By ~ 45

Author(s):

Felipe F. Casanueva ◽

Carlos Dieguez ◽

Vera Popovic ◽

Roberto Peino ◽

Robert V. Considine ◽

...

Keyword(s):

Anorexia Nervosa ◽

Before And After ◽

Partial Weight

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Grooved Pegboard Test Performance Before and After Cerebral-Spinal Fluid Tap Test in Patients with Normal Pressure Hydrocephalus

10.21203/rs.3.rs-29451/v1 ◽

2020 ◽

Author(s):

Caiyan Liu ◽

Liling Dong ◽

Chenhui Mao ◽

Jie Li ◽

Xinying Huang ◽

...

Keyword(s):

Cognitive Function ◽

Upper Extremity ◽

Normal Pressure Hydrocephalus ◽

Test Performance ◽

Normal Pressure ◽

Periventricular White Matter ◽

Tap Test ◽

Functional Scores ◽

Before And After ◽

Grooved Pegboard Test

Abstract Background Motor impairment in patients with normal pressure hydrocephalus (NPH) can extend beyond gait and include deficits in upper extremity functions and psychomotor speed. Evaluation of upper extremity function will be helpful for NPH patients who are unable to ambulate (e.g., wheelchair-bound patients) and may not be able to comply with the gait evaluation. Our study aimed to explore the use of the grooved pegboard test to assess responsiveness to the cerebrospinal fluid (CSF) tap test in patients with NPH. Methods Seventy-seven possible NPH patients were enrolled from 2013 to 2018. All patients underwent detailed neuropsychological and walking assessments, CSF tap tests, and brain magnetic resonance imaging. The grooved pegboard test results before and after the CSF tap test were compared and correlated with the other clinical assessments. In diffusion tensor imaging analysis, the fractional anisotropy (FA) and mean diffusivity (MD) values of periventricular white matter were measured by the region of interest method and were correlated with pegboard test performance.Results The grooved pegboard test scores significantly improved after the CSF tap test and correlated with patient walking ability, cognitive function, and functional scores (P < 0.01). The improvement ratios in the complex visual motor speed index (i.e., the grooved pegboard test performance combined with the Symbol-Digit Modalities Test performance) were significantly different between the CSF tap test responder and nonresponder groups. The grooved pegboard test times were significantly correlated with the FA values in right periventricular lesions (P=0.017).Conclusions The performance on the grooved pegboard test was related to lower extremity motor ability and cognitive function. It can be used as an alternative evaluation tool for patients who are unable to ambulate and may not be able to comply with the gait evaluation.

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